A TIGIT-based chimeric co-stimulatory switch receptor improves T-cell anti-tumor function
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DOI: 10.1186/s40425-019-0721-y
Abstract: BackgroundTumors can employ different mechanisms to evade immune surveillance and function. Overexpression of co-inhibitory ligands that bind to checkpoint molecules on the surface of T-cells can greatly impair the function of latter. TIGIT (T cell… read more here.
Keywords: tigit; tumor function; anti tumor; function ... See more keywords