Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.02.024
Abstract: Adoptive TÂ cell therapy (ACT) produces durable responses in some cancer patients; however, most tumors are refractory to ACT and the molecular mechanisms underlying resistance are unclear. Using two independent approaches, we identified tumor glycolysis as… read more here.
Keywords: glycolysis; tumor glycolysis; adoptive cell; resistance ... See more keywords
Increased tumor glycolysis is associated with decreased immune infiltration across human solid tumors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.880959
Abstract: Response to immunotherapy across multiple cancer types is approximately 25%, with some tumor types showing increased response rates compared to others (i.e. response rates in melanoma and non-small cell lung cancer (NSCLC) are typically 30-60%).… read more here.
Keywords: immune infiltration; tumor; increased tumor; tumor glycolysis ... See more keywords
Phytochemicals as Regulators of Tumor Glycolysis and Hypoxia Signaling Pathways: Evidence from In Vitro Studies
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DOI: 10.3390/ph15070808
Abstract: The full understanding of the complex nature of cancer still faces many challenges, as cancers arise not as a result of a single target disruption but rather involving successive genetic and epigenetic alterations leading to… read more here.
Keywords: vitro studies; tumor glycolysis; regulators tumor; evidence ... See more keywords