Anti-PD1 antibody enhances the anti-tumor efficacy of MUC1-MBP fusion protein vaccine via increasing Th1, Tc1 activity and decreasing the proportion of MDSC in the B16-MUC1 melanoma mouse model.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108173
Abstract: In previous studies, we have obtained a notable anti-tumor efficacy of the recombinant MUC1-MBP vaccine in the process of mouse B16-MUC1 melanoma treatment. However, the tumor cannot be eliminated completely. We found that the tumor… read more here.
Keywords: muc1; tumor efficacy; anti tumor; muc1 mbp ... See more keywords
PD-L1 blockade enhances anti-tumor efficacy of NK cells
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DOI: 10.1080/2162402x.2018.1509819
Abstract: ABSTRACT Anti-PD-1/anti-PD-L1 therapies have shown success in cancer treatment but responses are limited to ~ 15% of patients with lymphocyte infiltrated, PD-L1 positive tumors. Hence, strategies that increase PD-L1 expression and tumor infiltration should make… read more here.
Keywords: tumor efficacy; anti tumor; expression; cell ... See more keywords
Intratumoral neoadjuvant immunotherapy based on the BO-112 viral RNA mimetic
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DOI: 10.1080/2162402x.2023.2197370
Abstract: ABSTRACT BO-112 is a poly I:C-based viral mimetic that exerts anti-tumor efficacy when intratumorally delivered in mouse models. Intratumoral BO-112 synergizes in mice with systemic anti-PD-1 mAbs and this combination has attained efficacy in PD1-refractory… read more here.
Keywords: intratumoral neoadjuvant; anti tumor; neoadjuvant immunotherapy; tumor efficacy ... See more keywords
Abstract 5148: Liposomal gemcitabine, FF-10832, improves gemcitabine (GEM) pharmacokinetics (PK) and increases anti-tumor efficacy
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DOI: 10.1158/1538-7445.am2017-5148
Abstract: Introduction: FF-10832 is a liposome suspension optimized by Fujifilm nanotechnology containing 0.5 mg/mL GEM, cholesterol, HSPC, N-MPEG-DSPE. FF-10832 is expected to improve GEM PK and have strong anti-tumor effects. The PK and anti-tumor effects of… read more here.
Keywords: gem; tumor efficacy; anti tumor; cancer ... See more keywords
Abstract 4957: The targeting drug conjugate Tye1001 displayed its potent anti-tumor efficacy in lymphoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4957
Abstract: Multiple drug-targeting strategies have been applied to drug development in order to reduce the toxic side effects of the traditional chemotherapy while enhancing its anti-tumor efficacy. Various peptides, proteins and antibodies are usually used to… read more here.
Keywords: tumor efficacy; drug; potent anti; anti tumor ... See more keywords
Abstract 5056: ABN401 demonstrates robust anti-tumor efficacy in orthotopic PDX models of MET-driven NSCLC brain metastases in a pre-clinical study
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5056
Abstract: Background Brain metastases (BM) are manifested in approximately 30-50% of patients with non-small cell lung cancer (NSCLC) and are associated with catastrophic implications on prognosis and survival. The development of blood-brain barrier-penetrant therapies for brain… read more here.
Keywords: brain metastases; anti tumor; brain; tumor efficacy ... See more keywords
Abstract 689: The codon-modified influenza virus CodaLytic™rescues immunostimulatory activity and anti-tumor efficacy in PD-1-refractory tumor models
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-689
Abstract: Multiple oncolytic viruses have been shown to induce various beneficial changes in the tumor microenvironment (TME), which ultimately support induction of anti-tumor immune responses. We have previously demonstrated that CodaLytic, a codon-modified influenza virus, can… read more here.
Keywords: codon modified; anti tumor; modified influenza; tumor efficacy ... See more keywords
Abstract 2269: ATR inhibitor M6620 enhances anti-tumor efficacy of the combination of the anti-PD-L1 antibody avelumab with platinum-based chemotherapy
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DOI: 10.1158/1538-7445.sabcs18-2269
Abstract: Recently, combination of checkpoint inhibitors with chemotherapy demonstrated significant improvement of overall survival (OS) and progression-free survival (PFS) compared with chemotherapy alone in patients with metastatic non-squamous and squamous non-small cell lung cancer (NSCLC). However… read more here.
Keywords: anti tumor; combination; m6620; tumor ... See more keywords
Preparation, Characterization, and In Vitro Pharmacodynamics and Pharmacokinetics Evaluation of PEGylated Urolithin A Liposomes
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DOI: 10.1208/s12249-020-01890-y
Abstract: Urolithin A (Uro-A), a metabolite of ellagitannins in mammals’ intestinal tract, displays broad biological properties in preclinical models, including anti-oxidant, anti-inflammatory, and anti-tumor effects. However, the clinical application of Uro-A is restricted because of its… read more here.
Keywords: peg lps; uro peg; tumor efficacy; anti tumor ... See more keywords
Corrigendum: Improving anti-tumor efficacy of low-dose Vincristine in rhabdomyosarcoma via the combination therapy with FOXM1 inhibitor RCM1
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DOI: 10.3389/fonc.2023.1163510
Abstract: [This corrects the article DOI: 10.3389/fonc.2023.1112859.]. read more here.
Keywords: anti tumor; corrigendum improving; tumor efficacy; improving anti ... See more keywords
The Combined Anti-Tumor Efficacy of Bioactive Hydroxyapatite Nanoparticles Loaded with Altretamine
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15010302
Abstract: In the current study, the combined anti-tumor efficacy of bioactive hydroxyapatite nano- particles (HA-NPs) loaded with altretamine (ALT) was evaluated. The well-known fact that HA has great biological compatibility was confirmed through the findings of… read more here.
Keywords: anti tumor; alt; tumor efficacy; combined anti ... See more keywords