A numerical study on tumor-on-chip performance and its optimization for nanodrug-based combination therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Biomechanics and modeling in mechanobiology"
DOI: 10.1007/s10237-021-01426-8
Abstract: Microfluidic devices, such as the tumor-on-a-chip (ToC), allow for the delivery of multiple drugs as desired for various therapies such as cancer treatment. Due to the complexity involved, visualizing, and gaining knowledge of the performance… read more here.
Keywords: combination; tumor chip; study; chip performance ... See more keywords
Colorectal tumor-on-a-chip system: A 3D tool for precision onco-nanomedicine
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aaw1317
Abstract: This colorectal tumor-on-chip model is an original and reliable platform for high-throughput drug screening and genetic expression. Awareness that traditional two-dimensional (2D) in vitro and nonrepresentative animal models may not completely emulate the 3D hierarchical… read more here.
Keywords: colorectal tumor; tumor chip; model; precision ... See more keywords
Abstract 4614: Investigating lymphatic vessel remodeling and anti-tumor immunity in pancreatic cancer using tumor-on-chip and mouse models
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4614
Abstract: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest tumors in humans. PDAC has an immunosuppressive tumor microenvironment, constituting for poor immunotherapy outcomes. Lymphatic vessels (LVs) transport leukocytes and antigens from tumor peripheries to draining… read more here.
Keywords: anti tumor; pdac cells; tumor chip; tumor ... See more keywords
Recent advances in vascularized tumor-on-a-chip
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1150332
Abstract: The vasculature plays a critical role in cancer progression and metastasis, representing a pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on-a-chip technology has proven to be a robust… read more here.
Keywords: chip; vascularized tumor; tumor chip; advances vascularized ... See more keywords