Association of Tumor-Associated Collagen Signature With Prognosis and Adjuvant Chemotherapy Benefits in Patients With Gastric Cancer
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.36388
Abstract: Key Points Question Can the accuracy of prognosis prediction be improved using a tumor-associated collagen signature of gastric cancer (TACSGC) to detect patients who are likely to benefit from adjuvant chemotherapy for GC? Findings In… read more here.
Keywords: prognosis; adjuvant chemotherapy; collagen signature; tumor associated ... See more keywords
Human Proteome Microarray identifies autoantibodies to tumor‐associated antigens as serological biomarkers for the diagnosis of hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13371
Abstract: The identification of the high‐efficiency and non‐invasive biomarkers for hepatocellular carcinoma (HCC) detection is urgently needed. This study aims to screen out potential autoantibodies to tumor‐associated antigens (TAAbs) and to assess their diagnostic value for… read more here.
Keywords: hepatocellular carcinoma; proteome microarray; associated antigens; autoantibodies tumor ... See more keywords
Reprogramming Hypoxic Tumor-associated Macrophages by Nanoglycoclusters for Boosted Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202211332
Abstract: The tumor-associated macrophages (TAMs) in intratumoral hypoxic regions are key drivers of immune escape. Reprogramming the hypoxic TAMs to antitumor phenotype holds great therapeutic benefits but remains challenging for current drugs. Here, we report an… read more here.
Keywords: associated macrophages; tumor; reprogramming hypoxic; tumor associated ... See more keywords
Remodeling Tumor-Associated Neutrophils to Enhance Dendritic Cell-Based HCC Neoantigen Nano-Vaccine Efficiency.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202105631
Abstract: Hepatocellular carcinoma (HCC) commonly emerges in an immunologically "cold" state, thereafter protects it away from cytolytic attack by tumor-infiltrating lymphocytes, resulting in poor response to immunotherapy. Herein, an acidic/photo-sensitive dendritic cell (DCs)-based neoantigen nano-vaccine has… read more here.
Keywords: tumor; hcc; nano vaccine; tumor associated ... See more keywords
Tumor-Associated Macrophage-Derived Exosomal LINC01232 Induces the Immune Escape in Glioma by Decreasing Surface MHC-I Expression.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202207067
Abstract: Tumor-associated macrophage (TAM) infiltration facilitates glioma malignancy, but the underlying mechanisms remain unclear. Herein, it is reported that TAMs secrete exosomal LINC01232 to induce tumor immune escape. Mechanistically, LINC01232 is found to directly bind E2F2… read more here.
Keywords: mhc; surface; expression; escape ... See more keywords
Supramolecular Polymer-Nanomedicine Hydrogel Loaded with Tumor Associated Macrophage-Reprogramming polyTLR7/8a Nanoregulator for Enhanced Anti-Angiogenesis Therapy of Orthotopic Hepatocellular Carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300637
Abstract: Anti-angiogenic therapies targeting inhibition of vascular endothelial growth factor (VEGF) pathway show clinical benefit in hypervascular hepatocellular carcinoma (HCC) tumors. However, HCC expresses massive pro-angiogenic factors in the tumor microenvironment (TME) in response to anti-angiogenic… read more here.
Keywords: hepatocellular carcinoma; hydrogel; anti angiogenic; therapy ... See more keywords
Tumor‐associated macrophages in liver cancer: From mechanisms to therapy
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Communications"
DOI: 10.1002/cac2.12345
Abstract: Multidimensional analyses have demonstrated the presence of a unique tumor microenvironment (TME) in liver cancer. Tumor‐associated macrophages (TAMs) are among the most abundant immune cells infiltrating the TME and are present at all stages of… read more here.
Keywords: cancer; liver cancer; macrophages liver; cancer cells ... See more keywords
Inhibition of Tumor-Associated Macrophages by trabectedin improves the anti-tumor adaptive immunity in response to anti-PD-1 therapy.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of immunology"
DOI: 10.1002/eji.202149379
Abstract: A considerable proportion of cancer patients are resistant or only partially responsive to immune checkpoint blockade immunotherapy. Tumor-Associated Macrophages (TAMs) infiltrating the tumor stroma suppress the adaptive immune responses and hence promote tumor immune evasion.… read more here.
Keywords: associated macrophages; tumor associated; anti tumor; adaptive immunity ... See more keywords
Deletion of the RNA regulator HuR in tumor‐associated microglia and macrophages stimulates anti‐tumor immunity and attenuates glioma growth
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23696
Abstract: Glioblastoma is a malignant brain tumor that portends a poor prognosis. Its resilience, in part, is related to a remarkable capacity for manipulating the microenvironment to promote its growth and survival. Microglia/macrophages are prime targets,… read more here.
Keywords: tumor associated; hur; rna regulator; microglia macrophages ... See more keywords
Targeting Tumor‐Associated Antigens in Hepatocellular Carcinoma for Immunotherapy: Past Pitfalls and Future Strategies
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31502
Abstract: There are few treatment options for advanced-stage hepatocellular carcinoma (HCC). Targeting tumor-associated antigens (TAAs) for HCC immunotherapy has been tested clinically for many years with limited success. Recent advances in applying mutated tumor-specific neoantigens as… read more here.
Keywords: hepatocellular carcinoma; immunotherapy; targeting tumor; tumor associated ... See more keywords
Tumor‐associated autoantibodies as early detection markers for ovarian cancer? A prospective evaluation
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31335
Abstract: Immuno‐proteomic screening has identified several tumor‐associated autoantibodies (AAb) that may have diagnostic capacity for invasive epithelial ovarian cancer, with AAbs to P53 proteins and cancer‐testis antigens (CTAGs) as prominent examples. However, the early detection potential… read more here.
Keywords: tumor associated; early detection; ovarian cancer; cancer ... See more keywords