Ligand-based pharmacophore modelling, in silico virtual screening, molecular docking and molecular dynamic simulation study to identify novel Francisella tularensis ParE inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Papers"
DOI: 10.1007/s11696-020-01274-3
Abstract: ParE, a subunit of topoisomerase IV, is involved in the management of DNA topology and validated to be an attractive target for the development of antibacterial agents. Availability of the crystal structure of Francisella tularensis… read more here.
Keywords: tularensis; pare inhibitors; pharmacophore modelling; tularensis pare ... See more keywords
Rapid viability polymerase chain reaction method for detection of Francisella tularensis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of microbiological methods"
DOI: 10.1016/j.mimet.2019.105738
Abstract: Francisella tularensis, which causes potentially fatal tularemia, has been considered an attractive agent of bioterrorism and biological warfare due to its low infectious dose, reported environmental persistence, and ability to be transmitted to humans via… read more here.
Keywords: tularensis; rapid viability; method; polymerase chain ... See more keywords
Serological evidence of Francisella tularensis in febrile patients seeking treatment at remote hospitals, northeastern Kenya, 2014–2015
Sign Up to like & getrecommendations! Published in 2017 at "New Microbes and New Infections"
DOI: 10.1016/j.nmni.2017.05.015
Abstract: Tularaemia is a highly contagious infectious zoonosis caused by the bacterial agent Francisella tularensis. The aim of this study was to investigate the presence of antibodies to F. tularensis in febrile patients in northeastern Kenya.… read more here.
Keywords: tularensis; febrile patients; kenya; northeastern kenya ... See more keywords
Rapid antigen tests for positive Covid-19 confirmation in the laboratory setting
Sign Up to like & getrecommendations! Published in 2022 at "Pathology"
DOI: 10.1016/j.pathol.2021.12.271
Abstract: S S83 The patient was treated initially with pulse methylprednisolone followed by tapered oral prednisone, and mycophenolate mofetil but transitioned rapidly with effect after 1 week to rituximab 1 g at day 0 and 14… read more here.
Keywords: rapid antigen; antigen tests; tularensis; pathology ... See more keywords
CD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10156-6
Abstract: Pulmonary immune control is crucial for protection against pathogens. Here we identify a pathway that promotes host responses during pulmonary bacterial infection; the expression of CD200 receptor (CD200R), which is known to dampen pulmonary immune… read more here.
Keywords: neutrophil niche; francisella tularensis; tularensis; cd200r ... See more keywords
Francisella tularensis novicida infection competence differs in cell lines derived from United States populations of Dermacentor andersoni and Ixodes scapularis
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30419-4
Abstract: In the United States, Dermacentor spp. are common vectors of Francisella tularensis subspecies (ssp.), while Ixodes scapularis is not, though the geographic distribution and host range of pathogen and tick overlap. To examine if differences… read more here.
Keywords: novicida infection; competence; cell lines; infection ... See more keywords
Structural and functional studies of the metalloregulator Fur identify a promoter-binding mechanism and its role in Francisella tularensis virulence
Sign Up to like & getrecommendations! Published in 2018 at "Communications Biology"
DOI: 10.1038/s42003-018-0095-6
Abstract: Francisella tularensis is a Gram-negative bacterium causing tularaemia. Classified as possible bioterrorism agent, it may be transmitted to humans via animal infection or inhalation leading to severe pneumonia. Its virulence is related to iron homeostasis… read more here.
Keywords: tularensis; mechanism; virulence; role ... See more keywords
Arginine 58 is indispensable for proper function of the Francisella tularensis subsp. holarctica FSC200 HU protein, and its substitution alters virulence and mediates immunity against wild-type strain
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2132729
Abstract: ABSTRACT HU protein, a member of the nucleoid-associated group of proteins, is an important transcription factor in bacteria, including in the dangerous human pathogen Francisella tularensis. Generally, HU protein acts as a DNA sequence non-specific… read more here.
Keywords: tularensis subsp; fsc200; tularensis; subsp holarctica ... See more keywords
Genomic characterization of Francisella tularensis and other diverse Francisella species from complex samples
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1101/2022.08.07.503100
Abstract: Francisella tularensis, the bacterium that causes the zoonosis tularemia, and its genetic near neighbor species, can be difficult or impossible to cultivate from complex samples. Thus, there is a lack of genomic information for these… read more here.
Keywords: dna; francisella; diverse; complex samples ... See more keywords
Francisella tularensis prevalence and load in Dermacentor reticulatus ticks in an endemic area in Central Europe
Sign Up to like & getrecommendations! Published in 2017 at "Medical and Veterinary Entomology"
DOI: 10.1111/mve.12229
Abstract: A total of 7778 host‐seeking adult Dermacentor reticulatus (Ixodida: Ixodidae) ticks were examined for the prevalence of Francisella tularensis holarctica (Thiotrichales: Francisellaceae) in a natural focus of tularaemia in the floodplain forest–meadow ecosystem along the… read more here.
Keywords: tularensis; prevalence; reticulatus; dermacentor reticulatus ... See more keywords
In Vitro Antibiotic Susceptibilities of Francisella tularensis Determined by Broth Microdilution following CLSI Methods
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00612-17
Abstract: ABSTRACT In vitro susceptibilities for 47 antibiotics were determined in 30 genetic diverse strains of Francisella tularensis by the broth microdilution method following Clinical and Laboratory Standards Institute (CLSI) methods. The F. tularensis strains demonstrated… read more here.
Keywords: tularensis; antibiotic susceptibilities; clsi methods; broth microdilution ... See more keywords