Pan‐cancer analysis reveals sex‐specific signatures in the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13203
Abstract: The processes of cancer initiation, progression, and response to therapy are affected by the sex of cancer patients. Immunotherapy responses largely depend on the tumor microenvironment (TME), but how sex may shape some TME features, remains… read more here.
Keywords: sex specific; sex; cancer; tumor microenvironment ... See more keywords
Expression pattern of secretory‐cell‐related transcriptional signatures in colon adenocarcinomas defines tumor microenvironment characteristics and correlates with clinical outcomes
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DOI: 10.1002/1878-0261.13338
Abstract: Despite the connection of secretory cells to distinct mucus‐containing colon cancer histological subtypes and the interaction of secretory cells with immune cells in the pathogenesis of intestinal inflammatory diseases, whether the secretory cell signatures are… read more here.
Keywords: pattern secretory; secretory cell; tumor microenvironment; secretory ... See more keywords
Oxidative stress in the tumor microenvironment in gastric cancer and its potential role in immunotherapy.
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DOI: 10.1002/2211-5463.13630
Abstract: Gastric cancer (GC) is the fourth leading cause of cancer-related death and the fifth most common malignant tumor globally. However, the clinical efficacy of conventional therapies is limited. Currently, immunotherapy is considered an effective therapeutic… read more here.
Keywords: oxidative stress; cancer; tumor microenvironment; gastric cancer ... See more keywords
Reactive Oxygen Species–Activatable Liposomes Regulating Hypoxic Tumor Microenvironment for Synergistic Photo/Chemodynamic Therapies
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DOI: 10.1002/adfm.201905013
Abstract: Tumors have adapted various cellular antidotes and microenvironmental conditions to subsist against photodynamic therapy (PDT) and chemodynamic therapy (CDT). Here, the development of reactive oxygen species (ROS)‐activatable liposomes (RALP) for therapeutic enhancement by simultaneously addressing… read more here.
Keywords: tumor; tumor microenvironment; activatable liposomes; oxygen species ... See more keywords
Smart Tumor Microenvironment‐Responsive Nanotheranostic Agent for Effective Cancer Therapy
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DOI: 10.1002/adfm.202000486
Abstract: The tumor microenvironment (TME), which includes acidic and hypoxic conditions, severely impedes the therapeutic efficacy of antitumor agents. Herein, MnO2‐loaded, bovine serum albumin, and PEG co‐modified mesoporous CaSiO3 nanoparticles (CaM‐PB NPs) are developed as a… read more here.
Keywords: tumor; cancer; tumor microenvironment; effective cancer ... See more keywords
Recapitulating pancreatic tumor microenvironment through synergistic use of patient organoids and organ-on-a-chip vasculature.
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DOI: 10.1002/adfm.202000545
Abstract: Tumor progression relies heavily on the interaction between the neoplastic epithelial cells and their surrounding stromal partners. This cell cross-talk affects stromal development, and ultimately the heterogeneity impacts drug efflux and efficacy. To mimic this… read more here.
Keywords: pancreatic tumor; tumor microenvironment; organ chip; tumor ... See more keywords
Implantable Bioresponsive Nanoarray Enhances Postsurgical Immunotherapy by Activating Pyroptosis and Remodeling Tumor Microenvironment
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DOI: 10.1002/adfm.202005747
Abstract: Despite the potential of drug‐loaded scaffolds for tumor recurrence and metastasis (TRM) postoperation, their therapeutic benefits are limited by marked immunosuppressive tumor microenvironment (ITME) and drug‐related untargeted toxicity. Herein, an innovative implantable bioresponsive nanoarray is… read more here.
Keywords: tumor; tumor microenvironment; pyroptosis; nanoarray ... See more keywords
Self‐Assemblies of Fe3O4 Nanocrystals: Toward Nanoscale Precision of Photothermal Effects in the Tumor Microenvironment
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DOI: 10.1002/adfm.202006824
Abstract: Fe3O4 nanocrystals are self‐assembled into two different conformations: colloidosome and supraball that confer them with distinct properties determining their photo‐induced heating capacities. These self‐assemblies are assessed for photothermal therapy, an adjuvant strategy for tumor therapy.… read more here.
Keywords: tumor; fe3o4 nanocrystals; tumor microenvironment; self assemblies ... See more keywords
Functional CT Contrast Nanoagents for the Tumor Microenvironment.
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DOI: 10.1002/adhm.202000912
Abstract: Understanding the detailed tumor microenvironment (TME) is essential to achieve effective treatment of tumor, because TME has an extremely profound influence on the occurrence, development, invasion, and metastasis of tumor. It is of great significance… read more here.
Keywords: tme; tumor microenvironment; functional contrast; contrast nanoagents ... See more keywords
A Tumor Microenvironment Model of Pancreatic Cancer to Elucidate Responses toward Immunotherapy
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DOI: 10.1002/adhm.202201907
Abstract: Pancreatic cancer is a devastating malignancy with minimal treatment options. Standard‐of‐care therapy, including surgery and chemotherapy, is unsatisfactory, and therapies harnessing the immune system have been unsuccessful in clinical trials. Resistance to therapy and disease… read more here.
Keywords: pancreatic cancer; tumor microenvironment; responses toward; tumor ... See more keywords
Hyaluronan Receptors as Mediators and Modulators of the Tumor Microenvironment
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DOI: 10.1002/adhm.202202118
Abstract: The tumor microenvironment (TME) is a dynamic and complex matter shaped by heterogenous cancer and cancer‐associated cells present at the tumor site. Hyaluronan (HA) is a major TME component that plays pro‐tumorigenic and carcinogenic functions.… read more here.
Keywords: receptors mediators; tumor microenvironment; hyaluronan receptors; mediators modulators ... See more keywords