BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020)
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DOI: 10.1002/advs.202070033
Abstract: Mitophagy is a selective autophagic process for clearing damaged mitochondria and maintaining a healthy mitochondrial network. In article number https://doi.org/10.1002/advs.201903616, Qiang Chen, Chu‐Xia Deng, and co‐workers demonstrate breast cancer susceptibility gene 1 (BRCA1) facilitates mitophagy… read more here.
Keywords: inflammasome activation; brca1; mammary tumor; tumor metastasis ... See more keywords
miR‐124‐3p availability is antagonized by LncRNA‐MALAT1 for Slug‐induced tumor metastasis in hepatocellular carcinoma
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DOI: 10.1002/cam4.2482
Abstract: As an oncogene, long noncoding RNA metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) can promote tumor metastasis. Hyperexpression of MALAT1 has been observed in many malignant tumors, including hepatocellular carcinoma (HCC). However, the role and mechanism… read more here.
Keywords: metastasis; tumor metastasis; hepatocellular carcinoma; mir 124 ... See more keywords
PRSS21/testisin inhibits ovarian tumor metastasis and antagonizes proangiogenic angiopoietins ANG2 and ANGPTL4
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-019-01763-3
Abstract: Ovarian cancer is the leading cause of death among all the gynecological cancers in the USA. Ovarian cancer employs a unique mode of metastasis, as exfoliated tumor cells disseminate within the peritoneal cavity, colonizing in… read more here.
Keywords: testisin; ovarian cancer; tumor metastasis; ovarian tumor ... See more keywords
Tumor-to-tumor metastasis of lung adenocarcinoma into a spinal intradural solitary fibrous tumor: a case report
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DOI: 10.1007/s00701-018-3700-z
Abstract: Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms commonly involving visceral or parietal pleura. We present the first report of tumor-to-tumor metastasis involving a pulmonary adenocarcinoma donor and an intradural SFT recipient. The patient presented… read more here.
Keywords: tumor; solitary fibrous; tumor tumor; tumor metastasis ... See more keywords
Natural killer cells and tumor metastasis
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DOI: 10.1007/s12272-017-0951-9
Abstract: Natural killer (NK) cells are cytotoxic lymphocytes that recognize tumor cells or stressed cells through ‘missing-self’ signals, such as altered or absent expression of MHC class I molecules. The function of NK cells is regulated… read more here.
Keywords: natural killer; metastasis; tumor metastasis; killer cells ... See more keywords
Identification of ACTG2 functions as a promoter gene in hepatocellular carcinoma cells migration and tumor metastasis.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.04.007
Abstract: Metastatic hepatocellular carcinoma (HCC) remains a mostly incurable disease. The fact that the identity of the mechanisms that regulate metastasis in HCC is known hampers the development of anti-metastatic therapies. Currently, there is no effective… read more here.
Keywords: hepatocellular carcinoma; hcc; cells migration; metastasis ... See more keywords
Mitochondrial chaperone, TRAP1 modulates mitochondrial dynamics and promotes tumor metastasis.
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DOI: 10.1016/j.mito.2020.08.001
Abstract: Mitochondria play a central role in regulating cellular energy metabolism. However, the present understanding of mitochondria has changed from its unipotent functions to pluripotent and insists on understanding the role of mitochondria not only in… read more here.
Keywords: mitochondrial chaperone; trap1 cells; metastasis; chaperone trap1 ... See more keywords
Nanomedicines inhibiting tumor metastasis and recurrence and their clinical applications
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DOI: 10.1016/j.nantod.2020.101004
Abstract: Abstract Tumor metastasis and recurrence is one of the biggest problems in curing cancers. Due to the difficulty in complete removal of the primary tumor in traditional surgeries and the poor drug delivery efficiency of… read more here.
Keywords: metastasis; clinical applications; metastasis recurrence; tumor metastasis ... See more keywords
Hippo kinases regulate cell junctions to inhibit tumor metastasis in response to oxidative stress
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DOI: 10.1016/j.redox.2019.101233
Abstract: Reactive oxygen species (ROS) are key regulators in cell proliferation, survival, tumor initiation and development. However, the role of ROS in tumor metastasis is less clear. Here, we show that oxidative stress inhibited tumor metastasis… read more here.
Keywords: tumor metastasis; cell; oxidative stress;
Tumor-Cell-Surface Adherable Peptide-Drug Conjugate Prodrug Nanoparticles Inhibit Tumor Metastasis and Augment Treatment Efficacy.
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DOI: 10.1021/acs.nanolett.0c00152
Abstract: Cancer metastasis is the main cause of chemotherapeutic failure. Inhibiting the activity of matrix metalloproteinases (MMPs) is a common strategy for reducing metastasis. However, broad-spectrum MMP-inhibitors (MMPI) may cause undesired side effects. Here, we screened… read more here.
Keywords: peptide drug; metastasis; inhibit tumor; drug conjugate ... See more keywords
Post-Remedial Oxygen Supply: A New Perspective on Photodynamic Therapy to Suppress Tumor Metastasis.
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DOI: 10.1021/acs.nanolett.2c02983
Abstract: Photodynamic therapy (PDT) holds great promise in tumor therapy due to high safety, efficacy, and specificity. However, the risk of increased metastasis in hypoxic tumors after oxygen-dependent PDT remains underestimated. Here, we propose a post-PDT… read more here.
Keywords: metastasis; therapy; tumor metastasis; oxygen ... See more keywords