Smoking status combined with tumor mutational burden as a prognosis predictor for combination immune checkpoint inhibitor therapy in non‐small cell lung cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.4197
Abstract: This study aimed to explore the prognostic value of tumor mutational burden (TMB) combined with smoking status in advanced non‐small cell lung cancer (NSCLC) patients who received immune checkpoint inhibitor therapy (anti PD‐1/PD‐L1 therapy) combined… read more here.
Keywords: tumor mutational; smoking status; cancer; non small ... See more keywords
Prognostic attributes of immune signatures in soft tissue sarcomas show differential dependencies on tumor mutational burden
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DOI: 10.1002/cncr.34333
Abstract: Cellular and intrinsic markers of sarcoma immunogenicity are poorly understood. To gain insight into whether tumor–immune interactions correlate with clinical aggressiveness, the authors examined the prognostic significance of immune gene signatures in combination with tumor… read more here.
Keywords: attributes immune; immune signatures; tumor mutational; prognostic attributes ... See more keywords
Prognostic impact of copy number alterations and tumor mutational burden in carcinoma of unknown primary
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DOI: 10.1002/gcc.23047
Abstract: Chromosomal aberrations are known to drive metastatic spread, but their profile is still elusive in carcinoma of unknown primary (CUP). Therefore, the aim of this study was to characterize the chromosomal aberration pattern in CUP… read more here.
Keywords: prognostic impact; unknown primary; tumor mutational; mutational burden ... See more keywords
Tumor mutational burden and immune infiltrates in renal cell carcinoma and matched brain metastases
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DOI: 10.1016/j.esmoop.2021.100057
Abstract: Background Tumor mutational burden (TMB) and density of tumor-infiltrating lymphocytes (TIL) have been postulated as predictive biomarkers for immunotherapy. Therefore, we investigated the concordance of TMB and TIL of primary/extracranial renal cell carcinoma (RCC) specimens… read more here.
Keywords: renal cell; tumor mutational; cell carcinoma; brain ... See more keywords
Germline variants predictive of tumor mutational burden and immune checkpoint inhibitor efficacy
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DOI: 10.1016/j.isci.2021.102248
Abstract: Summary High tumor mutational burden (TMB) is associated with response to checkpoint blockade in several cancers. We identify pathogenic germline variants associated with increased TMB (GVITMB). GVITMB were found in 7 genes using a pan-cancer… read more here.
Keywords: immune checkpoint; tumor mutational; germline variants; checkpoint ... See more keywords
Hot or Not: Tumor Mutational Burden (TMB) as a Biomarker of Immunotherapy Response in Genitourinary Cancers.
Sign Up to like & getrecommendations! Published in 2020 at "Urology"
DOI: 10.1016/j.urology.2020.10.030
Abstract: Pembrolizumab was recently approved for treatment of cancers with high tumor mutational burden (TMB). We conduct a focused literature review of TMB as a predictive biomarker. TMB quantifies the sum of non-synonymous coding mutations (typically… read more here.
Keywords: tumor mutational; biomarker; genitourinary cancers; tmb ... See more keywords
The association between tumor mutational burden and prognosis is dependent on treatment context
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DOI: 10.1038/s41588-020-00752-4
Abstract: In multiple cancer types, high tumor mutational burden (TMB) is associated with longer survival after treatment with immune checkpoint inhibitors (ICIs). The association of TMB with survival outside of the immunotherapy context is poorly understood.… read more here.
Keywords: tumor mutational; treatment; tmb associated; mutational burden ... See more keywords
MiRNA expression patterns are associated with tumor mutational burden in lung adenocarcinoma
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DOI: 10.1080/2162402x.2019.1629260
Abstract: ABSTRACT Background: Tumor mutational burden (TMB) has emerged as an independent biomarker to predict patient responses to treatment with immune checkpoint inhibitors (ICIs) for lung adenocarcinoma (LUAD). MicroRNAs (miRNAs) have a crucial role in the… read more here.
Keywords: expression; mirna based; signature classifier; tumor mutational ... See more keywords
Tumor mutational burden measurement using comprehensive genomic profiling assay.
Sign Up to like & getrecommendations! Published in 2022 at "Japanese journal of clinical oncology"
DOI: 10.1093/jjco/hyac063
Abstract: BACKGROUND Tumors with a high number of mutations in the genome, or tumor mutational burden, are presumed to be more likely to respond to immune checkpoint inhibitors. However, the optimal method to calculate tumor mutational… read more here.
Keywords: mutational burden; tumor mutational; deoxyribonucleic acid; todai oncopanel ... See more keywords
Tumor mutational burden and somatic mutation status to predict disease recurrence in advanced melanoma
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DOI: 10.1097/cmr.0000000000000808
Abstract: Tumor mutational burden (TMB) has recently been identified as a biomarker of response to immune checkpoint inhibitors in many cancers, including melanoma. Co-assessment of TMB with inflammatory markers and genetic mutations may better predict disease… read more here.
Keywords: tumor mutational; disease; advanced melanoma; recurrence ... See more keywords
Characterization of tumors with ultralow tumor mutational burden in Japanese cancer patients
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DOI: 10.1111/cas.14572
Abstract: Tumor mutational burden analysis using whole‐exome sequencing highlights features of tumors with various mutations or known driver alterations. Cancers with few changes in the exon regions have unclear characteristics, even though low‐mutated tumors are often… read more here.
Keywords: tumor mutational; ultralow tumor; cancer; mutational burden ... See more keywords