Personalized Bacteria Loaded with Autoantigens for the Enhancement of Tumor Immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202203026
Abstract: Currently, tumor immunotherapy is becoming a new revolution in tumor treatment. Generated from tumor cell lysate (TCL) or irradiated tumor cells, the whole tumor antigen‐based vaccines have the possibility to enhance antitumor immune response without… read more here.
Keywords: personalized bacteria; bacteria loaded; immunotherapy; ens pda ... See more keywords
Responsive Multivesicular Polymeric Nanovaccines that Codeliver STING Agonists and Neoantigens for Combination Tumor Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201895
Abstract: Immune checkpoint blockade (ICB) has significantly advanced cancer immunotherapy, yet its patient response rates are generally low. Vaccines, including immunostimulant‐adjuvanted peptide antigens, can improve ICB. The emerging neoantigens generated by cancer somatic mutations elicit cancer‐specific… read more here.
Keywords: combination tumor; immunotherapy; combination; tumor immunotherapy ... See more keywords
Neutrophil Camouflaged Stealth Nanovehicle for Photothermal‐Induced Tumor Immunotherapy by Triggering Pyroptosis
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202207456
Abstract: The regulation of tumor immunosuppressive microenvironments via precise drug delivery is a promising strategy for preventing tumor recurrence and metastasis. Inspired by the stealth strategy, a stealthy nanovehicle based on neutrophil camouflage is developed to… read more here.
Keywords: pyroptosis; nanovehicle; tumor immunotherapy; immunotherapy triggering ... See more keywords
Enhancement of CD8+ T Cells-mediated Tumor Immunotherapy via Magnetic Hyperthermia.
Sign Up to like & getrecommendations! Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202100656
Abstract: Magnetic hyperthermia (MHT) uses magnetic iron oxide nanoparticles (MIONs) to irradiate heat when subjected to an alternating magnetic field (AMF), which then trigger a series of biological effects to realize rapid tumor-killing effects. With the… read more here.
Keywords: tumor immunotherapy; immunotherapy; mht; magnetic hyperthermia ... See more keywords
Nano Delivery of Chemotherapeutic ICD Inducers for Tumor Immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Small Methods"
DOI: 10.1002/smtd.202201307
Abstract: Immunogenic cell death (ICD, also known as immunogenic apoptosis) of malignant cells is confirmed to activate the host immune system to prevent, control, and eliminate tumors. Recently, a range of chemotherapeutic drugs have been repurposed… read more here.
Keywords: chemotherapeutic icd; icd; nano delivery; tumor immunotherapy ... See more keywords
Overcoming biological barriers to improve solid tumor immunotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Drug delivery and translational research"
DOI: 10.1007/s13346-021-00923-8
Abstract: Cancer immunotherapy has been at the forefront of therapeutic interventions for many different tumor types over the last decade. While the discovery of immunotherapeutics continues to occur at an accelerated rate, their translation is often… read more here.
Keywords: tumor immunotherapy; tumor; biological barriers; solid tumor ... See more keywords
Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy
Sign Up to like & getrecommendations! Published in 2017 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2017.02.004
Abstract: Programmed Cell Death-1 (PD-1) is an inhibitory immune receptor, which plays critical roles in T cell co-inhibition and exhaustion upon binding to its ligands PD-L1 and PD-L2. We report the crystal structure of the human… read more here.
Keywords: tumor immunotherapy; high affinity; affinity; programmed cell ... See more keywords
Nanoparticles for tumor immunotherapy
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2017.03.013
Abstract: &NA; Although most researches and therapies have been focused on the tumor itself, it is becoming clear that immune cells can not only suppress tumor development but support and maintain their malignant type. Promising recent… read more here.
Keywords: tumor immunotherapy; system; nanoparticles tumor; cancer ... See more keywords
NK cells and ILCs in tumor immunotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular aspects of medicine"
DOI: 10.1016/j.mam.2020.100870
Abstract: Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity against tumors, different approaches have been developed… read more here.
Keywords: cells ilcs; tumor immunotherapy; cells may; cell ... See more keywords
Tumor immunotherapy - A lot to learn from Keratoacanthoma.
Sign Up to like & getrecommendations! Published in 2020 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2020.109719
Abstract: Dysfunctionalinty and exhaustion of T cells in the tumor microenvironment is a harsh reality of anti-tumor immune response where tumor cells can escape it. A considerable effort is going on in the field of research… read more here.
Keywords: tumor immunotherapy; immunotherapy lot; immune response; cancer ... See more keywords
Genetic Engineering of Dendritic Cells Using Partially Zwitterionic Dendrimer-Entrapped Gold Nanoparticles Boosts Efficient Tumor Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.1c01571
Abstract: Effective processing and cross-priming of tumor neoantigen by dendritic cells (DCs) to T cells for spontaneous immune response generation to effectively kill cancer cells remain challenging in cancer immunotherapy. Here, we report a general approach… read more here.
Keywords: gold nanoparticles; immunotherapy; entrapped gold; dendritic cells ... See more keywords