Predicting Probability of Response to Tumor Necrosis Factor Inhibitors for Individual Patients With Ankylosing Spondylitis
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.2312
Abstract: Key Points Question Is it possible to predict short-term treatment response to tumor necrosis factor inhibitors (TNFis) accurately in patients with active ankylosing spondylitis (AS)? Findings In a cohort study of individual participant data from… read more here.
Keywords: necrosis factor; response tumor; tumor necrosis; factor inhibitors ... See more keywords
Comparative Outcomes and Safety of Vedolizumab vs Tumor Necrosis Factor Antagonists for Older Adults With Inflammatory Bowel Diseases
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DOI: 10.1001/jamanetworkopen.2022.34200
Abstract: Key Points Question What is the comparative effectiveness and safety of vedolizumab vs tumor necrosis factor (TNF) antagonists for older patients with inflammatory bowel diseases (IBDs)? Findings In a comparative effectiveness study of 754 older… read more here.
Keywords: necrosis factor; safety; vedolizumab tumor; tumor necrosis ... See more keywords
Insurance Delays in Initiation of Tumor Necrosis Factor Inhibitors in Children With Juvenile Idiopathic Arthritis
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.8330
Abstract: This cohort study compares the delays in tumor necrosis factor inhibitor (TNFi) initiation because of insurance among children enrolled in public and private insurance plans. read more here.
Keywords: tumor necrosis; insurance; necrosis factor;
Antidrug Antibodies to Tumor Necrosis Factor α Inhibitors in Patients With Noninfectious Uveitis.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2022.5584
Abstract: Importance Tumor necrosis factor inhibitors (TNFis) can induce antidrug antibody (ADA) formation and loss of therapeutic response. However, the utility of ADA testing and the association between ADAs and treatment response in patients with noninfectious… read more here.
Keywords: mean drug; level; tumor necrosis; drug ... See more keywords
Structural modeling of tumor necrosis factor: A protein of immunological importance
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1523
Abstract: Tumor necrosis factor (TNF) is a multifunctional pro‐inflammatory cytokine responsible for various immunoregulatory activities. Upon binding with its receptor, TNF triggers multiple complex signaling pathways such as the activations of nuclear factor kappa B and… read more here.
Keywords: factor; structural modeling; necrosis factor; tumor necrosis ... See more keywords
Mechanisms underlying synergism between circularized tumor necrosis factor‐related apoptosis inducing ligand and bortezomib in bortezomib‐sensitive or ‐resistant myeloma cells
Sign Up to like & getrecommendations! Published in 2022 at "Hematological Oncology"
DOI: 10.1002/hon.3045
Abstract: Mechanisms underlying interactions between a novel, clinically relevant circularized tumor necrosis factor‐related apoptosis inducing ligand (TRAIL) agonist, circularly permuted TRAIL (CPT) have been examined in multiple myeloma (MM) cells sensitive or resistant to bortezomib (BTZ).… read more here.
Keywords: necrosis factor; bortezomib; apoptosis; tumor necrosis ... See more keywords
Tissue influx of neutrophils and monocytes is delayed during development of trovafloxacin‐induced tumor necrosis factor‐dependent liver injury in mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3585
Abstract: Idiosyncratic drug‐induced liver injury (iDILI) has a poorly understood pathogenesis. However, iDILI is often associated with inflammatory stress signals in human patients as well as animal models. Tumor necrosis factor (TNF) and neutrophils play a… read more here.
Keywords: tvx; treated mice; tumor necrosis; liver injury ... See more keywords
Tumor Necrosis Factor‐α Induced Apoptosis in U937 Cells Promotes Cathepsin D‐Independent Stefin B Degradation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26152
Abstract: Lysosomal cathepsins were previously found to be involved in tumor necrosis factor‐α (TNFα)‐induced apoptosis. However, there are opposing views regarding their role as either initiators or amplifiers of the signaling cascade as well as the… read more here.
Keywords: degradation; apoptosis u937; apoptosis; induced apoptosis ... See more keywords
Tumor necrosis factor‐alpha stimulated gene‐6: A biomarker reflecting disease activity in rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24395
Abstract: To explore the serum tumor necrosis factor‐alpha stimulated gene‐6 (TSG‐6) level and its association with disease activity in rheumatoid arthritis (RA) patients. read more here.
Keywords: necrosis factor; alpha stimulated; disease activity; tumor necrosis ... See more keywords
Association of tumor necrosis factor alpha ‐308 single nucleotide polymorphism with SARS CoV‐2 infection in an Iraqi Kurdish population
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24400
Abstract: Uncovering risk factors playing roles in the severity of Coronavirus disease 2019 (Covid‐19) are important for understanding pathoimmunology of the disease caused by severe acute respiratory syndrome Coronavirus 2 (SARS CoV‐2). Genetic variations in innate… read more here.
Keywords: nucleotide polymorphism; polymorphism; single nucleotide; tumor necrosis ... See more keywords
Examining the potential direct cardiovascular benefit of tumor‐necrosis factor inhibitor in rheumatoid arthritis: Natural and controlled direct effect analyses
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.5546
Abstract: Tumor necrosis factor inhibitors (TNFi) may have a direct benefit on cardiovascular (CV) disease beyond reducing rheumatoid arthritis (RA) disease activity measured by the Clinical Disease Activity Index (CDAI). read more here.
Keywords: tumor necrosis; necrosis factor; rheumatoid arthritis;