Practical consideration for successful sequential tumor biopsies in first-in-human trials
Sign Up to like & getrecommendations! Published in 2022 at "Investigational New Drugs"
DOI: 10.1007/s10637-022-01236-4
Abstract: In first-in-human (FIH) trials, sequential tumor biopsies, i.e., two consecutive tumor biopsies, the first performed at baseline (pretreatment) and the second during the early treatment period (on-treatment), provide proof of concept in investigational new drugs.… read more here.
Keywords: sequential tumor; tumor biopsies; treatment biopsy; tumor ... See more keywords
Abstract 2324: Characterizing the secretome of freshly dissociated gastroesophageal tumor biopsies to identify immune suppressive factors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2324
Abstract: Background: Treatment response to chemoradiotherapy and immune checkpoint blockade is limited in gastroesophageal adenocarcinoma (GEA). This is likely caused by the fact that the majority of GEAs, belonging to the chromosomally instable subgroup (70%), are… read more here.
Keywords: suppressive factors; tumor biopsies; secretome freshly; immune suppressive ... See more keywords
Gene expression analysis of tumor biopsies from a trial of durvalumab to identify subsets of NSCLC with shared immune pathways.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.3041
Abstract: 3041Background: We previously reported that NSCLC pts with high pretreatment tumoral IFNG mRNA signature (sig) expression have improved outcomes (ORR, PFS, OS) to the anti-PD-L1 therapy durvalumab ... read more here.
Keywords: expression analysis; biopsies trial; gene expression; expression ... See more keywords
Fluorescence Guidance for Brain Tumor Biopsies
Sign Up to like & getrecommendations! Published in 2018 at "Brain"
DOI: 10.1364/brain.2018.bth2c.8
Abstract: To provide guidance during stereotactic biopsy in brain tumors, fluorescence spectroscopy was used in ten patients. It was shown that the fiber optical probe could provide real-time guidance with clear fluorescence in all patients. read more here.
Keywords: guidance brain; guidance; brain tumor; tumor biopsies ... See more keywords