Association of Tumor-Associated Collagen Signature With Prognosis and Adjuvant Chemotherapy Benefits in Patients With Gastric Cancer
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.36388
Abstract: Key Points Question Can the accuracy of prognosis prediction be improved using a tumor-associated collagen signature of gastric cancer (TACSGC) to detect patients who are likely to benefit from adjuvant chemotherapy for GC? Findings In… read more here.
Keywords: prognosis; adjuvant chemotherapy; collagen signature; tumor associated ... See more keywords
Human Proteome Microarray identifies autoantibodies to tumor‐associated antigens as serological biomarkers for the diagnosis of hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13371
Abstract: The identification of the high‐efficiency and non‐invasive biomarkers for hepatocellular carcinoma (HCC) detection is urgently needed. This study aims to screen out potential autoantibodies to tumor‐associated antigens (TAAbs) and to assess their diagnostic value for… read more here.
Keywords: hepatocellular carcinoma; proteome microarray; associated antigens; autoantibodies tumor ... See more keywords
Reprogramming Hypoxic Tumor-associated Macrophages by Nanoglycoclusters for Boosted Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202211332
Abstract: The tumor-associated macrophages (TAMs) in intratumoral hypoxic regions are key drivers of immune escape. Reprogramming the hypoxic TAMs to antitumor phenotype holds great therapeutic benefits but remains challenging for current drugs. Here, we report an… read more here.
Keywords: associated macrophages; tumor; reprogramming hypoxic; tumor associated ... See more keywords
Novel Photo‐STING Agonists Delivered by Erythrocyte Efferocytosis‐Mimicking Pattern to Repolarize Tumor‐Associated Macrophages for Boosting Anticancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202410937
Abstract: Immunotherapy has emerged as a highly effective therapeutic strategy for cancer treatment. Cyclic guanosine monophosphate‐adenosine monophosphate synthase (cGAS)‐stimulator of interferon gene (STING) pathway activation facilitates tumor‐associated macrophage (TAM) polarization toward M1 phenotype, and Mn2+ are… read more here.
Keywords: tumor associated; immunotherapy; efferocytosis mimicking; erythrocyte efferocytosis ... See more keywords
Remodeling Tumor-Associated Neutrophils to Enhance Dendritic Cell-Based HCC Neoantigen Nano-Vaccine Efficiency.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202105631
Abstract: Hepatocellular carcinoma (HCC) commonly emerges in an immunologically "cold" state, thereafter protects it away from cytolytic attack by tumor-infiltrating lymphocytes, resulting in poor response to immunotherapy. Herein, an acidic/photo-sensitive dendritic cell (DCs)-based neoantigen nano-vaccine has… read more here.
Keywords: tumor; hcc; nano vaccine; tumor associated ... See more keywords
Tumor-Associated Macrophage-Derived Exosomal LINC01232 Induces the Immune Escape in Glioma by Decreasing Surface MHC-I Expression.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202207067
Abstract: Tumor-associated macrophage (TAM) infiltration facilitates glioma malignancy, but the underlying mechanisms remain unclear. Herein, it is reported that TAMs secrete exosomal LINC01232 to induce tumor immune escape. Mechanistically, LINC01232 is found to directly bind E2F2… read more here.
Keywords: mhc; surface; expression; escape ... See more keywords
Supramolecular Polymer-Nanomedicine Hydrogel Loaded with Tumor Associated Macrophage-Reprogramming polyTLR7/8a Nanoregulator for Enhanced Anti-Angiogenesis Therapy of Orthotopic Hepatocellular Carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300637
Abstract: Anti-angiogenic therapies targeting inhibition of vascular endothelial growth factor (VEGF) pathway show clinical benefit in hypervascular hepatocellular carcinoma (HCC) tumors. However, HCC expresses massive pro-angiogenic factors in the tumor microenvironment (TME) in response to anti-angiogenic… read more here.
Keywords: hepatocellular carcinoma; hydrogel; anti angiogenic; therapy ... See more keywords
NAMPT‐Driven M2 Polarization of Tumor‐Associated Macrophages Leads to an Immunosuppressive Microenvironment in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202303177
Abstract: Nicotinamide phosphoribosyltransferase (NAMPT) is a metabolic enzyme with key roles in inflammation. Previous studies have examined the consequences of its upregulated expression in cancer cells themselves, but studies are limited with respect to its role… read more here.
Keywords: colorectal cancer; cancer; microenvironment; tumor associated ... See more keywords
Exploring the SAR of 1,2,3‐Triazoles as Tumor‐Associated Carbonic Anhydrases IX and XII Inhibitors for Anticancer Applications
Sign Up to like & getrecommendations! Published in 2025 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.70041
Abstract: The search for novel anticancer agents has brought carbonic anhydrase (CA) isoforms IX and XII into focus due to their critical role in tumor growth and survival, particularly under hypoxic conditions. These tumor‐associated enzymes regulate… read more here.
Keywords: sar triazoles; triazoles tumor; tumor associated; xii inhibitors ... See more keywords
Tumor‐Associated Macrophages Write the Script of Cancer Obesity Paradox
Sign Up to like & getrecommendations! Published in 2025 at "BioEssays"
DOI: 10.1002/bies.202400264
Abstract: Obesity paradoxically advances cancer progression while enhancing certain immunotherapies, like anti‐PD‐1/PD‐L1. Bader et al. discovered that obesity‐driven factors increase PD‐1 on tumor‐associated macrophages (TAMs), suppressing anti‐tumor responses. Remarkably, anti‐PD‐1 therapy reverses this metabolic dysfunction, boosting… read more here.
Keywords: cancer; obesity; tumor associated; macrophages write ... See more keywords
Tumor‐associated macrophages in liver cancer: From mechanisms to therapy
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Communications"
DOI: 10.1002/cac2.12345
Abstract: Multidimensional analyses have demonstrated the presence of a unique tumor microenvironment (TME) in liver cancer. Tumor‐associated macrophages (TAMs) are among the most abundant immune cells infiltrating the TME and are present at all stages of… read more here.
Keywords: cancer; liver cancer; macrophages liver; cancer cells ... See more keywords