Synthetic Matrix Scaffolds Engineer the In Vivo Tumor Immune Microenvironment for Immunotherapy Screening
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202108084
Abstract: Immunotherapy has emerged as one of the most powerful anti‐cancer therapies but is stymied by the limits of existing preclinical models with respect to disease latency and reproducibility. Additionally, the influence of differing immune microenvironments… read more here.
Keywords: tumor; immunotherapy; tumor immune; immune microenvironment ... See more keywords
Rapid Profiling of Tumor‐Immune Interaction Using Acoustically Assembled Patient‐Derived Cell Clusters
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201478
Abstract: Tumor microenvironment crosstalk, in particular interactions between cancer cells, T cells, and myeloid‐derived suppressor cells (MDSCs), mediates tumor initiation, progression, and response to treatment. However, current patient‐derived models such as tumor organoids and 2D cultures… read more here.
Keywords: cell; acoustically assembled; tumor immune; patient derived ... See more keywords
Tumor immune microenvironment in therapy‐naive esophageal adenocarcinoma could predict the nodal status
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5386
Abstract: Currently, preoperative staging of esophageal adenocarcinoma (EAC) has modest reliability and accuracy for pT and pN stages prediction, which heavily affects overall survival. The interplay among immune checkpoints, oncogenes, and intratumoral and peritumoral immune infiltrating… read more here.
Keywords: therapy naive; immune microenvironment; tumor immune; microenvironment therapy ... See more keywords
THE INFLUENCE OF TUMOR IMMUNE MICROENVIRONMENT AND TUMOR IMMUNITY ON THE PATHOGENESIS, TREATMENT AND PROGNOSIS OF POST‐TRANSPLANT LYMPHOPROLIFERATIVE DISORDERS (PTLD)
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.15_2630
Abstract: 151 THE INFLUENCE OF TUMOR IMMUNE MICROENVIRONMENT AND TUMOR IMMUNITY ON THE PATHOGENESIS, TREATMENT AND PROGNOSIS OF POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDERS (PTLD) H. Saito | H. Shibayama | H. Miyoshi | J. Toda | S. Kusakabe… read more here.
Keywords: medicine; hematology; influence tumor; tumor immune ... See more keywords
The synergistic strategies for the immuno-oncotherapy with photothermal nanoagents.
Sign Up to like & getrecommendations! Published in 2021 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1717
Abstract: Immuno-oncotherapy has shown great promise for the cure of late-stage and metastatic cancer. Great efforts have tried to improve the overall response rate (ORR) and to reduce the immune-related adverse events (irAEs). Antigen presentation, T… read more here.
Keywords: immune responses; anti tumor; tumor immune; immuno oncotherapy ... See more keywords
Noninvasive evaluation of tumor immune microenvironment in patients with clear cell renal cell carcinoma using metabolic parameter from preoperative 2-[18F]FDG PET/CT
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-021-05399-9
Abstract: Nowadays, it is necessary to explore effective biomarkers associated with tumor immune microenvironment (TIME) noninvasively. Here, we investigated whether the metabolic parameter from preoperative 2-[18F]FDG PET/CT could provide information related to TIME in patients with… read more here.
Keywords: immune microenvironment; tumor immune; 18f fdg; fdg pet ... See more keywords
Emerging Biomimetic Materials for Studying Tumor and Immune Cell Behavior
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Biomedical Engineering"
DOI: 10.1007/s10439-019-02384-0
Abstract: Cancer is one of the leading causes of death both in the United States and worldwide. The dynamic microenvironment in which tumors grow consists of fibroblasts, immune cells, extracellular matrix (ECM), and cytokines that enable… read more here.
Keywords: immune cell; cell behavior; cell; tumor immune ... See more keywords
HIF1A expression correlates with increased tumor immune and stromal signatures and aggressive phenotypes in human cancers
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DOI: 10.1007/s13402-020-00534-4
Abstract: Although many studies have revealed essential roles of HIF1A (hypoxia inducible factor 1 subunit alpha) in regulating various pathways associated with cancer development, a systematic investigation of associations of HIF1A expression with tumor immunity, the… read more here.
Keywords: hif1a expression; expression; tumor immune; cancer ... See more keywords
Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient
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DOI: 10.1016/j.cell.2017.07.025
Abstract: Summary We present an exceptional case of a patient with high-grade serous ovarian cancer, treated with multiple chemotherapy regimens, who exhibited regression of some metastatic lesions with concomitant progression of other lesions during a treatment-free… read more here.
Keywords: heterogeneous tumor; ovarian cancer; tumor immune; immune microenvironments ... See more keywords
Cell Cycle Checkpoints Cooperate to Suppress DNA and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses
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DOI: 10.1016/j.celrep.2020.108080
Abstract: SUMMARY The DNA-dependent pattern recognition receptor, cGAS (cyclic GMP-AMP synthase), mediates communication between the DNA damage and the immune responses. Mitotic chromosome missegregation stimulates cGAS activity; however, it is unclear whether progression through mitosis is… read more here.
Keywords: pattern recognition; dna; immune responses; cell cycle ... See more keywords
High versus low dose irradiation for tumor immune reprogramming.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2020.08.001
Abstract: Local administration of ionizing radiation to tumors can promote anticancer immune responses that lead to the abscopal regression of distant metastases, especially in patients receiving systemic immune-checkpoint inhibitors. Growing preclinical evidence indicates that high-dose irradiation… read more here.
Keywords: irradiation; low dose; immune reprogramming; tumor immune ... See more keywords