Tumor-Colonizing E. coli Expressing Both Collagenase and Hyaluronidase Enhances Therapeutic Efficacy of Gemcitabine in Pancreatic Cancer Models
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DOI: 10.3390/biom14111458
Abstract: Desmoplasia is a hallmark feature of pancreatic ductal adenocarcinoma (PDAC) that contributes significantly to treatment resistance. Approaches to enhance drug delivery into fibrotic PDAC tumors continue to be an important unmet need. In this study,… read more here.
Keywords: collagenase hyaluronidase; tumor colonizing; efficacy; coli expressing ... See more keywords