Advancing Targeted Drug Delivery in Glioblastoma Multiforme Through Biomimetic Nanomedicine Using 3D Tumor-On-a-Chip Model.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202502454
Abstract: The prognosis of glioblastoma multiforme (GBM) remains dismal, despite standard treatment regimens. A key challenge in treating GBM is the persistence of glioma stem cells (GSCs) within the perivascular niche (PVN) - a protective tumor… read more here.
Keywords: drug delivery; drug; tumor; glioblastoma multiforme ... See more keywords
A numerical study on tumor-on-chip performance and its optimization for nanodrug-based combination therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Biomechanics and modeling in mechanobiology"
DOI: 10.1007/s10237-021-01426-8
Abstract: Microfluidic devices, such as the tumor-on-a-chip (ToC), allow for the delivery of multiple drugs as desired for various therapies such as cancer treatment. Due to the complexity involved, visualizing, and gaining knowledge of the performance… read more here.
Keywords: combination; tumor chip; study; chip performance ... See more keywords
Colorectal tumor-on-a-chip system: A 3D tool for precision onco-nanomedicine
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aaw1317
Abstract: This colorectal tumor-on-chip model is an original and reliable platform for high-throughput drug screening and genetic expression. Awareness that traditional two-dimensional (2D) in vitro and nonrepresentative animal models may not completely emulate the 3D hierarchical… read more here.
Keywords: colorectal tumor; tumor chip; model; precision ... See more keywords
Abstract 4614: Investigating lymphatic vessel remodeling and anti-tumor immunity in pancreatic cancer using tumor-on-chip and mouse models
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4614
Abstract: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest tumors in humans. PDAC has an immunosuppressive tumor microenvironment, constituting for poor immunotherapy outcomes. Lymphatic vessels (LVs) transport leukocytes and antigens from tumor peripheries to draining… read more here.
Keywords: anti tumor; pdac cells; tumor chip; tumor ... See more keywords
Abstract 6764: Vascularized tumor-on-chip model for evaluating chemotherapeutic-mediated damage to adjacent healthy tissue
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-6764
Abstract: Introduction: Systemic chemotherapy is an effective anticancer treatment for all stages of breast cancer, with intravenous (IV) infusion being the principal method of administration. In addition to targeting cancer, systemic chemotherapy can impact the viability… read more here.
Keywords: cancer; tissue; tumor; model ... See more keywords
Abstract LB447: Drug delivery and efficacy testing using vascularized tumor-on-a-chip
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-lb447
Abstract: The inhibition of tumor angiogenesis is considered a promising strategy to impede cancer progression, as the vasculature associated with tumors plays a crucial role in supplying blood and facilitating metastasis. Therefore, the in vitro replication… read more here.
Keywords: cancer; vascularized tumor; hybrid spheroids; tumor ... See more keywords
Abstract 1209: A novel vascularized tumor-on-a-chip model for tracking melanoma-dendritic cell interactions following combined romidepsin and type I IFN therapy
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-1209
Abstract: Dendritic cells (DCs) are key players in melanoma immune surveillance, presenting tumor antigens to CD8+ T cells that target tumor cells. However, the interaction between DCs and tumor cells in the melanoma microenvironment is complex,… read more here.
Keywords: novel vascularized; tumor; cell; model ... See more keywords
Hybrid-integrated devices for mimicking malignant brain tumors (“tumor-on-a-chip”) for in vitro development of targeted drug delivery and personalized therapy approaches
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2024.1452298
Abstract: Acute and requiring attention problem of oncotheranostics is a necessity for the urgent development of operative and precise diagnostics methods, followed by efficient therapy, to significantly reduce disability and mortality of citizens. A perspective way… read more here.
Keywords: brain; therapy; brain tumors; tumor chip ... See more keywords
Recent advances in vascularized tumor-on-a-chip
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1150332
Abstract: The vasculature plays a critical role in cancer progression and metastasis, representing a pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on-a-chip technology has proven to be a robust… read more here.
Keywords: chip; vascularized tumor; tumor chip; advances vascularized ... See more keywords