Potential Anti-Tumor Drug: Co-Crystal 5-Fluorouracil-nicotinamide
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.9b03574
Abstract: 5-Fluorouracil-nicotinamide (5-FU-NCM), a co-crystal with a 2D layer structure formed by hydrogen bonds, was synthesized by solvent evaporation and liquid phase-assisted grinding at room temperature. Compared to 5-FU alone, the results of solubility, oil–water partition… read more here.
Keywords: potential anti; tumor drug; anti tumor; fluorouracil nicotinamide ... See more keywords
Advanced Nano-Carriers for Anti-Tumor Drug Loading
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.758143
Abstract: Chemotherapy is one of the important means of tumor therapy. However, most of the anti-tumor drugs that currently used in clinic are hydrophobic non-specific drugs, which seriously affect the efficacy of drugs. With the development… read more here.
Keywords: advanced nano; tumor drugs; drug; tumor drug ... See more keywords
Ferroptosis and Tumor Drug Resistance: Current Status and Major Challenges
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.879317
Abstract: Ferroptosis is a novel type of regulated cell death, whose unique metabolic characteristics are commonly used to evaluate the conditions of various diseases especially in tumors. Accumulating evidence supports that ferroptosis can regulate tumor development,… read more here.
Keywords: tumor drug; ferroptosis; resistance; drug resistance ... See more keywords
Kinase Inhibitor Treatment of Patients with Advanced Cancer Results in High Tumor Drug Concentrations and in Specific Alterations of the Tumor Phosphoproteome
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12020330
Abstract: Identification of predictive biomarkers for targeted therapies requires information on drug exposure at the target site as well as its effect on the signaling context of a tumor. To obtain more insight in the clinical… read more here.
Keywords: specific alterations; drug; tumor drug; patients advanced ... See more keywords
High-Dose Intermittent Treatment with the Multikinase Inhibitor Sunitinib Leads to High Intra-Tumor Drug Exposure in Patients with Advanced Solid Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14246061
Abstract: Simple Summary Multitargeted tyrosine kinase inhibitors (TKIs) provide clinical benefit in patients with cancer when daily dosed to continuously inhibit their designated targets. Alternative dosing strategies pursuing higher tumor drug concentrations may improve their benefit… read more here.
Keywords: tumor drug; high dose; treatment; tumor ... See more keywords
Syntheses of Polypeptides and Their Biomedical Application for Anti-Tumor Drug Delivery
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23095042
Abstract: Polypeptides have attracted considerable attention in recent decades due to their inherent biodegradability and biocompatibility. This mini-review focuses on various ways to synthesize polypeptides, as well as on their biomedical applications as anti-tumor drug carriers… read more here.
Keywords: anti tumor; amino acid; drug delivery; tumor drug ... See more keywords
Natural Products in Preventing Tumor Drug Resistance and Related Signaling Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27113513
Abstract: Drug resistance is still an obstacle in cancer therapy, leading to the failure of tumor treatment. The emergence of tumor drug resistance has always been a main concern of oncologists. Therefore, overcoming tumor drug resistance… read more here.
Keywords: natural products; tumor drug; signaling pathways; drug ... See more keywords
LnNP@ZIF8 Smart System for In Situ NIR-II Ratiometric Imaging-Based Tumor Drug Resistance Evaluation
Sign Up to like & getrecommendations! Published in 2022 at "Nanomaterials"
DOI: 10.3390/nano12244478
Abstract: Just-in-time evaluation of drug resistance in situ will greatly facilitate the achievement of precision cancer therapy. The rapid elevation of reactive oxygen species (ROS) is the key to chemotherapy. Hence, suppressed ROS production is an… read more here.
Keywords: evaluation; ratiometric imaging; resistance; tumor drug ... See more keywords
Hinokitiol impedes tumor drug resistance by suppressing protein kinase B/mammalian targets of rapamycin axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer"
DOI: 10.7150/jca.69449
Abstract: Chemotherapy is a treatment method commonly used for cancer and that patients showing low to no response to the treatment often developed drug resistance via multiple mechanisms. Natural products have been shown to reduce tumor… read more here.
Keywords: kinase; resistance; drug resistance; tumor drug ... See more keywords