Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Ophthalmology"
DOI: 10.1001/jamaophthalmol.2017.4097
Abstract: Importance Retinoblastoma (Rb) is one of the first tumors to have a known genetic etiology. However, because biopsy of this tumor is contraindicated, it has not been possible to define the effects of secondary genetic… read more here.
Keywords: copy number; dna; aqueous humor; tumor derived ... See more keywords
Personalized Vaccination of Tumor-Derived Antigens and STING Agonists for Specific Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced materials"
DOI: 10.1002/adma.202420325
Abstract: Personalized vaccines have shown their promise in cancer immunotherapy, while screening of personalized antigens remains challenging. Herein, a personalized immunotherapy strategy to treat tumors by its own mechanism is reported, which is achieved through the… read more here.
Keywords: tumor derived; antigens sting; immunotherapy; cancer immunotherapy ... See more keywords
The homologous tumor‐derived‐exosomes loaded with miR‐1270 selectively enhanced the suppression effect for colorectal cancer cells
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.6936
Abstract: Colorectal cancer (CRC), known as prevalent cancer, has risen to be the leading cause of cancer‐related death. Engineered exosomes had attracted much attention since they acted as carriers to deliver small molecule drugs, therapeutic nucleic… read more here.
Keywords: colorectal cancer; cancer; homologous tumor; tumor derived ... See more keywords
The Phenotypical and Functional Effect of PGE2 on Human Macrophages
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Immunology"
DOI: 10.1002/eji.70090
Abstract: Prostaglandin E2 (PGE2) is one important immunosuppressive factor within the tumor microenvironment (TME). Signaling through E‐prostanoid receptor type 2 (EP2) and EP4, PGE2 promotes suppressive immune cell phenotypes and impairs antitumor immunity. Blocking PGE2 signaling… read more here.
Keywords: pge2 human; tumor derived; pge2; tumor ... See more keywords
Tumor‐derived extracellular vesicles confer 5‐fluorouracil resistance in esophageal cancer via long noncoding RNA AC116025.2 delivery
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23469
Abstract: 5‐Fluorouracil (5‐FU) resistance is one of the main causes for treatment failure in esophageal cancer (EC). Here, we intended to elucidate the mechanism of tumor‐derived extracellular vesicles (TEVs)‐encapsulated long noncoding RNAs (lncRNAs) AC116025.2 in 5‐FU… read more here.
Keywords: esophageal cancer; fluorouracil resistance; resistance; ac116025 ... See more keywords
Tumor-derived high-mobility group box 1 and thymic stromal lymphopoietin are involved in modulating dendritic cells to activate T regulatory cells in a mouse model
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-017-2087-7
Abstract: High-mobility group box 1 (HMGB1) is involved in the tumor-associated activation of regulatory T cells (Treg), but the mechanisms remain unknown. In a mouse tumor model, silencing HMGB1 in tumor cells or inhibiting tumor-derived HMGB1… read more here.
Keywords: derived hmgb1; high mobility; tumor derived; tslp ... See more keywords
Tumor-derived extracellular vesicles: insights into bystander effects of exosomes after irradiation
Sign Up to like & getrecommendations! Published in 2019 at "Lasers in Medical Science"
DOI: 10.1007/s10103-019-02880-8
Abstract: This review article aims to address the kinetic of TDEs in cancer cells pre- and post-radiotherapy. Radiotherapy is traditionally used for the treatment of multiple cancer types; however, there is growing evidence to show that… read more here.
Keywords: extracellular vesicles; tumor; radiotherapy; tumor derived ... See more keywords
Co-delivery of tumor-derived exosomes with alpha-galactosylceramide on dendritic cell-based immunotherapy for glioblastoma.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.09.022
Abstract: Dendritic cell (DC) vaccine-based immunotherapy for glioblastoma multiforme (GBM) has shown apparent benefit in animal experiments and early-phase clinical trials, but the survival benefit is variable. In this work, we analyzed the mechanism of the… read more here.
Keywords: glioblastoma; tumor derived; derived exosomes; dendritic cell ... See more keywords
An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.12.001
Abstract: Tumor-derived extracellular vesicles (TEV) "educate" healthy cells to promote metastases. We found that melanoma TEV downregulated type I interferon (IFN) receptor and expression of IFN-inducible cholesterol 25-hydroxylase (CH25H). CH25H produces 25-hydroxycholesterol, which inhibited TEV uptake.… read more here.
Keywords: extracellular vesicles; defense; ch25h; tumor derived ... See more keywords
Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.103
Abstract: Group 2 innate lymphoid cells (ILC2s) are abundant in non-lymphoid tissues and increase following infectious and inflammatory insults. In solid tumors, however, ILC2s constitute a relatively small proportion of immune cells. Here, we show, using… read more here.
Keywords: lactic acid; tumor derived; ilc2s; derived lactic ... See more keywords
α-Cyperone Inhibitory Effects on Tumor-Derived DNA Trigger Microglia by STING Pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113246
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Cyperus rotundus L. (Cyperaceae) is a widespread herbal in China and widely used in Traditional Chinese Medicine for multiple effects such as anti-arthritic, anti-genotoxic, anti-mutagenic, anti-bacterial effects, and analgesic. α-Cyperone is an active… read more here.
Keywords: inhibitory effects; tumor derived; effects tumor; trigger microglia ... See more keywords