Integrated Microfluidic Platform with Multiple Functions To Probe Tumor-Endothelial Cell Interaction.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b02593
Abstract: Interaction between tumor and endothelial cells could affect tumor growth and progression and induce drug resistance during cancer therapy. Investigation of tumor-endothelial cell interaction involves cell coculture, protein detection, and analysis of drug metabolites, which… read more here.
Keywords: integrated microfluidic; tumor endothelial; endothelial cells; interaction ... See more keywords
ERK and c-Myc signaling in host-derived tumor endothelial cells is essential for solid tumor growth.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2211927120
Abstract: The limited efficacy of the current antitumor microenvironment strategies is due in part to the poor understanding of the roles and relative contributions of the various tumor stromal cells to tumor development. Here, we describe… read more here.
Keywords: tumor growth; tumor stromal; endothelial cells; erk myc ... See more keywords
Novel antiangiogenic therapy targeting biglycan using tumor endothelial cell-specific liposomal siRNA delivery system.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer science"
DOI: 10.1111/cas.15323
Abstract: Tumor blood vessels play important roles in tumor progression and metastasis. Targeting tumor endothelial cells (TECs) is one of the strategies for cancer therapy. We previously reported that biglycan, a small leucine-rich proteoglycan, is highly… read more here.
Keywords: tumor; tumor endothelial; mend; sirna ... See more keywords
Abstract 584: Doppel, an exosome mediated biomarker specific to tumor endothelial cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-584
Abstract: The difficulty of finding a biomarker that is both specific and ubiquitous in cancer presents a barrier to targeted drug delivery. Some tumor-associated antigens are also found in normal tissue and contribute to “on-target toxicities”.… read more here.
Keywords: endothelial cells; biomarker specific; tumor endothelial; specific tumor ... See more keywords
ROS enhance angiogenic properties via regulation of NRF2 in tumor endothelial cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17567
Abstract: Reactive oxygen species (ROS) are unstable molecules that activate oxidative stress. Because of the insufficient blood flow in tumors, the tumor microenvironment is often exposed to hypoxic condition and nutrient deprivation, which induces ROS accumulation.… read more here.
Keywords: tumor; tumor endothelial; endothelial cells; ros enhance ... See more keywords
Soluble tumor endothelial marker 1 in heart failure with reduced ejection fraction: A pilot study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.1015471
Abstract: Background Tumor endothelial marker 1 (TEM1/CD248) is a transmembrane protein that expresses in mesenchymal lineage derived cells during embryogenesis and becomes undetectable in normal adults after birth. Re-expression of TEM1 is found in organ fibrosis,… read more here.
Keywords: reduced ejection; heart failure; endothelial marker; tumor endothelial ... See more keywords
Cancer-Induced Metabolic Rewiring of Tumor Endothelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14112735
Abstract: Simple Summary Angiogenesis, the formation of new blood vessels from preexisting ones, is a complex and demanding biological process that plays an important role in physiological, as well as pathological conditions, including cancer. During tumor… read more here.
Keywords: endothelial cells; cancer induced; tumor endothelial; angiogenesis ... See more keywords
Metabolic Reprogramming in Tumor Endothelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911052
Abstract: The dynamic crosstalk between the different components of the tumor microenvironment is critical to determine cancer progression, metastatic dissemination, tumor immunity, and therapeutic responses. Angiogenesis is critical for tumor growth, and abnormal blood vessels contribute… read more here.
Keywords: reprogramming tumor; endothelial cells; metabolic reprogramming; tumor endothelial ... See more keywords
CXCR7 silencing inhibits the migration and invasion of human tumor endothelial cells derived from hepatocellular carcinoma by suppressing STAT3.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular medicine reports"
DOI: 10.3892/mmr.2018.9114
Abstract: C-X-C chemokine receptor type 7 (CXCR7) is reported to be overexpressed in tumor endothelial cells (TECs), which are the primary target cells of antivascular chemotherapy. However, the role of CXCR7 in TECs is not fully… read more here.
Keywords: tecs; tumor endothelial; migration invasion; cxcr7 ... See more keywords