Tuning the Hydrophilic - Hydrophobic Balance of Molecular Polymer Bottlebrushes Enhances their Tumor Homing Properties.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202200163
Abstract: Nanoparticle (NP)-based drug delivery systems are promising in anti-cancer therapy, capable of delivering cargo with superior selectivity and achieving enhanced tumor accumulation compared to small-molecule therapeutics. As more efforts are being devoted to NP development,… read more here.
Keywords: tumor; hydrophilic hydrophobic; molecular polymer; hydrophobic balance ... See more keywords
Synthesis and evaluation of tumor-homing peptides for targeting prostate cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Amino acids"
DOI: 10.1007/s00726-021-02971-3
Abstract: High toxicity caused by chemotherapeutic drugs and the acquisition of drug resistance by cancer cells are the major drawbacks in cancer therapy. A promising approach to overcome the posed barriers is conjugating tumor-homing peptides to… read more here.
Keywords: homing peptides; tumor homing; prostate cancer; cancer cells ... See more keywords
Molecular hybridization combining tumor homing and penetrating peptide domains for cellular targeting.
Sign Up to like & getrecommendations! Published in 2021 at "Drug delivery and translational research"
DOI: 10.1007/s13346-021-01035-z
Abstract: A complete peptide-based drug delivery unit has been designed with a tumor homing domain chemically linked to a syndiotactic cell-penetrating domain. The designed peptides were synthesized, characterized, and tested in vitro for cellular uptake and… read more here.
Keywords: peptide; tumor homing; combining tumor; molecular hybridization ... See more keywords
Boarding Oncolytic Viruses onto Tumor-Homing Bacterium-Vessels for Augmented Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c00699
Abstract: Oncolytic viruses (OVs) have been widely used as anticancer therapeutics because of their systemic immune responses during viral replication. However, the low enrichment of OVs within tumors and limited immune activation have hindered their clinical… read more here.
Keywords: tumor homing; onto tumor; oas; oncolytic viruses ... See more keywords
Tumor-Homing and Immune-Reprogramming Cellular Nanovesicles for Photoacoustic Imaging-Guided Phototriggered Precise Chemoimmunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c04983
Abstract: Many studies have focused on developing effective therapeutic strategies to selectively destroy primary tumors, eliminate metastatic lesions, and prevent tumor recurrence with minimal side effects on normal tissues. In this work, we synthesized engineered cellular… read more here.
Keywords: tumor homing; homing immune; cellular nanovesicles; immune reprogramming ... See more keywords
A novel tumor-homing TRAIL variant eradicates tumor xenografts of refractory colorectal cancer cells in combination with tumor cell-targeted photodynamic therapy
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2079766
Abstract: Abstract Multidrug resistance (MDR), which is common in colorectal cancer (CRC), induces high mortality in patients. Due to its robust and selective apoptosis induction in some CRC cells with MDR, tumor necrosis factor-related apoptosis-inducing ligand… read more here.
Keywords: tumor homing; trail; therapy; crc ... See more keywords
HER3-targeted protein chimera forms endosomolytic capsomeres and self-assembles into stealth nucleocapsids for systemic tumor homing of RNA interference in vivo
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz900
Abstract: Abstract RNA interference represents a potent intervention for cancer treatment but requires a robust delivery agent for transporting gene-modulating molecules, such as small interfering RNAs (siRNAs). Although numerous molecular approaches for siRNA delivery are adequate… read more here.
Keywords: her3; chimera; rna interference; tumor homing ... See more keywords
A Novel Network Science and Similarity-Searching-Based Approach for Discovering Potential Tumor-Homing Peptides from Antimicrobials
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DOI: 10.3390/antibiotics11030401
Abstract: Peptide-based drugs are promising anticancer candidates due to their biocompatibility and low toxicity. In particular, tumor-homing peptides (THPs) have the ability to bind specifically to cancer cell receptors and tumor vasculature. Despite their potential to… read more here.
Keywords: tumor homing; thps; homing peptides; similarity ... See more keywords