Anti-PD1 antibody enhances the anti-tumor efficacy of MUC1-MBP fusion protein vaccine via increasing Th1, Tc1 activity and decreasing the proportion of MDSC in the B16-MUC1 melanoma mouse model.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108173
Abstract: In previous studies, we have obtained a notable anti-tumor efficacy of the recombinant MUC1-MBP vaccine in the process of mouse B16-MUC1 melanoma treatment. However, the tumor cannot be eliminated completely. We found that the tumor… read more here.
Keywords: muc1; tumor efficacy; anti tumor; muc1 mbp ... See more keywords
PD-L1 blockade enhances anti-tumor efficacy of NK cells
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DOI: 10.1080/2162402x.2018.1509819
Abstract: ABSTRACT Anti-PD-1/anti-PD-L1 therapies have shown success in cancer treatment but responses are limited to ~ 15% of patients with lymphocyte infiltrated, PD-L1 positive tumors. Hence, strategies that increase PD-L1 expression and tumor infiltration should make… read more here.
Keywords: tumor efficacy; anti tumor; expression; cell ... See more keywords
Intratumoral neoadjuvant immunotherapy based on the BO-112 viral RNA mimetic
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DOI: 10.1080/2162402x.2023.2197370
Abstract: ABSTRACT BO-112 is a poly I:C-based viral mimetic that exerts anti-tumor efficacy when intratumorally delivered in mouse models. Intratumoral BO-112 synergizes in mice with systemic anti-PD-1 mAbs and this combination has attained efficacy in PD1-refractory… read more here.
Keywords: intratumoral neoadjuvant; anti tumor; neoadjuvant immunotherapy; tumor efficacy ... See more keywords
Abstract 5148: Liposomal gemcitabine, FF-10832, improves gemcitabine (GEM) pharmacokinetics (PK) and increases anti-tumor efficacy
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DOI: 10.1158/1538-7445.am2017-5148
Abstract: Introduction: FF-10832 is a liposome suspension optimized by Fujifilm nanotechnology containing 0.5 mg/mL GEM, cholesterol, HSPC, N-MPEG-DSPE. FF-10832 is expected to improve GEM PK and have strong anti-tumor effects. The PK and anti-tumor effects of… read more here.
Keywords: gem; tumor efficacy; anti tumor; cancer ... See more keywords
Abstract 4957: The targeting drug conjugate Tye1001 displayed its potent anti-tumor efficacy in lymphoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4957
Abstract: Multiple drug-targeting strategies have been applied to drug development in order to reduce the toxic side effects of the traditional chemotherapy while enhancing its anti-tumor efficacy. Various peptides, proteins and antibodies are usually used to… read more here.
Keywords: tumor efficacy; drug; potent anti; anti tumor ... See more keywords
Abstract 5056: ABN401 demonstrates robust anti-tumor efficacy in orthotopic PDX models of MET-driven NSCLC brain metastases in a pre-clinical study
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5056
Abstract: Background Brain metastases (BM) are manifested in approximately 30-50% of patients with non-small cell lung cancer (NSCLC) and are associated with catastrophic implications on prognosis and survival. The development of blood-brain barrier-penetrant therapies for brain… read more here.
Keywords: brain metastases; anti tumor; brain; tumor efficacy ... See more keywords
Abstract 689: The codon-modified influenza virus CodaLytic™rescues immunostimulatory activity and anti-tumor efficacy in PD-1-refractory tumor models
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-689
Abstract: Multiple oncolytic viruses have been shown to induce various beneficial changes in the tumor microenvironment (TME), which ultimately support induction of anti-tumor immune responses. We have previously demonstrated that CodaLytic, a codon-modified influenza virus, can… read more here.
Keywords: codon modified; anti tumor; modified influenza; tumor efficacy ... See more keywords
Abstract 2096: A novel, orally available ferroptosis inducer targeting Fe-S assembly with significant in vivo anti-tumor efficacy
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DOI: 10.1158/1538-7445.am2024-2096
Abstract: Background: Ferroptosis is a novel form of cell death driven by iron-dependent lipid peroxidation, which disrupts cellular membranes resulting in immune-activating death. A variety of tumor types, particularly those associated with enhanced lipid and/or iron… read more here.
Keywords: cancer; ferroptosis; tumor; tumor efficacy ... See more keywords
Abstract 2475: MB5029: A novel anti-PD-1 x IL-2v with improved safety profile and enhanced anti-tumor efficacy by selectively targeting activated T cells
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-2475
Abstract: Interleukin-2 (IL-2) offers therapeutic potential for cancer treatment, however, its clinical application is limited due to systemic adverse effects, such as vascular leakage syndrome (VLS). Notably, the high affinity of IL-2 for the IL-2 receptor… read more here.
Keywords: mb5029; tumor; tumor efficacy; anti tumor ... See more keywords
Abstract 3327: L-pampo™, a TLR2/3 agonist, enhances anti-tumor immune responses and synergistically improves the anti-tumor efficacy of immune checkpoint inhibitors in cold tumors
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DOI: 10.1158/1538-7445.am2024-3327
Abstract: Introduction: Immunotherapy is a promising therapeutic approach for a wide range of cancers. However, some tumors called "cold tumors" lack infiltrating T-cells and are not responsive to immune checkpoint inhibitors (ICIs), leading to worse clinical… read more here.
Keywords: cold tumors; pampo; tumor; tumor efficacy ... See more keywords
Abstract 6757: The anti-tumor efficacy of Th1-specific TROP2 vaccine (AST-07X) in a triple-negative breast cancer murine model
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-6757
Abstract: Background: The trophoblast cell-surface antigen 2 (TROP2) is associated with enhanced tumor proliferation and poor prognosis in breast cancer. TROP2 overexpresses on various epithelial cancer cell surfaces, and is commonly found in prostate, colon, pancreas,… read more here.
Keywords: cancer; trop2; tumor; tumor efficacy ... See more keywords