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   Articles with "tumor initiating" as a keyword



The Dual Role of the NFATc2/galectin‐9 Axis in Modulating Tumor‐Initiating Cell Phenotypes and Immune Suppression in Lung Adenocarcinoma

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202306059

Abstract: Tumor‐initiating cells (TICs) resilience and an immunosuppressive microenvironment are aggressive oncogenic phenotypes that contribute to unsatisfactory long‐term outcomes in lung adenocarcinoma (LUAD) patients. The molecular mechanisms mediating the interaction between TICs and immune tolerance have… read more here.

Keywords: galectin; role; lung adenocarcinoma; tumor initiating ... See more keywords

Regulatory T cells inhibit FoxP3 to increase the population of tumor initiating cells in hepatocellular carcinoma

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recommendations! Published in 2024 at "Journal of Cancer Research and Clinical Oncology"

DOI: 10.1007/s00432-024-05892-2

Abstract: Tumor initiating cells (TICs) or cancer stem cells (CSCs) are considered to be the main culprit of hepatocellular carcinoma (HCC) initiation and progression, nevertheless the mechanism by which tumor microenvironment maintains the HCC ‘stemness’ is… read more here.

Keywords: hcc; hepatocellular carcinoma; tumor; tumor initiating ... See more keywords

Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells

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recommendations! Published in 2019 at "Journal of Neuro-Oncology"

DOI: 10.1007/s11060-019-03192-1

Abstract: PurposeGlioblastoma (GBM) is the most aggressive adult brain cancer, with a 15 month median survivorship attributed to the existence of treatment-refractory brain tumor initiating cells (BTICs). In order to better understand the mechanisms regulating the tumorigenic… read more here.

Keywords: tumor initiating; brain tumor; stem; brain ... See more keywords
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NRF2/SHH signaling cascade promotes tumor-initiating cell lineage and drug resistance in hepatocellular carcinoma.

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recommendations! Published in 2020 at "Cancer letters"

DOI: 10.1016/j.canlet.2020.02.008

Abstract: Solid evidence shows that tumor-initiating cells (T-ICs) are the root of tumor relapse and drug resistance, which lead to a poor prognosis in patients with hepatocellular carcinoma (HCC). Through an in vitro liver T-IC enrichment… read more here.

Keywords: drug resistance; hepatocellular carcinoma; tumor initiating; nrf2 shh ... See more keywords

A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs

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recommendations! Published in 2019 at "Stem Cell Reports"

DOI: 10.1016/j.stemcr.2018.12.002

Abstract: Summary Tumor-initiating cells (TICs) contribute to drug resistance and tumor recurrence in cancers, thus experimental approaches to dissect the complexity of TICs are required to design successful TIC therapeutic strategies. Here, we show that miRNA-3′… read more here.

Keywords: dissect complexity; tumor initiating; mirna targeting; identify mirna ... See more keywords
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microRNA-29a regulates liver tumor-initiating cells expansion via Bcl-2 pathway.

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recommendations! Published in 2019 at "Experimental cell research"

DOI: 10.1016/j.yexcr.2019.111781

Abstract: MicroRNAs (miRNAs) participate in tumorigenesis, progression, recurrence and drug resistance of hepatocellular carcinoma (HCC). However, few miRNAs have been identified and entered clinical practice. Herein, we report that miR-29a is downregulated in tumor-initiating cells (T-ICs)… read more here.

Keywords: mir 29a; expansion; tumor initiating; initiating cells ... See more keywords

Nanoplatform to Investigate Tumor-Initiating Cancer Stem Cells: Breaking the Diagnostic Barrier.

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recommendations! Published in 2022 at "ACS applied materials & interfaces"

DOI: 10.1021/acsami.1c21998

Abstract: Drug-resistant capacity in a small population of tumor-initiating cancer stem cells (tiCSCs) can be due to aberrant epigenetic changes. However, currently available conventional detection methods are inappropriate and cannot be applied to investigate the scarce… read more here.

Keywords: tumor initiating; cancer stem; initiating cancer; nanoplatform investigate ... See more keywords
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Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers

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recommendations! Published in 2020 at "Nature Communications"

DOI: 10.1038/s41467-020-19593-0

Abstract: Transcriptional dysregulation, which can be caused by genetic and epigenetic alterations, is a fundamental feature of many cancers. A key cytoprotective transcriptional activator, NRF2, is often aberrantly activated in non-small cell lung cancers (NSCLCs) and… read more here.

Keywords: activated non; tumor initiating; non small; nrf2 activated ... See more keywords

Identification and Characterization of Tumor-Initiating Cells in Multiple Myeloma.

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recommendations! Published in 2019 at "Journal of the National Cancer Institute"

DOI: 10.1093/jnci/djz159

Abstract: BACKGROUND Treatment failures in cancers, including multiple myeloma (MM) are most likely due to the persistence of a minor population of tumor initiating cells (TICs), which are non-cycling or slowly-cycling and very drug-resistant. METHODS Gene… read more here.

Keywords: cd24 cells; tumor initiating; initiating cells; multiple myeloma ... See more keywords
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STEM-06. TISSUE FACTOR SIGNALING IN GLIOBLASTOMA TUMOR-INITIATING CELLS

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recommendations! Published in 2019 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noz175.980

Abstract: Glioblastoma (GBM) is an aggressive form of brain cancer with few treatment options, characterized by over-activation of receptor tyrosine kinases (RTKs). Brain tumor-initiating cells (BTICs) is a subpopulation of cells in GBM which have the… read more here.

Keywords: tumor initiating; initiating cells; tissue factor; stem tissue ... See more keywords

The role of CD44 in Tumor-initiating Cells of Salivary Gland Pleomorphic Adenoma: more than a surface biomarker.

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recommendations! Published in 2020 at "Oral diseases"

DOI: 10.1111/odi.13279

Abstract: CD44, a cell-surface glycoprotein, functions as a receptor for hyaluronic acid. Our research group has previously shown that CD44 is a biomarker for the CD44hi cells (tumor-initiating cells; TICs) in murine salivary gland tumors. However,… read more here.

Keywords: tumor initiating; biomarker; pleomorphic adenoma; cd44 ... See more keywords