T-cell recognition of non-mutated tumor antigens in healthy individuals: connecting endogenous immunity and tumor dormancy
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02335-7
Abstract: The concept of a dual functional programme of the immune system to destroy malignant cells but also to edit their immunogenic profile, considerably improved our understanding of the process of tumor evolution in the context… read more here.
Keywords: phase; immunity; tumor dormancy; cell ... See more keywords
Tumor Dormancy and Relapse: From a Natural Byproduct of Evolution to a Disease State.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-0068
Abstract: Species evolve by mutations and epigenetic changes acting on individuals in a population; tumors evolve by similar mechanisms at a cellular level in a tissue. This article reviews growing evidence about tumor dormancy and suggests… read more here.
Keywords: cancer; natural byproduct; tumor dormancy; dormancy ... See more keywords
Loss of MED12 Induces Tumor Dormancy in Human Epithelial Ovarian Cancer via Downregulation of EGFR.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-0134
Abstract: A high rate of disease relapse makes epithelial ovarian cancer (EOC) the leading cause of death among all gynecologic malignancies. These relapses are often due to tumor dormancy. Here we identify the RNA polymerase II… read more here.
Keywords: epithelial ovarian; dormancy; tumor dormancy; ovarian cancer ... See more keywords
Abstract 1433: Roles of noncoding RNAs in tumor dormancy of breast cancer recurrence
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-1433
Abstract: The vast majority of nuclear long non-coding RNAs (lncRNAs) are expressed in a cell type- or disease-specific manner. They often function as epigenetic factors, and are involved in higher-order chromatin structure [1-3]. Dysregulation of lncRNAs… read more here.
Keywords: cancer; breast cancer; chromatin; recurrence ... See more keywords
Bioengineered models to study tumor dormancy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biological Engineering"
DOI: 10.1186/s13036-018-0137-0
Abstract: The onset of cancer metastasis is the defining event in cancer progression when the disease is considered lethal. The ability of metastatic cancer cells to stay dormant for extended time periods and reawaken at later… read more here.
Keywords: dormancy; bioengineered models; tumor dormancy; cancer ... See more keywords
Tumor dormancy and relapse: understanding the molecular mechanisms of cancer recurrence
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DOI: 10.1186/s40779-025-00595-2
Abstract: Cancer recurrence, driven by the phenomenon of tumor dormancy, presents a formidable challenge in oncology. Dormant cancer cells have the ability to evade detection and treatment, leading to relapse. This review emphasizes the urgent need… read more here.
Keywords: cancer recurrence; dormancy; cancer; tumor dormancy ... See more keywords
Sleepyhead, deadly awakening: the dynamics of metastatic organotropism, tumor dormancy and therapeutic implications
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2025.1701031
Abstract: As per the global mortality-related data, metastasis and tumor-related relapse are the major determinants of cancer-related deaths. This phenomenon is largely driven by tumor dormancy - a state in which disseminated tumor cells (DTCs) persist… read more here.
Keywords: deadly awakening; sleepyhead deadly; tumor; dormant cells ... See more keywords
Remodeling the ECM: Implications for Metastasis and Tumor Dormancy
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13194916
Abstract: Simple Summary In this perspective article we discuss the importance of investigating the role of the ECM on tumor metastasis and tumor dormancy. First, we discuss the importance of the ECM in cancer progression. Then,… read more here.
Keywords: dormancy; tumor dormancy; metastasis; role ... See more keywords