Expression profiles of miRNAs in giant cell tumor of bone showed miR‐187‐5p and miR‐1323 can regulate biological functions through inhibiting FRS2
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.2853
Abstract: Giant cell tumor of bone (GCTB) is considered to be a kind of borderline tumor, which has a tendency to recur and translocate. MicroRNAs are one type of small noncoding RNA, which can inhibit the… read more here.
Keywords: giant cell; cell tumor; tumor bone; tumor ... See more keywords
Sclerostin immunohistochemical staining in surgically treated giant cell tumor of bone
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.26903
Abstract: Giant cell tumor of bone (GCTB) is a destructive lesion with a high potential for recurrence. RANK‐ligand targeted therapy has provided promising, yet mixed results. Sclerostin (SOST) inhibition results in a net anabolic response and… read more here.
Keywords: cell tumor; tumor bone; giant cell;
Giant Cell Tumor of Bone: An Update
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DOI: 10.1007/s11912-021-01047-5
Abstract: To highlight the new developments in the management of advanced giant cell tumor of bone, a rare locally aggressive benign tumor, which was traditionally managed with surgery alone by either curettage and local adjuvant therapy,… read more here.
Keywords: giant cell; cell tumor; tumor bone; tumor ... See more keywords
A Long-Distance Relay-tionship between Tumor and Bone.
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2017.12.011
Abstract: Myeloid cells, including neutrophils, are important regulators of tumor growth and metastasis. In Science, Engblom et al. (2017) reveal how lung tumors remotely engage bone-resident cells through a relay mechanism that achieves a sustained supply of… read more here.
Keywords: distance relay; tionship tumor; long distance; relay tionship ... See more keywords
Histological and immunohistochemical features and genetic alterations in the malignant progression of giant cell tumor of bone: a possible association with TP53 mutation and loss of H3K27 trimethylation
Sign Up to like & getrecommendations! Published in 2021 at "Modern Pathology"
DOI: 10.1038/s41379-021-00972-x
Abstract: In rare cases, giant cell tumor of bone (GCTB) can undergo primary or secondary malignant transformation to malignant giant cell tumor of bone (MGCTB), but the details of the molecular alterations are still unclear. The… read more here.
Keywords: giant cell; cell tumor; tumor bone; cell ... See more keywords
1H NMR metabolomic signatures related to giant cell tumor of the bone
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c7ra07138h
Abstract: Giant cell tumor of the bone (GCTB) is an osteolytic neoplasm of uncertain biological behavior that affects the epiphyseal ends of long bones in young adults. This study describes for the first time the 1H… read more here.
Keywords: giant cell; cell tumor; tumor bone;
Remarkable response to anti-PD-L1 blockade in relapsed and refractory metastatic malignant giant cell tumor of bone: a case report
Sign Up to like & getrecommendations! Published in 2025 at "Immunotherapy"
DOI: 10.1080/1750743x.2025.2582518
Abstract: ABSTRACT Case A 40-year-old man presented with malignant giant cell tumor of bone of the left distal femur. Despite distal femur resection/replacement and adjuvant chemotherapy, he experienced local recurrence and lung metastases. Salvage radiation therapy… read more here.
Keywords: tumor bone; tumor; case; malignant giant ... See more keywords
Current management of giant-cell tumor of bone in the denosumab era.
Sign Up to like & getrecommendations! Published in 2022 at "Japanese journal of clinical oncology"
DOI: 10.1093/jjco/hyac018
Abstract: Giant-cell tumor of bone is a rare, locally aggressive and rarely metastasizing primary bone tumor. The mainstay of treatment remains controversial and is decided by the balance between adequate surgical margin and sufficient adjacent joint… read more here.
Keywords: tumor; cell tumor; giant cell; tumor bone ... See more keywords
Denosumab and Sunitinib in the treatment of giant-cell tumor of bone with pulmonary and bone metastases in an adolescent
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DOI: 10.1097/md.0000000000017778
Abstract: Abstract Introduction: Giant cell tumor of bone with pulmonary and bone metastases is exceedingly rare in adolescents. Furthermore, Denosumab and Sunitinib in the treatment of giant cell tumor of bone has never been reported. Patient… read more here.
Keywords: cell tumor; giant cell; tumor bone; bone ... See more keywords
Giant cell tumor of bone with H3F3B mutation: A case report
Sign Up to like & getrecommendations! Published in 2023 at "Medicine"
DOI: 10.1097/md.0000000000032995
Abstract: Rationale: Giant cell tumor of bone is a locally aggressive and rarely metastasizing neoplasm that typically affects the ends of long bones or the axial skeleton of young to middle-aged adults. As many as 69%… read more here.
Keywords: cell; tumor bone; cell tumor; giant cell ... See more keywords
Malignant Giant Cell Tumor of Bone With a KRAS G12V Mutation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pediatric hematology/oncology"
DOI: 10.1097/mph.0000000000002112
Abstract: Malignant giant cell tumor of bone (GCTB) is a rare, aggressive, sarcoma occurring in adolescent and young adults. It is characterized by the presence of multinucleated giant cells and an aggressive clinical course. Because of… read more here.
Keywords: malignant giant; giant cell; tumor bone; tumor ... See more keywords