Assessment of tumor burden and response to therapy in patients with colorectal cancer using a quantitative ctDNA test for methylated BCAT1/IKZF1.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular oncology"
DOI: 10.1002/1878-0261.13178
Abstract: Failure of colorectal cancer (CRC) treatment is due to residual disease, and its timely identification is critical for patient survival. Detecting CRC-associated mutations in patient circulating cell-free DNA is confounded by tumor mutation heterogeneity, requiring… read more here.
Keywords: tumor; tumor burden; treatment; bcat1 ikzf1 ... See more keywords
High baseline tumor burden‐associated macrophages promote an immunosuppressive microenvironment and reduce the efficacy of immune checkpoint inhibitors through the IGFBP2‐STAT3‐PD‐L1 pathway
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Communications"
DOI: 10.1002/cac2.12420
Abstract: Several clinical studies have uncovered a negative correlation between baseline tumor burden and the efficacy of immune checkpoint inhibitor (ICI) treatment. This study aimed to uncover the specific mechanisms underlying the difference in sensitivity to… read more here.
Keywords: immune checkpoint; baseline tumor; tumor burden; efficacy immune ... See more keywords
Plasma cell‐free DNA quantification is highly correlated to tumor burden in children with neuroblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1586
Abstract: To evaluate plasma cell‐free DNA (cfDNA) as a promising biomarker for neuroblastoma (NB) tumor burden. Seventy‐nine eligible patients with newly diagnosed NB were recruited from Beijing Children's Hospital between April 2016 and April 2017. Additionally,… read more here.
Keywords: cfdna; plasma; dna; tumor burden ... See more keywords
The prognostic utility of the “Tumor Burden Score” based on preoperative radiographic features of colorectal liver metastases
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.24678
Abstract: Recently, a tumor‐burden “metro ticket” score (TBS) based on final pathology was proposed to predict outcome following resection of colorectal liver metastasis (CRLM). We sought to validate the TBS prognostic tool using preoperative radiologic cross‐sectional… read more here.
Keywords: prognostic utility; score; colorectal liver; tumor burden ... See more keywords
Optimal time point of response assessment for predicting survival is associated with tumor burden in hepatocellular carcinoma receiving repeated transarterial chemoembolization
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DOI: 10.1007/s00330-022-08716-4
Abstract: Objective response rate (ORR) under mRECIST criteria after transarterial chemoembolization (TACE) is a well-perceived surrogate endpoint of overall survival (OS). However, its optimal time point remains controversial and may be influenced by tumor burden. We… read more here.
Keywords: best orr; survival; tumor burden; tumor ... See more keywords
Surgical management for peritoneal carcinomatosis of appendiceal origin with a high-tumor burden
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DOI: 10.1007/s00595-019-01856-z
Abstract: Purpose Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) is the active treatment for peritoneal carcinomatosis of appendiceal origin. However, surgical management is sometimes difficult in patients with a high-tumor burden. Methods A high-tumor burden was… read more here.
Keywords: patients pci; high tumor; peritoneal carcinomatosis; tumor burden ... See more keywords
Clinical implications of circulating cell-free DNA quantification and metabolic tumor burden in advanced non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Lung cancer"
DOI: 10.1016/j.lungcan.2019.06.014
Abstract: OBJECTIVES This study unravels the significance of cell-free DNA (cfDNA) quantification as a promising measure of the biological behavior/aggressiveness of tumors. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) measured by positron emission tomography/computed… read more here.
Keywords: cfdna; tumor burden; cell; cfdna levels ... See more keywords
p53-Bad* Fusion Gene Therapy Induces Apoptosis In Vitro and Reduces Zebrafish Tumor Burden in Hepatocellular Carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00665
Abstract: With few curative treatments and a global yearly death rate of over 800,000, hepatocellular carcinoma (HCC) desperately needs new therapies. Although wild-type p53 gene therapy has been shown to be safe in HCC patients, it… read more here.
Keywords: fusion; apoptosis; hcc; p53 bad ... See more keywords
Magnetic Resonance Imaging and Bioluminescence Imaging for Evaluating Tumor Burden in Orthotopic Colon Cancer
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DOI: 10.1038/s41598-019-42230-w
Abstract: Quantifying tumor burden is important for following the natural history of orthotopic colon cancer and therapeutic efficacy. Bioluminescence imaging (BLI) is commonly used for such assessment and has both advantages and limitations. We compared BLI… read more here.
Keywords: tumor burden; colon cancer; orthotopic colon; colon ... See more keywords
Combination of Circulating Cell-Free DNA and Positron Emission Tomography to Distinguish Non-Small Cell Lung Cancer from Tuberculosis.
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DOI: 10.1093/labmed/lmac085
Abstract: OBJECTIVE Non-small cell lung cancer (NSCLC) holds high metabolic tumor burden and circulating cell-free DNA (cfDNA) levels, and the relationship between metabolic tumor burden and cfDNA in NSCLC and the underlying mechanism of their interaction… read more here.
Keywords: tuberculosis; tumor burden; cell; metabolic tumor ... See more keywords
BOLD Asynchrony Elucidates Tumor Burden in IDH-Mutated Gliomas.
Sign Up to like & getrecommendations! Published in 2021 at "Neuro-oncology"
DOI: 10.1093/neuonc/noab154
Abstract: BACKGROUND Gliomas comprise the most common type of primary brain tumor, are highly invasive, and often fatal. IDH-mutated gliomas are particularly challenging to image and there is currently no clinically accepted method for identifying the… read more here.
Keywords: mutated gliomas; bold asynchrony; tumor burden; idh mutated ... See more keywords