Tumor Metabolism‐Engineered Composite Nanoplatforms Potentiate Sonodynamic Therapy via Reshaping Tumor Microenvironment and Facilitating Electron–Hole Pairs’ Separation
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202000326
Abstract: Reactive oxygen species (ROS) depletion and low ROS production that result from the intratumoral redox metabolism equilibrium and low energy conversion efficiency from ultrasound mechanical energy to ROS‐represented chemical energy, respectively, are two vital inhibitory… read more here.
Keywords: tumor; metabolism engineered; tumor metabolism; separation ... See more keywords
Bonded cumomer analysis of tumor metabolism based on 13C magnetic resonance spectroscopy
Sign Up to like & getrecommendations! Published in 2022 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4716
Abstract: Bonded cumomers are sets of isotopomers of 13C‐labeled metabolites containing a particular sequence of contiguously or singly labeled carbon atoms. Only these isotopomers contribute to multiplet structure in the 13C NMR spectrum. We discuss the… read more here.
Keywords: bonded cumomer; spectroscopy; tumor metabolism; analysis ... See more keywords
Autophagy and Tumor Metabolism.
Sign Up to like & getrecommendations! Published in 2017 at "Cell metabolism"
DOI: 10.1016/j.cmet.2017.04.004
Abstract: Autophagy is a critical cellular process that generally protects cells and organisms from stressors such as nutrient deprivation. In addition to its role in normal physiology, autophagy plays a role in pathological processes such as… read more here.
Keywords: metabolism; autophagy tumor; autophagy; tumor metabolism ... See more keywords
ZBTB7A links tumor metabolism to myeloid differentiation.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental hematology"
DOI: 10.1016/j.exphem.2020.05.010
Abstract: ZBTB7A is a transcription factor that regulates all three branches of hematopoietic differentiation while repressing the expression of key glycolytic enzymes and glucose transporters. Here, we propose that ZBTB7A acts as the link between differentiation… read more here.
Keywords: tumor metabolism; differentiation; links tumor; zbtb7a links ... See more keywords
Blocking EP4 downregulates tumor metabolism and synergizes with anti-PD-1 therapy to activate natural killer cells in a lung adenocarcinoma model.
Sign Up to like & getrecommendations! Published in 2022 at "International immunology"
DOI: 10.1093/intimm/dxac004
Abstract: Prostaglandin E2 (PGE2), a product of the cyclooxygenase (COX) pathway, is produced by tumors and surrounding stromal cells. It stimulates tumor progression, promotes angiogenesis, and suppresses the antitumor response. Pharmacological inhibition of PGE2 synthesis has… read more here.
Keywords: lung adenocarcinoma; natural killer; therapy; tumor metabolism ... See more keywords
The roles of IDH1 in tumor metabolism and immunity.
Sign Up to like & getrecommendations! Published in 2023 at "Future oncology"
DOI: 10.2217/fon-2022-0583
Abstract: IDH1 is a key metabolic enzyme for cellular respiration in the tricarboxylic acid (TCA) cycle that can convert isocitrate into α-ketoglutarate (α-KG) and generate NADPH. The reduction of IDH1 may affect dioxygenase activity and damage… read more here.
Keywords: roles idh1; immunity; tumor metabolism; idh1 tumor ... See more keywords
RPP25 as a Prognostic-Related Biomarker That Correlates With Tumor Metabolism in Glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.714904
Abstract: RPP25, a 25 kDa protein subunit of ribonuclease P (RNase P), is a protein-coding gene. Disorders associated with RPP25 include chromosome 15Q24 deletion syndrome and diffuse scleroderma, while systemic sclerosis can be complicated by malignancy.… read more here.
Keywords: glioblastoma; rpp25 expression; tumor metabolism; rpp25 ... See more keywords
The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives
Sign Up to like & getrecommendations! Published in 2020 at "Biomolecules"
DOI: 10.3390/biom10050791
Abstract: The NRF2/KEAP1 pathway is a fundamental signaling cascade that controls multiple cytoprotective responses through the induction of a complex transcriptional program that ultimately renders cancer cells resistant to oxidative, metabolic and therapeutic stress. Interestingly, accumulating… read more here.
Keywords: regulation tumor; keap1 axis; nrf2 keap1; tumor metabolism ... See more keywords
Integrative analysis of imaging and transcriptomic data of the immune landscape associated with tumor metabolism in lung adenocarcinoma: Clinical and prognostic implications
Sign Up to like & getrecommendations! Published in 2018 at "Theranostics"
DOI: 10.7150/thno.23767
Abstract: Although metabolic modulation in the tumor microenvironment (TME) is one of the key mechanisms of cancer immune escape, there is a lack of understanding of the comprehensive immune landscape of the TME and its association… read more here.
Keywords: immune; metabolism; tme; tumor metabolism ... See more keywords