NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated TÂ cells.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109516
Abstract: Although tumor-infiltrating lymphocytes (TILs) maintain their ability to proliferate, persist, and eradicate tumors, they are frequently dysfunctional in situ. By performing both whole-genome CRISPR and metabolic inhibitor screens, we identify that nicotinamide phosphoribosyltransferase (NAMPT) is… read more here.
Keywords: tumor killing; tub; nad supplement; function ... See more keywords
PBRM1 and the glycosylphosphatidylinositol biosynthetic pathway promote tumor killing mediated by MHC-unrestricted cytotoxic lymphocytes
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abc3243
Abstract: This research uncovered regulators of tumor killing mediated by MHC-unrestricted cytotoxic lymphocytes. Major histocompatibility complex (MHC)–unrestricted cytotoxic lymphocytes (CLs) such as natural killer (NK) cells can detect and destroy tumor and virus-infected cells resistant to… read more here.
Keywords: tumor killing; unrestricted cytotoxic; cytotoxic lymphocytes; mhc unrestricted ... See more keywords
Neutrophil Conversion to a Tumor-Killing Phenotype Underpins Effective Microbial Therapy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/0008-5472.can-21-4025
Abstract: Intratumoral injection of microbial bioparticles stimulates neutrophil antitumor functions, suggesting pathways for optimizing efficacy of microbial therapies and paving the way for their broader utilization in the clinic. read more here.
Keywords: underpins effective; killing phenotype; phenotype underpins; conversion tumor ... See more keywords
Abstract 6377: A translatable tumor-killing platform with robust sensitivity towards immune checkpoint inhibitor targeted therapeutics
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6377
Abstract: The cancer treatment landscape has transformed following the clinical success of early immune checkpoint inhibitors (ICI) which demonstrate the remarkable power of harnessing the immune system to treat a variety of metastatic cancers. Despite the… read more here.
Keywords: cell; immune checkpoint; tumor killing; translatable tumor ... See more keywords
Molecular Characteristics of T Cell-Mediated Tumor Killing in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.868480
Abstract: Background Although checkpoint blockade is a promising approach for the treatment of hepatocellular carcinoma (HCC), subsets of patients expected to show a response have not been established. As T cell-mediated tumor killing (TTK) is the… read more here.
Keywords: mediated tumor; hepatocellular carcinoma; tumor killing; tumor ... See more keywords