Synthetic Matrix Scaffolds Engineer the In Vivo Tumor Immune Microenvironment for Immunotherapy Screening
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202108084
Abstract: Immunotherapy has emerged as one of the most powerful anti‐cancer therapies but is stymied by the limits of existing preclinical models with respect to disease latency and reproducibility. Additionally, the influence of differing immune microenvironments… read more here.
Keywords: tumor; immunotherapy; tumor immune; immune microenvironment ... See more keywords
Rapid Profiling of Tumor‐Immune Interaction Using Acoustically Assembled Patient‐Derived Cell Clusters
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DOI: 10.1002/advs.202201478
Abstract: Tumor microenvironment crosstalk, in particular interactions between cancer cells, T cells, and myeloid‐derived suppressor cells (MDSCs), mediates tumor initiation, progression, and response to treatment. However, current patient‐derived models such as tumor organoids and 2D cultures… read more here.
Keywords: cell; acoustically assembled; tumor immune; patient derived ... See more keywords
M6A‐mediated upregulation of lncRNA TUG1 in liver cancer cells regulates the antitumor response of CD8+ T cells and phagocytosis of macrophages
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DOI: 10.1002/advs.202400695
Abstract: Tumor immune evasion relies on the crosstalk between tumor cells and adaptive/innate immune cells. Immune checkpoints play critical roles in the crosstalk, and immune checkpoint inhibitors have achieved promising clinical effects. The long non‐coding RNA… read more here.
Keywords: tumor immune; cd8 cells; tug1; tumor ... See more keywords
Immune Checkpoints in B Cells: Unlocking New Potentials in Cancer Treatment
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DOI: 10.1002/advs.202403423
Abstract: B cells are crucial component of humoral immunity, and their role in the tumor immune microenvironment (TME) has garnered significant attention in recent years. These cells hold great potential and application prospects in the field… read more here.
Keywords: tumor immune; checkpoints cells; tumor; cell ... See more keywords
Single-Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma.
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DOI: 10.1002/advs.202507705
Abstract: Tryptophan metabolism plays a critical role in glioblastoma (GBM), however, the regulatory functions of kynurenic acid (KYNA) in this context remain poorly understood. Using an in-house clinical cohort, targeted metabolomic analysis revealed significantly downregulated KYNA… read more here.
Keywords: tumor immune; single cell; glioblastoma; tumor ... See more keywords
Core Fucosylation Represses SMURF1-Dependent Degradation of CD47 to Promote Tumor Immune Evasion.
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DOI: 10.1002/advs.202516863
Abstract: Glycosylation, the covalent attachment of glycans to proteins, lipids, and RNAs, is fundamental in regulating diverse biological processes. Glycosylation patterns are aberrantly altered in the tumor microenvironment and closely associated with tumor immune escape. However,… read more here.
Keywords: tumor immune; tumor; cd47; core fucosylation ... See more keywords
Tumor immune microenvironment in therapy‐naive esophageal adenocarcinoma could predict the nodal status
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5386
Abstract: Currently, preoperative staging of esophageal adenocarcinoma (EAC) has modest reliability and accuracy for pT and pN stages prediction, which heavily affects overall survival. The interplay among immune checkpoints, oncogenes, and intratumoral and peritumoral immune infiltrating… read more here.
Keywords: therapy naive; immune microenvironment; tumor immune; microenvironment therapy ... See more keywords
Fc receptor‐like A promotes malignant behavior in renal cell carcinoma and correlates with tumor immune infiltration
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DOI: 10.1002/cam4.70072
Abstract: Our study aims to investigate the mechanisms through which Fc receptor‐like A (FCRLA) promotes renal cell carcinoma (RCC) and to examine its significance in relation to tumor immune infiltration. read more here.
Keywords: tumor immune; receptor like; immune infiltration; cell carcinoma ... See more keywords
THE INFLUENCE OF TUMOR IMMUNE MICROENVIRONMENT AND TUMOR IMMUNITY ON THE PATHOGENESIS, TREATMENT AND PROGNOSIS OF POST‐TRANSPLANT LYMPHOPROLIFERATIVE DISORDERS (PTLD)
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.15_2630
Abstract: 151 THE INFLUENCE OF TUMOR IMMUNE MICROENVIRONMENT AND TUMOR IMMUNITY ON THE PATHOGENESIS, TREATMENT AND PROGNOSIS OF POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDERS (PTLD) H. Saito | H. Shibayama | H. Miyoshi | J. Toda | S. Kusakabe… read more here.
Keywords: medicine; hematology; influence tumor; tumor immune ... See more keywords
A Novel Multicompartment Barrier-Free Microfluidic Device Reveals the Impact of Extracellular Matrix Stiffening and Temozolomide on Immune-Tumor Interactions in Glioblastoma.
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DOI: 10.1002/smll.202409229
Abstract: The immune system plays a crucial role in shaping the glioblastoma tumor microenvironment, characterized by its complexity and dynamic interactions. Understanding the tumor-immune crosstalk is essential for advancing cancer research and therapeutic development. Here, a… read more here.
Keywords: matrix; tumor immune; device; tumor ... See more keywords
The synergistic strategies for the immuno-oncotherapy with photothermal nanoagents.
Sign Up to like & getrecommendations! Published in 2021 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1717
Abstract: Immuno-oncotherapy has shown great promise for the cure of late-stage and metastatic cancer. Great efforts have tried to improve the overall response rate (ORR) and to reduce the immune-related adverse events (irAEs). Antigen presentation, T… read more here.
Keywords: immune responses; anti tumor; tumor immune; immuno oncotherapy ... See more keywords