Evaluation of Comparative Surveillance Strategies of Circulating Tumor DNA, Imaging, and Carcinoembryonic Antigen Levels in Patients With Resected Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.1093
Abstract: Key Points Question Is serial analysis of circulating tumor DNA (ctDNA) associated with improved sensitivity and earlier detection of recurrence compared with standard imaging and evaluation of carcinoembryonic antigen (CEA) levels per National Comprehensive Cancer… read more here.
Keywords: circulating tumor; resected colorectal; colorectal cancer; tumor dna ... See more keywords
High‐throughput isolation of circulating tumor DNA: a comparison of automated platforms
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12415
Abstract: The emerging interest in circulating tumor DNA (ctDNA) analyses for clinical trials has necessitated the development of a high‐throughput method for fast, reproducible, and efficient isolation of ctDNA. Currently, the majority of ctDNA studies use… read more here.
Keywords: dna; circulating tumor; isolation; tumor dna ... See more keywords
Clinical factors associated with circulating tumor DNA (ctDNA) in primary breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12456
Abstract: Noninvasive circulating tumor DNA (ctDNA) can be used to predict breast cancer recurrence and prognosis. In this study, we detected 226 and 114 somatic variants in tumor DNA from 70 primary breast cancer (PBC) patients… read more here.
Keywords: dna ctdna; breast cancer; tumor dna; tumor ... See more keywords
Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non‐Small Cell Lung Cancer
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DOI: 10.1002/advs.201903410
Abstract: Abstract The evolutionary dynamics of tumor‐associated neoantigens carry information about drug sensitivity and resistance to the immune checkpoint blockade (ICB). However, the spectrum of somatic mutations is highly heterogeneous among patients, making it difficult to… read more here.
Keywords: checkpoint blockade; small cell; circulating tumor; non small ... See more keywords
Relationship between perioperative oncological evaluation and recurrence using circulating tumor DNA with KRAS mutation in patients with colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4677
Abstract: The detection of circulating tumor DNA (ctDNA) in colorectal cancer (CRC) by liquid biopsy may have prognostic information. In this perioperative study, we evaluate if there is a relationship between mutant allele frequency (MAF) of… read more here.
Keywords: circulating tumor; recurrence; colorectal cancer; tumor dna ... See more keywords
Association between circulating tumor DNA burden and disease burden in patients with ALK‐positive lung cancer
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DOI: 10.1002/cncr.33118
Abstract: Plasma genotyping is an emerging approach for the identification of genetic alterations mediating resistance to anaplastic lymphoma kinase (ALK)–targeted therapy. The authors reviewed plasma genotyping and imaging findings to assess the correlation between circulating tumor… read more here.
Keywords: burden disease; disease burden; circulating tumor; burden ... See more keywords
Reporting on circulating tumor DNA monitoring in metastatic cancer—From clinical validity to clinical utility
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DOI: 10.1002/cncr.34168
Abstract: This commentary attempts to discuss the required standardization of circulating tumor DNA (ctDNA) analyses and thereby improve the clinical validity of ctDNA monitoring in the metastatic setting of solid tumors. read more here.
Keywords: circulating tumor; monitoring metastatic; clinical validity; tumor dna ... See more keywords
ANALYSIS OF CIRCULATING TUMOR DNA (ctDNA) IN CEREBROSPINAL FLUID DETECTS THE PRESENCE OF CENTRAL NERVOUS SYSTEM (CNS) INVOLVEMENT IN B‐CELL LYMPHOMAS
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.3_2630
Abstract: (50%) of available biopsy and ctDNA samples respectively. Concordance between genetic profiles of biopsy and ctDNA was accurate for 22/30 patients (73.3%). Mutations of NFKBIE, TNFAIP3, STAT6, PTPN1, B2M, XPO1, ITPKB, GNA13 and SOCS1were found… read more here.
Keywords: ctdna; presence; analysis circulating; circulating tumor ... See more keywords
Patient monitoring through liquid biopsies using circulating tumor DNA
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30759
Abstract: Tumors release components such as circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and tumor‐derived extracellular vesicles into the circulation. Multiple studies have demonstrated that molecular information about tumors and metastases can be extracted from… read more here.
Keywords: circulating tumor; liquid biopsies; tumor dna; tumor ... See more keywords
Circulating tumor DNA profiling reveals clonal evolution and real‐time disease progression in advanced hepatocellular carcinoma
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DOI: 10.1002/ijc.30798
Abstract: Circulating tumor DNA (ctDNA) provides a potential non‐invasive biomarker for cancer diagnosis and prognosis, but whether it could reflect tumor heterogeneity and monitor therapeutic responses in hepatocellular carcinoma (HCC) is unclear. Focusing on 574 cancer… read more here.
Keywords: hepatocellular carcinoma; hcc; real time; circulating tumor ... See more keywords
Circulating tumor DNA analysis enables molecular characterization of pediatric renal tumors at diagnosis
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.31620
Abstract: Circulating tumor DNA (ctDNA) is a powerful tool for the molecular characterization of cancer. The most frequent pediatric kidney tumors (KT) are Wilms’ tumors (WT), but other diagnoses may occur. According to the SIOP strategy,… read more here.
Keywords: diagnosis; dna; circulating tumor; tumor dna ... See more keywords