Cyclodextrin-Derived ROS-Generating Nanomedicine with pH-Modulated Degradability to Enhance Tumor Ferroptosis Therapy and Chemotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202200330
Abstract: Nowadays, destruction of redox homeostasis to induce cancer cell death is an emerging anti-cancer strategy. Here, the authors utilized pH-sensitive acetalated β-cyclodextrin (Ac-β-CD) to efficiently deliver dihydroartemisinin (DHA) for tumor ferroptosis therapy and chemodynamic therapy… read more here.
Keywords: tumor ferroptosis; cancer; ferroptosis therapy; ferroptosis ... See more keywords
Biomimetic Molybdenum Sulfide-Catalyzed Tumor Ferroptosis and Bioimaging.
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DOI: 10.1002/smll.202207544
Abstract: The chemical generation of singlet oxygen (1 O2 ) by the MoO4 2- -catalyzed disproportionation of hydrogen peroxide (H2 O2 ) has been widely applied in numerous catalytic processes; however, such molybdate ions cannot be… read more here.
Keywords: tumor ferroptosis; molybdenum sulfide; ferroptosis;
CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4.
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DOI: 10.1016/j.ccell.2022.02.003
Abstract: Tumor cell intrinsic ferroptosis-initiating mechanisms are unknown. Here, we discover that T cell-derived interferon (IFN)γ in combination with arachidonic acid (AA) induces immunogenic tumor ferroptosis, serving as a mode of action for CD8+ T cell (CTL)-mediated tumor… read more here.
Keywords: tumor; ferroptosis; cd8; fatty acids ... See more keywords
Self-catalyzed tumor ferroptosis based on ferrocene conjugated reactive oxygen species generation and a responsive polymer.
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DOI: 10.1039/d1cc06742g
Abstract: In this work, we developed a ferroptosis self-catalyst, PTAF, exhibiting self-catalyzed ferroptosis for enhanced cancer therapy. Briefly, synergistic actions of self-catalyzed ˙OH accumulation and GPX4 indirect inactivation based on the establishment of the ROS self-catalytic… read more here.
Keywords: tumor ferroptosis; catalyzed tumor; self catalyzed; ferroptosis based ... See more keywords