Secretogranin II impairs tumor growth and angiogenesis by promoting degradation of hypoxia-inducible factor-1α in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13044
Abstract: Distant metastasis is a major cause of death in patients with colorectal cancer (CRC), but the management of advanced and metastatic CRC still remains problematic due to the distinct molecular alterations during tumor progression. Tumor… read more here.
Keywords: tumor; factor; crc; scg2 ... See more keywords
MiR‐409‐3p regulates cell proliferation and tumor growth by targeting E74‐like factor 2 in osteosarcoma
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12177
Abstract: Recent evidence has shown that miR‐409‐3p was down‐regulated in several types of cancer, including osteosarcoma. However, the potential role of miR‐409‐3p in osteosarcoma remains largely unknown. In the present study, we showed that overexpression of… read more here.
Keywords: cell proliferation; mir 409; osteosarcoma; tumor growth ... See more keywords
A Novel Tri‐Functional Liposome Re‐Educates “Cold Tumor” and Abrogates Tumor Growth by Synergizing Autophagy Inhibition and PD‐L1 Blockade
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202757
Abstract: Immunotherapy has been regarded as a breakthrough in cancer treatment and achieved great success. However, the poor response rate is still a formidable challenge of current immunotherapies, especially in solid tumors without sufficient infiltration of… read more here.
Keywords: tumor growth; cold tumor; dox; novel tri ... See more keywords
The maximum tumor growth rate predicts clinical outcomes of patients with small‐cell lung cancer undergoing first‐line chemotherapy plus immune‐checkpoint inhibitor therapy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5611
Abstract: Currently, no biomarkers can accurately predict survival outcomes in patients with SCLC undergoing treatment. Tumor growth rate (TGR; percent size change per month [%/m]) is suggested as an imaging predictor of response to anti‐cancer treatment.… read more here.
Keywords: outcomes patients; tumor growth; small cell; growth rate ... See more keywords
Immune-check blocking combination multiple cytokines shown curative potential in mice tumor model.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6053
Abstract: OBJECTIVE In order to ensure the stable transcription of target genes, we constructed a eukaryotic high expression vector carrying an immune-check inhibitor PD-1v and a variety of cytokines, and studied their effects on activating immune… read more here.
Keywords: mice tumor; tumor growth; combination; tumor ... See more keywords
An approach for vascular tumor growth based on a hybrid embedded/homogenized treatment of the vasculature within a multiphase porous medium model.
Sign Up to like & getrecommendations! Published in 2019 at "International journal for numerical methods in biomedical engineering"
DOI: 10.1002/cnm.3253
Abstract: The aim of this work is to develop a novel computational approach to facilitate the modeling of angiogenesis during tumor growth. The pre-existing vasculature is modeled as a one-dimensional inclusion and embedded into the three-dimensional… read more here.
Keywords: tumor; vasculature; model; multiphase ... See more keywords
Early decision making in a randomized phase II trial of atezolizumab in biliary tract cancer using a tumor growth inhibition-survival modeling framework.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2953
Abstract: We assess the longitudinal tumor growth inhibition (TGI) metrics and overall survival (OS) predictions applied to patients with advanced biliary tract cancer (BTC) enrolled in IMbrave151 a multicenter randomized phase II, double-blind, placebo-controlled trial evaluating… read more here.
Keywords: tumor growth; trial; growth inhibition; phase ... See more keywords
NOD‐like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30693
Abstract: Nonalcoholic fatty liver disease (NAFLD) enhances the growth and recurrence of colorectal cancer (CRC) liver metastasis. With the rising prevalence of NAFLD, a better understanding of the molecular mechanism underlying NAFLD‐associated liver metastasis is crucial.… read more here.
Keywords: tumor growth; growth; liver metastasis; liver ... See more keywords
Inhibition of MYC attenuates tumor cell self‐renewal and promotes senescence in SMARCB1‐deficient Group 2 atypical teratoid rhabdoid tumors to suppress tumor growth in vivo
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.31873
Abstract: Loss of SMARCB1 is the hallmark genetic event that characterizes rhabdoid tumors in children. Rhabdoid tumors of the brain (ATRT) occur in young children and are particularly challenging with poor long‐term survival. SMARCB1 is a… read more here.
Keywords: rhabdoid tumors; tumor; inhibition; cell ... See more keywords
Disruption of sialic acid metabolism drives tumor growth by augmenting CD8+ T cell apoptosis
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32084
Abstract: Sialylated glycan structures are known for their immunomodulatory capacities and their contribution to tumor immune evasion. However, the role of aberrant sialylation in colorectal cancer and the consequences of complete tumor desialylation on anti‐tumor immunity… read more here.
Keywords: cd8 cell; tumor; cancer; cell ... See more keywords
Abrogating GPT2 in triple‐negative breast cancer inhibits tumor growth and promotes autophagy
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Cancer"
DOI: 10.1002/ijc.33456
Abstract: Uncontrolled proliferation and altered metabolic reprogramming are hallmarks of cancer. Active glycolysis and glutaminolysis are characteristic features of these hallmarks and required for tumorigenesis. A fine balance between cancer metabolism and autophagy is a prerequisite… read more here.
Keywords: negative breast; breast; breast cancer; cancer ... See more keywords