Aggregation‐Induced‐Emission Photosensitizer‐Loaded Nano‐Superartificial Dendritic Cells with Directly Presenting Tumor Antigens and Reversed Immunosuppression for Photodynamically Boosted Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202208555
Abstract: The success of tumor immunotherapy highlights the potential of harnessing immune system to fight cancer. Activating both native T cells and exhausted T cells is a critical step for generating effective antitumor immunity, which is… read more here.
Keywords: superartificial dendritic; induced emission; aggregation induced; tumor antigens ... See more keywords
Identification of tumor antigens and immune subtypes of glioma for mRNA vaccine development
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4633
Abstract: Recent evidence suggested that the mRNA vaccine has been effective for many tumors, but its progress in gliomas was slow. In this study, we screened potential tumor antigens and suitable populations for mRNA vaccine to… read more here.
Keywords: mrna vaccine; immune subtypes; tumor antigens; vaccine ... See more keywords
Secreted Tumor Antigens – Immune Biomarkers for Diagnosis and Therapy
Sign Up to like & getrecommendations! Published in 2017 at "PROTEOMICS"
DOI: 10.1002/pmic.201600442
Abstract: With the advent of immunotherapies for cancer, there is growing interest in the identification of tumor antigens. Tumor antigens are self‐molecules altered through e.g. genetic mutations (neoantigens), protein truncation, protein misfolding, or abnormal posttranslational modifications.… read more here.
Keywords: tumor antigens; biomarkers diagnosis; immune biomarkers; secreted tumor ... See more keywords
Identification of potential inhibitory analogs of metastasis tumor antigens (MTAs) using bioactive compounds: revealing therapeutic option to prevent malignancy.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular diversity"
DOI: 10.1007/s11030-021-10345-w
Abstract: The deeper understanding of metastasis phenomenon and detection of drug targets could be a potential approach to minimize cancer mortality. In this study, attempts were taken to unmask novel therapeutics to prevent metastasis and cancer… read more here.
Keywords: tumor antigens; metastasis; metastasis tumor; cancer ... See more keywords
Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer cell"
DOI: 10.1016/j.ccell.2020.07.013
Abstract: Cancer elimination in humans can be achieved with immunotherapy that relies on T lymphocyte-mediated recognition of tumor antigens. Several types of these antigens have been recognized based on their cellular origins and expression patterns, while… read more here.
Keywords: immunotherapy; tumor antigens; identifying targeting; human tumor ... See more keywords
TAP 1.0: A robust immunoinformatic tool for the prediction of tumor T-cell antigens based on AAindex properties
Sign Up to like & getrecommendations! Published in 2021 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2021.107452
Abstract: Immunotherapy is a research area with great potential in drug discovery for cancer treatment. Because of the capacity of tumor antigens to activate the immune response and promote the destruction of tumor cells, they are… read more here.
Keywords: tumor antigens; immunoinformatic tool; prediction; aaindex ... See more keywords
MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2022.01.10.475285
Abstract: Combining multiple therapeutic strategies in NRAS/BRAF mutant melanoma – namely MEK/BRAF kinase inhibitors, immune checkpoint inhibitors, and targeted immunotherapies – may offer an improved survival benefit by overcoming limitations associated with any individual therapy. Still,… read more here.
Keywords: presentation; mek inhibition; tumor antigens; tumor ... See more keywords
Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aak9510
Abstract: Targeting nonviral antigens in viral-driven cancer Adoptive cell transfer harnesses a patient's own T cells to destroy cancer. The strategy can successfully treat epithelial tumors driven by human papillomavirus (HPV), but it remains unclear why… read more here.
Keywords: cancer; cell; tumor antigens; immunotherapy virally ... See more keywords
Engineered skin bacteria induce antitumor T cell responses against melanoma
Sign Up to like & getrecommendations! Published in 2023 at "Science"
DOI: 10.1126/science.abp9563
Abstract: Certain bacterial colonists induce a highly specific T cell response. A hallmark of this encounter is that adaptive immunity develops preemptively, in the absence of an infection. However, the functional properties of colonist-induced T cells… read more here.
Keywords: cell; tumor antigens; skin bacteria; engineered skin ... See more keywords
CD8+ TILs in NSCLC differentiate into TEMRA via a bifurcated trajectory: deciphering immunogenicity of tumor antigens
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-002709
Abstract: Background CD8+ tumor-infiltrating lymphocytes (TILs) comprise phenotypically and functionally heterogeneous subpopulations. Of these, effector memory CD45RA re-expressing CD8+ T cells (Temra) have been discovered and characterized as the most terminally differentiated subset. However, their exact… read more here.
Keywords: cd8; tumor antigens; immunogenicity tumor; cd8 tils ... See more keywords
Abstract 3296: Tumor antigens Fetuin-A and Secreted Protein Acidic and Rich in Cysteine (SPARC) Autoantibodies as diagnostic and prognostic biomarkers in prostate cancer
Sign Up to like & getrecommendations! Published in 2019 at "Epidemiology"
DOI: 10.1158/1538-7445.am2019-3296
Abstract: Introduction: Improvements in blood-based biomarkers for distinguishing between indolent and aggressive prostate cancer are critical in enhancing the management of the disease. To address this, we have focused on the quantification of autoantibodies (AAbs) against… read more here.
Keywords: tumor antigens; cancer; prostate cancer; sera ... See more keywords