Fatty Acid Mediators in the Tumor Microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-43093-1_8
Abstract: Patients with cancer frequently overexpress inflammatory cytokines with an associated neutrophilia both of which may be downregulated by diets with high omega-3 polyunsaturated fatty acids (ω-3 PUFA). The anti-inflammatory activity of dietary ω-3 PUFA has… read more here.
Keywords: fatty acid; tumor initiation; initiation progression; acid mediators ... See more keywords
Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.11.002
Abstract: Although metabolic adaptations have been demonstrated to be essential for tumor cell proliferation, the metabolic underpinnings of tumor initiation are poorly understood. We found that the earliest stages of colorectal cancer (CRC) initiation are marked… read more here.
Keywords: initiation; tumor initiation; pyruvate carrier; mitochondrial pyruvate ... See more keywords
Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis
Sign Up to like & getrecommendations! Published in 2017 at "OncoImmunology"
DOI: 10.1080/2162402x.2016.1267892
Abstract: ABSTRACT The cytokine-induced SH2-containing protein CIS belongs to the suppressor of cytokine signaling (SOCS) protein family. Here, we show the critical role of CIS in suppressing natural killer (NK) cell control of tumor initiation and… read more here.
Keywords: cis; cytokine signaling; metastasis; tumor initiation ... See more keywords
AFF4 promotes tumorigenesis and tumor-initiation capacity of head and neck squamous cell carcinoma cells by regulating SOX2
Sign Up to like & getrecommendations! Published in 2018 at "Carcinogenesis"
DOI: 10.1093/carcin/bgy046
Abstract: AFF4, an essential core of SEC, was overexpressed in HNSCC tissue and cell lines. AFF4 promoted the proliferation, migration, invasion and tumor-initiation capacity by regulating SOX2 in HNSCC cells, indicating AFF4 may serve as a… read more here.
Keywords: cell; tumor initiation; initiation capacity; regulating sox2 ... See more keywords
Abstract PR12: Paracrine orchestration of intestinal tumorigenesis at the mesenchymal-epithelial interface
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.hippo19-pr12
Abstract: Intestinal tumor initiation is a probabilistic process that depends on the competition between mutant and normal epithelial stem cells in crypts. Intestinal stem cells are closely associated with a diverse but poorly characterized network of… read more here.
Keywords: stem; stem cells; tumor initiation; tumorigenesis ... See more keywords
MAIT cells promote tumor initiation, growth and metastases via tumor MR1.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-19-0569
Abstract: Mucosal-associated invariant T (MAIT) cells are innate-like T cells that require MHC class I-related protein 1 (MR1) for their development. The role of MAIT cells in cancer is unclear and to date, no study has… read more here.
Keywords: growth; tumor initiation; mr1; tumor ... See more keywords
Glycolytic reprogramming through PCK2 regulates tumor initiation of prostate cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18787
Abstract: Tumor-initiating cells (TICs) play important roles in tumor progression and metastasis. Identifying the factors regulating TICs may open new avenues in cancer therapy. Here, we show that TIC-enriched prostate cancer cell clones use more glucose… read more here.
Keywords: cancer; pck2; tumor initiation; prostate cancer ... See more keywords
Cell Type-Specific Transcriptome Profiling Reveals a Role for Thioredoxin During Tumor Initiation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.818893
Abstract: Neutrophils in the tumor microenvironment exhibit altered functions. However, the changes in neutrophil behavior during tumor initiation remain unclear. Here we used Translating Ribosomal Affinity Purification (TRAP) and RNA sequencing to identify neutrophil, macrophage and… read more here.
Keywords: tumor; role thioredoxin; thioredoxin tumor; tumor initiation ... See more keywords