3D Bioprinted In Vitro Metastatic Models via Reconstruction of Tumor Microenvironments.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201806899
Abstract: The development of 3D in vitro models capable of recapitulating native tumor microenvironments could improve the translatability of potential anticancer drugs and treatments. Here, 3D bioprinting techniques are used to build tumor constructs via precise… read more here.
Keywords: vitro metastatic; bioprinted vitro; models via; tumor microenvironments ... See more keywords
A Tumor Microenvironments‐Adapted Polypeptide Hydrogel/Nanogel Composite Boosts Antitumor Molecularly Targeted Inhibition and Immunoactivation
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DOI: 10.1002/adma.202200449
Abstract: Various macro/microscopic biomaterials have been developed for controlled drug delivery in the combination therapy of malignancies. However, uncertain loading ratio, release sequence, and spatiotemporal distribution of drugs hinder their synergistic therapeutic effects and clinical applications.… read more here.
Keywords: hydrogel; microenvironments adapted; molecularly targeted; tumor microenvironments ... See more keywords
Fluorescence Lifetime Imaging for Quantification of Targeted Drug Delivery in Varying Tumor Microenvironments
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DOI: 10.1002/advs.202403253
Abstract: Trastuzumab (TZM) is a monoclonal antibody that targets the human epidermal growth factor receptor 2 (HER2) and is clinically used for the treatment of HER2‐positive breast tumors. However, the tumor microenvironment can limit the access… read more here.
Keywords: varying tumor; tzm her2; delivery; tumor microenvironments ... See more keywords
The multifaceted role of periostin in priming the tumor microenvironments for tumor progression
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DOI: 10.1007/s00018-017-2646-2
Abstract: Tumor microenvironment consists of tumor cells, stromal cells, extracellular matrix and a plethora of soluble components. The complex array of interactions between tumor cells and their surrounding tumor microenvironments contribute to the determination of the… read more here.
Keywords: role periostin; multifaceted role; tumor microenvironments; tumor ... See more keywords
Photodynamic creation of artificial tumor microenvironments to collectively facilitate hypoxia-activated chemotherapy delivered by coagulation-targeting liposomes
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2021.128731
Abstract: Abstract Creation of artificial tumor microenvironments is promising to avoid tumor heterogeneity induced variation of cancer therapeutic efficacy. Herein, a type of cooperative liposomal delivery systems based on photodynamic liposomes and coagulation-targeting liposomes is proposed… read more here.
Keywords: tumor microenvironments; coagulation; coagulation targeting; tumor ... See more keywords
SpatialSNV: A novel method for identifying and analyzing spatially resolved SNVs in tumor microenvironments
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DOI: 10.1093/gigascience/giaf065
Abstract: Abstract Background The dynamics of single-nucleotide variants (SNVs) play a critical role in understanding tumor development, yet their influence on shaping tumor microenvironments remains largely unexplored. Spatial transcriptomics offers an opportunity to map SNVs within… read more here.
Keywords: spatial transcriptomics; snvs; novel method; tumor microenvironments ... See more keywords
Metabolic adaptations of cancer in extreme tumor microenvironments
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DOI: 10.1111/cas.15722
Abstract: Cancer cells are highly heterogeneous to adapt to extreme tumor microenvironments (TMEs). TMEs challenge cancer cells via hypoxia, nutrition starvation, and acidic pH, promoting invasion and metastasis concomitant with genetic, epigenetic, and metabolic alterations. Metabolic… read more here.
Keywords: cell; cancer; extreme tumor; tumor microenvironments ... See more keywords
Abstract 1782: Functional potency assay predicts CAR-T effectiveness in tumor microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1782
Abstract: Chimeric antigen receptor (CAR) T cell therapy holds great promise for the treatment of various cancers, including solid tumors. However, attempts to model the behavior and effectiveness of CAR-T cell therapies for blood cancers and… read more here.
Keywords: cell; potency; car; effectiveness ... See more keywords
Abstract PO010: Engineering T cells to enhance 3D migration through mechanically and structurally complex tumor microenvironments
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DOI: 10.1158/1538-7445.tme21-po010
Abstract: While chemical signals play a strong role in drawing T cells into solid tumors, the physical features of the stroma, such as architecture and mechanics, also strongly influence T cell infiltration as well as their… read more here.
Keywords: complex tumor; tumor microenvironments; engineering; tumor ... See more keywords
Acidic Tumor Microenvironments and Emerging Therapeutic Strategies for Cancer Therapy
Sign Up to like & getrecommendations! Published in 2025 at "Yonsei Medical Journal"
DOI: 10.3349/ymj.2024.0210
Abstract: Hypoxia and acidity represent two distinct properties of tumor microenvironments (TMEs). Tumor acidity was initially proposed to be a “by-product” of hypoxia, which results from abnormal vasculature and excessive oxygen demands. It is now recognized… read more here.
Keywords: cancer; tumor microenvironments; acidic tmes; acidity ... See more keywords
Links Between N 6-Methyladenosine and Tumor Microenvironments in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.807129
Abstract: N 6-methyladenosine (m6A) is a critical epigenetic modification for tumor malignancies, but its role in regulating the tumor microenvironments (TMEs) has not been fully studied. By integrating multiple data sets and multi-omics data, we comprehensively… read more here.
Keywords: tumor; cancer; links methyladenosine; m6a ... See more keywords