An Engineered Patient‐Derived Tumor Organoid Model That Can Be Disassembled to Study Cellular Responses in a Graded 3D Microenvironment
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202105349
Abstract: Patient‐derived organoids (PDOs) are emerging as powerful models to capture the genetic heterogeneity of human tumors. However, the self‐assembling nature of PDOs limits their use in studies of the impact of microenvironmental heterogeneity on tumor… read more here.
Keywords: tumor; response; model; patient derived ... See more keywords
Instructive Hydrogels for Primary Tumor Cell Culture: Current Status and Outlook
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DOI: 10.1002/adhm.202102479
Abstract: Primary tumor organoids (PTOs) growth in hydrogels have emerged as an important in vitro model that recapitulates many characteristics of the native tumor tissue, and have important applications in fundamental cancer research and for the… read more here.
Keywords: instructive hydrogels; cell culture; primary tumor; tumor cell ... See more keywords
High‐Throughput, Living Single‐Cell, Multiple Secreted Biomarker Profiling Using Microfluidic Chip and Machine Learning for Tumor Cell Classification
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202102800
Abstract: Secreted proteins provide abundant functional information on living cells and can be used as important tumor diagnostic markers, of which profiling at the single‐cell level is helpful for accurate tumor cell classification. Currently, achieving living… read more here.
Keywords: living single; cell; cell classification; single cell ... See more keywords
Brain Tumor Cell Membrane‐Coated Lanthanide‐Doped Nanoparticles for NIR‐IIb Luminescence Imaging and Surgical Navigation of Glioma
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200521
Abstract: Intraoperative visualization of the full extent of brain tumor by luminescence imaging helps to improve the degree and accuracy of brain tumor resection, thereby prolonging the survival of patients. However, the limited imaging depth and… read more here.
Keywords: cell membrane; brain tumor; brain; tumor cell ... See more keywords
Lactate Detection in Tumor Cell Cultures Using Organic Transistor Circuits.
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DOI: 10.1002/adma.201605744
Abstract: A biosensing platform based on an organic transistor circuit for metabolite detection in highly complex biological media is introduced. The sensor circuit provides inherent background subtraction allowing for highly specific, sensitive lactate detection in tumor… read more here.
Keywords: detection; organic transistor; lactate detection; detection tumor ... See more keywords
Membrane‐Fusion‐Mediated Multiplex Engineering of Tumor Cell Surface Glycans for Enhanced NK Cell Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202206989
Abstract: Natural killer (NK) cell therapies show potential for tumor treatment but are immunologically resisted by the overexpressed immunosuppressing tumor cell surface glycans. To reverse this glycan‐mediated immunosuppression, the surface NK‐inhibitory glycan expressions need to be… read more here.
Keywords: cell; cell surface; membrane; tumor ... See more keywords
Tumor Cell Nanovaccines Based on Genetically Engineered Antibody‐Anchored Membrane
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202208923
Abstract: Despite the promise in whole‐tumor cell vaccines, a key challenge is to overcome the lack of costimulatory signals. Here, agonistic‐antibody‐boosted tumor cell nanovaccines are reported by genetically engineered antibody‐anchored membrane (AAM) technology, capable of effectively… read more here.
Keywords: cell; anchored membrane; tumor cell; tumor ... See more keywords
Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature‐on‐a‐Chip System Correlates with Tumor Heterogeneity and Subtypes
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Science"
DOI: 10.1002/advs.201801531
Abstract: Abstract The perivascular niche (PVN) plays an essential role in brain tumor stem‐like cell (BTSC) fate control, tumor invasion, and therapeutic resistance. Here, a microvasculature‐on‐a‐chip system as a PVN model is used to evaluate the… read more here.
Keywords: chip system; microvasculature chip; tumor cell; vivo dynamics ... See more keywords
Clinical significance of CD8-positive lymphocytes on tumor cell clusters of ascites cell block in ovarian high-grade serous carcinoma.
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DOI: 10.1002/cam4.4592
Abstract: BACKGROUND The clinical significance of CD8-positive (CD8+ ) lymphocytes on tumor cell clusters of ascites cell blocks in patients with ovarian high-grade serous carcinoma (HGSC) was investigated. METHODS Among HGSC patients who underwent surgery from… read more here.
Keywords: group; cd8; cd8 lymphocytes; cell ... See more keywords
Tumor cell‐intrinsic RIG‐I signaling governs synergistic effects of immunogenic cancer therapies and checkpoint inhibitors in mice
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202049158
Abstract: Novel immunotherapeutic concepts, including immune checkpoint inhibitors of PD-1 and CTLA-4, have dramatically changed clinical practice in cancer treatment. These therapies (re)invigorate T-cell-based tumor immune responses. However, for many patients these therapies fail, as the… read more here.
Keywords: checkpoint inhibitors; immune responses; tumor cell; cancer ... See more keywords
CNBP controls tumor cell biology by regulating tumor‐promoting gene expression
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23030
Abstract: Cellular nucleic acid‐binding protein (CNBP) is associated with cell proliferation, and its expression is elevated in human tumors, but the molecular mechanisms of CNBP in tumor cell biology have not been fully elucidated. In this… read more here.
Keywords: cnbp; cell biology; tumor cell; biology ... See more keywords