FBXW7 deletion contributes to lung tumor development and confers resistance to gefitinib therapy
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12200
Abstract: Gefitinib, an epidermal growth factor receptor–tyrosine kinase inhibitor (EGFR‐TKI), is an effective treatment for non‐small‐cell lung cancer (NSCLC) with EGFR activating mutations, but inevitably, the clinical efficacy is impeded by the emergence of acquired resistance.… read more here.
Keywords: tumor development; gefitinib; lung tumor; therapy ... See more keywords
Impact of noncoding RNAs on cancer directed immune therapies: Now then and forever
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34060
Abstract: Accumulating evidence demonstrates that the host genome's epigenetic modifications are essential for living organisms to adapt to extreme conditions. DNA methylation, covalent modifications of histone and interassociation of noncoding RNAs facilitate the cellular manifestation of… read more here.
Keywords: rnas cancer; tumor development; noncoding rnas; cancer directed ... See more keywords
Symmetries and solutions for a Fisher equation with a proliferation term involving tumor development
Sign Up to like & getrecommendations! Published in 2019 at "Mathematical Methods in the Applied Sciences"
DOI: 10.1002/mma.6105
Abstract: We consider a generalized Fisher equation involving tumor development from the point of view of the theory of symmetry reductions in partial differential equations. The study of this equation is relevant as it includes generalizations… read more here.
Keywords: tumor; tumor development; equation; fisher equation ... See more keywords
Daikenchuto (TU‐100) Suppresses Tumor Development in the Azoxymethane and APCmin/+ Mouse Models of Experimental Colon Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Phytotherapy Research"
DOI: 10.1002/ptr.5735
Abstract: Chemopreventative properties of traditional medicines and underlying mechanisms of action are incompletely investigated. This study demonstrates that dietary daikenchuto (TU‐100), comprised of ginger, ginseng, and Japanese pepper effectively suppresses intestinal tumor development and progression in… read more here.
Keywords: mouse models; apcmin mouse; tumor development; daikenchuto 100 ... See more keywords
Inhibition of TLR7 and TLR9 Reduces Human Cholangiocarcinoma Cell Proliferation and Tumor Development
Sign Up to like & getrecommendations! Published in 2021 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-021-06973-9
Abstract: Toll-like receptors (TLRs) are key players in innate immunity and modulation of TLR signaling has been demonstrated to profoundly affect proliferation and growth in different types of cancer. However, the role of TLRs in human… read more here.
Keywords: tumor development; tlr9; proliferation; tlr7 tlr9 ... See more keywords
ZFR promotes cell proliferation and tumor development in colorectal and liver cancers.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.103
Abstract: Colorectal cancer (CRC) and liver cancer are the second and fourth leading causes of cancer-related deaths in the whole world, respectively, and each year over 1.6 million people die from these diseases. To identify driver… read more here.
Keywords: cancer; zfr; tumor development; liver ... See more keywords
Interleukin 22 Signaling Regulates Acinar Cell Plasticity to Promote Pancreatic Tumor Development in Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Gastroenterology"
DOI: 10.1053/j.gastro.2019.12.010
Abstract: BACKGROUND & AIMS Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy that invades surrounding structures and metastasizes rapidly. Although inflammation is associated with tumor formation and progression, little is known about the mechanisms of this… read more here.
Keywords: tumor development; increased expression; mice; il22 ... See more keywords
Aspirin Reduces Colorectal Tumor Development in Mice and Gut Microbes Reduce its Bioavailability and Chemopreventive Effects.
Sign Up to like & getrecommendations! Published in 2020 at "Gastroenterology"
DOI: 10.1053/j.gastro.2020.05.004
Abstract: BACKGROUND & AIMS Alterations in the intestinal microbiota affect development of colorectal cancer (CRC) and drug metabolism. We studied whether the intestinal microbiota affects the ability of aspirin to reduce colon tumor development in mice.… read more here.
Keywords: tumor development; germ free; mice; mice given ... See more keywords
Immune suppressive function of IL-1α release in the tumor microenvironment regulated by calpain 1
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2088467
Abstract: ABSTRACT Interleukin-1α (IL-1α) plays an important role in inflammation and hematopoiesis. Many tumors have increased IL-1α expression. However, the immune regulatory role of secreted IL-1α in tumor development and whether it can be targeted for… read more here.
Keywords: tumor development; tumoral released; tumor microenvironment; tumor ... See more keywords
Effect of single‐nucleotide polymorphism in TERT promoter on follicular thyroid tumor development
Sign Up to like & getrecommendations! Published in 2020 at "Pathology International"
DOI: 10.1111/pin.12893
Abstract: Follicular thyroid neoplasm is a common tumor, and consists of follicular thyroid adenoma (FTA) and carcinoma (FTC). The mechanisms of tumor development of FTA and FTC are not well‐understood. Single‐nucleotide polymorphisms (SNPs) and point mutations… read more here.
Keywords: tumor development; follicular thyroid; tert promoter; tumor ... See more keywords
Tumor Microenvironment: Lactic Acid Promotes Tumor Development
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/3119375
Abstract: Lactic acid is a “metabolic waste” product of glycolysis that is produced in the body. However, the role of lactic acid in the development of human malignancies has gained increasing interest lately as a multifunctional… read more here.
Keywords: lactic acid; acid; tumor development; tumor microenvironment ... See more keywords