An ATLAS to find tumor neoantigens
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.371.6533.1005-e
Abstract: Cancer Tumor neoantigens are cancer-specific antigens that are not found in healthy cells and play a major role in anticancer immune responses. Immunotherapies such as cancer vaccines can be based on known neoantigens, but it… read more here.
Keywords: atlas find; cancer; tumor neoantigens; tumor ... See more keywords
Abstract 5647: Intron retention as a novel source of tumor neoantigens associated with response to checkpoint inhibitor therapy
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-5647
Abstract: Background: Development of immune checkpoint inhibitors has substantially improved outcomes in patients diagnosed with metastatic melanoma. However, only a minority of patients treated experience long-term clinical benefit, and clinicians have limited ability to predict which… read more here.
Keywords: clinical benefit; tumor neoantigens; response; checkpoint ... See more keywords
Abstract B82: Identification of tumor neoantigens for combination therapy in murine tumor models
Sign Up to like & getrecommendations! Published in 2018 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm17-b82
Abstract: The adoption of anti-CTLA-4 and anti-PD-1/PD-L1 blockade has dramatically changed the treatment approaches in multiple cancer types, and has demonstrated the power of the immune system to control the outgrowth of neoplastic lesions. Accumulating evidence… read more here.
Keywords: combination; nonsynonymous mutations; tumor neoantigens; therapy ... See more keywords