Application of Artificial Intelligence to In Vitro Tumor Modeling and Characterization of the Tumor Microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202457
Abstract: In vitro tumor models have played vital roles in enhancing the understanding of the cellular and molecular composition of tumors, as well as their biochemical and biophysical characteristics. Advances in technology have enabled the evolution… read more here.
Keywords: vitro tumor; tumor modeling; tumor models; tumor microenvironment ... See more keywords
Co‐culturing multicellular tumor models: Modeling the tumor microenvironment and analysis techniques
Sign Up to like & getrecommendations! Published in 2021 at "PROTEOMICS"
DOI: 10.1002/pmic.202000103
Abstract: Advances in two‐dimensional (2D) and three‐dimensional (3D) cell culture over the last 10 years have led to the development of a plethora of methods for cultivating tumor models. More recently, cellular co‐cultures have become a… read more here.
Keywords: tumor models; analysis; culturing multicellular; multicellular tumor ... See more keywords
In Vitro and In Vivo Tumor Models for the Evaluation of Anticancer Nanoparticles.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-58174-9_12
Abstract: Multiple studies about tumor biology have revealed the determinant role of the tumor microenvironment in cancer progression, resulting from the dynamic interactions between tumor cells and surrounding stromal cells within the extracellular matrix. This malignant… read more here.
Keywords: anticancer nanoparticles; vivo tumor; tumor models; vitro vivo ... See more keywords
Cell sheet-based multilayered liver tumor models for anti-cancer drug screening
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Letters"
DOI: 10.1007/s10529-017-2476-1
Abstract: ObjectiveTo fabricate in vitro cell-dense, three-dimensional (3D) tumor models by employing a cell sheet technology for testing anti-cancer drug efficacy.ResultsThe stratified liver tumor models were fabricated by stacking contiguous HepG2 cell sheets. Triple-layer (3L), double-layer… read more here.
Keywords: cell sheet; cell; liver tumor; tumor models ... See more keywords
Engineered In Vitro Tumor Models for Cell-Based Immunotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.03.076
Abstract: Tumor immunotherapy is rapidly evolving as one of the major pillars of cancer treatment. Cell-based immunotherapies, which utilize patient's own immune cells to eliminate cancer cells, have shown great promise in treating a range of… read more here.
Keywords: immunotherapy; tumor models; cell based; based immunotherapies ... See more keywords
Bioengineered tissue models for the development of dynamic immuno-associated tumor models and high-throughput immunotherapy cytotoxicity assays.
Sign Up to like & getrecommendations! Published in 2020 at "Drug discovery today"
DOI: 10.1016/j.drudis.2020.11.028
Abstract: Cancer immunotherapy is rapidly developing, with numerous therapies approved over the past decade and more therapies expected to gain approval in the future. However, immunotherapy of solid tumors has been less successful because immunosuppressive barriers… read more here.
Keywords: mediated tumor; immunotherapy; tumor models; cancer ... See more keywords
Chorioallantoic membrane tumor models highlight the effects of cisplatin compounds in oral carcinoma treatment
Sign Up to like & getrecommendations! Published in 2022 at "iScience"
DOI: 10.1016/j.isci.2022.103980
Abstract: Summary The European Society for Medical Oncology (ESMO) suggests the use of chemotherapy as neoadjuvant, adjuvant, and concomitant to surgery and radiotherapy for the treatment of oral carcinoma by depending on the cancer stage. The… read more here.
Keywords: tumor; chorioallantoic membrane; treatment; tumor models ... See more keywords
Untargeted 2D NMR Metabolomics of [13C-methyl]Methionine-Labeled Tumor Models Reveals the Non-DNA Methylome and Provides Clues to Methyl Metabolism Shift during Tumor Progression.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00778
Abstract: For more than a decade, DNA and histone methylations have been the focus of extensive work, although their relationship with methyl group metabolism was overlooked. Recently, it has emerged that epigenetic methylations are influenced by… read more here.
Keywords: tumor; metabolism; nmr metabolomics; methionine ... See more keywords
Quantitative Imaging of Hypoxic CAIX-Positive Tumor Areas with Low Immune Cell Infiltration in Syngeneic Mouse Tumor Models
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00045
Abstract: Limited diffusion of oxygen in combination with increased oxygen consumption leads to chronic hypoxia in most solid malignancies. This scarcity of oxygen is known to induce radioresistance and leads to an immunosuppressive microenvironment. Carbonic anhydrase… read more here.
Keywords: syngeneic mouse; tumor models; caix; hypoxic ... See more keywords
Divergent evolutionary trajectories in transplanted tumor models
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3983
Abstract: Human-derived tumor models are becoming popular in the context of personalized medicine, but a new study shows that these models could be less representative of primary tumors than previously thought, particularly when using late passages. read more here.
Keywords: trajectories transplanted; tumor models; evolutionary trajectories; transplanted tumor ... See more keywords
A biobank of patient-derived pediatric brain tumor models
Sign Up to like & getrecommendations! Published in 2018 at "Nature Medicine"
DOI: 10.1038/s41591-018-0207-3
Abstract: Brain tumors are the leading cause of cancer-related death in children. Genomic studies have provided insights into molecular subgroups and oncogenic drivers of pediatric brain tumors that may lead to novel therapeutic strategies. To evaluate… read more here.
Keywords: tumor models; brain tumor; pediatric brain; brain ... See more keywords