Quantitative tumor heterogeneity assessment on a nuclear population basis
Sign Up to like & getrecommendations! Published in 2017 at "Cytometry Part A"
DOI: 10.1002/cyto.a.23047
Abstract: Immunohistochemistry Ki‐67 stain is widely used for visualizing cell proliferation. The common method for scoring the proliferation is to manually select and score a hot spot. This method is time‐consuming and will often not give… read more here.
Keywords: heterogeneity assessment; quantitative tumor; nuclear population; tumor heterogeneity ... See more keywords
Genetics of Hepatocellular Carcinoma: Approaches to Explore Molecular Diversity
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31394
Abstract: Hepatocellular carcinomas (HCCs) are highly heterogeneous malignancies with different risk factors, including alcohol abuse, chronic hepatitis B (HBV) and C (HCV) infection, fatty liver disease and other genetic disorders. Despite recent progress in HCC management,… read more here.
Keywords: tumor heterogeneity; genetics; molecular diversity; hcc ... See more keywords
Deep learning image analysis quantifies tumor heterogeneity and identifies microsatellite instability in colon cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.27118
Abstract: Deep learning utilizing convolutional neural networks (CNNs) applied to hematoxylin & eosin (H&E)‐stained slides numerically encodes histomorphological tumor features. Tumor heterogeneity is an emerging biomarker in colon cancer that is, captured by these features, whereas… read more here.
Keywords: tumor heterogeneity; colon cancer; microsatellite instability; deep learning ... See more keywords
Tumor heterogeneity.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer cell"
DOI: 10.1016/j.ccell.2021.07.009
Abstract: Tumor heterogeneity was traditionally considered in the genetic terms, but it has now been broadened into many more facets. These facets represent a challenge in our understanding of cancer etiology but also provide opportunity for… read more here.
Keywords: tumor heterogeneity; etiology; tumor;
Mutant‐Allele Tumor Heterogeneity Scores Correlate With Risk of Metastases in Colon Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Colorectal Cancer"
DOI: 10.1016/j.clcc.2016.11.004
Abstract: Background: Colorectal cancer is a leading cause of cancer‐related mortality, has a very broad mutational spectrum, and there is no clinically available biomarker that can predict which patients with stage II or stage III colorectal… read more here.
Keywords: risk; heterogeneity; colon cancer; cancer ... See more keywords
A09 Transcriptional Subtypes Resolve Tumor Heterogeneity and Identify Therapeutic Vulnerabilities in Lung Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2019.12.038
Abstract: KRASG12C(ON) inhibitors with agents targeting pathway nodes both upand downstream of RAS, as well as other parallel pathways, can drive combination benefit in distinct cancer histotypes. Tri-complex inhibitors that target the active, GTP-bound form of… read more here.
Keywords: cancer; subtypes resolve; transcriptional subtypes; a09 transcriptional ... See more keywords
Pre-analytics and tumor heterogeneity.
Sign Up to like & getrecommendations! Published in 2019 at "New biotechnology"
DOI: 10.1016/j.nbt.2019.09.007
Abstract: When dealing with pre-analytics for tissues, it is often that case that tissue heterogeneity, and particularly tumor heterogeneity, is not taken into account as a preliminary condition for obtaining reproducible results in molecular analysis at… read more here.
Keywords: heterogeneity; pre analytics; analytics tumor; tumor heterogeneity ... See more keywords
Untargeted Metabolomic Characterization of Glioblastoma Intra-Tumor Heterogeneity Using OrbiSIMS
Sign Up to like & getrecommendations! Published in 2023 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.2c05807
Abstract: Glioblastoma (GBM) is an incurable brain cancer with a median survival of less than two years from diagnosis. The standard treatment of GBM is multimodality therapy comprising surgical resection, radiation, and chemotherapy. However, prognosis remains… read more here.
Keywords: tumor heterogeneity; gbm; tumor; intra tumor ... See more keywords
NanoRNP Overcomes Tumor Heterogeneity in Cancer Treatment.
Sign Up to like & getrecommendations! Published in 2019 at "Nano letters"
DOI: 10.1021/acs.nanolett.9b02501
Abstract: Tumor heterogeneity has been one of the most important factors leading to the failure of conventional cancer therapies due to the accumulation of genetically distinct tumor-cell subpopulations during tumor development process. Due to the diversity… read more here.
Keywords: heterogeneity cancer; tumor heterogeneity; nanornp overcomes; tumor ... See more keywords
Metastatic adrenocortical carcinoma displays higher mutation rate and tumor heterogeneity than primary tumors
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06366-z
Abstract: Adrenocortical cancer (ACC) is a rare cancer with poor prognosis and high mortality due to metastatic disease. All reported genetic alterations have been in primary ACC, and it is unknown if there is molecular heterogeneity… read more here.
Keywords: heterogeneity; mutation rate; higher mutation; tumor heterogeneity ... See more keywords
Deciphering brain tumor heterogeneity, one cell at a time
Sign Up to like & getrecommendations! Published in 2019 at "Nature Medicine"
DOI: 10.1038/s41591-019-0605-1
Abstract: Single-cell RNA sequencing characterizes clonal dynamics and distinct cellular states contributing to intratumoral heterogeneity in glioblastoma and medulloblastoma. read more here.
Keywords: heterogeneity one; heterogeneity; deciphering brain; brain tumor ... See more keywords