Targeted deep sequencing of effusion cytology samples is feasible, informs spatiotemporal tumor evolution, and has clinical and diagnostic utility
Sign Up to like & getrecommendations! Published in 2018 at "Genes"
DOI: 10.1002/gcc.22509
Abstract: During the course of disease, many cancer patients eventually present with metastatic disease including peritoneal or pleural spread. In this context, cytology specimens derived from ascites or pleural effusion may help to differentiate malignant from… read more here.
Keywords: targeted deep; spatiotemporal tumor; tumor evolution; cytology ... See more keywords
Multisite tumor sampling enhances the detection of intratumor heterogeneity at all different temporal stages of tumor evolution
Sign Up to like & getrecommendations! Published in 2017 at "Virchows Archiv"
DOI: 10.1007/s00428-017-2223-y
Abstract: Intratumor heterogeneity (ITH) is an inherent process of tumor development that has received much attention in previous years, as it has become a major obstacle for the success of targeted therapies. ITH is also temporally… read more here.
Keywords: tumor sampling; intratumor heterogeneity; multisite tumor; tumor evolution ... See more keywords
Singling Out Chromosome Gains in Tumor Evolution.
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DOI: 10.1016/j.ccell.2017.01.011
Abstract: In this issue of Cancer Cell, Sheltzer et al. shed new light on Theodor Boveri's century-old hypothesis by demonstrating that aneuploidy characterized by single-chromosome gains acts to suppress tumorigenesis and that aneuploidy itself is a nidus… read more here.
Keywords: singling chromosome; gains tumor; chromosome gains; tumor evolution ... See more keywords
Genomic characterization and tumor evolution in paired samples of metaplastic breast carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Modern Pathology"
DOI: 10.1038/s41379-022-01017-7
Abstract: Metaplastic breast carcinomas are a rare and heterogeneous group of tumors (0.5–2%). They are mainly triple negative tumors but they present poorer chemotherapy responses and worse prognosis than other triple negative tumors. The aim of… read more here.
Keywords: tumor; tumor samples; relapse progression; metaplastic breast ... See more keywords
Lesion-Directed Therapies and Monitoring Tumor Evolution Using Liquid Biopsies.
Sign Up to like & getrecommendations! Published in 2017 at "Cold Spring Harbor perspectives in medicine"
DOI: 10.1101/cshperspect.a029587
Abstract: Precision oncology relies on targeted drugs, such as kinase inhibitors, that are presently administered based on molecular profiles obtained from surgical or bioptic tissue samples. The inherent ability of human tumors to molecularly evolve in… read more here.
Keywords: tumor evolution; liquid biopsies; lesion directed;
Abstract 218: The evolutionary history of 2,658 cancers
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-218
Abstract: Cancer develops through a continuous process of somatic evolution. Whole genome sequencing provides a snapshot of the tumor genome at the point of sampling, however, the data can contain information that permits the reconstruction of… read more here.
Keywords: evolution; time; history; cancer ... See more keywords
Abstract IA26: Tumor evolution: From Darwin’s finches to breast cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.tumhet2020-ia26
Abstract: Tumor evolution is driven by heterogeneity for heritable traits in combination with environmental selection forces including cancer therapies. We have been investigating intratumor cellular genetic and phenotypic heterogeneity in breast tumors and described that higher… read more here.
Keywords: cancer; heterogeneity; tumor evolution; evolution darwin ... See more keywords
Abstract IA14: Breast tumor evolution: The role of the microenvironment
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.advbc17-ia14
Abstract: The immune system and the tissue microenvironment shape tumor evolution by providing selection for cancer cells with certain phenotypes. Immunotherapy is one of the most promising current cancer therapies and one of the very few… read more here.
Keywords: microenvironment; breast; cancer cells; cancer ... See more keywords
Translating insights into tumor evolution to clinical practice: promises and challenges
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DOI: 10.1186/s13073-019-0632-z
Abstract: Accelerating technological advances have allowed the widespread genomic profiling of tumors. As yet, however, the vast catalogues of mutations that have been identified have made only a modest impact on clinical medicine. Massively parallel sequencing… read more here.
Keywords: medicine; evolution; cancer; tumor evolution ... See more keywords
Non-invasive diagnosis and tracking of tumor evolution by targeted sequencing of circulating tumor DNA in metastatic pancreatic cancer patients.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e15769
Abstract: e15769Background: Treatment of stage IV pancreatic ductal adenocarcinoma (PDAC) has made substantial progress over the last years, therapy monitoring still is at an early stage. This could be subst... read more here.
Keywords: invasive diagnosis; tracking tumor; non invasive; tumor evolution ... See more keywords
Small extracellular vesicle DNA-mediated horizontal gene transfer as a driving force for tumor evolution: Facts and riddles
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.945376
Abstract: The basis of the conventional gene-centric view on tumor evolution is that vertically inherited mutations largely define the properties of tumor cells. In recent years, however, accumulating evidence shows that both the tumor cells and… read more here.
Keywords: gene transfer; tumor evolution; gene;