Discrimination of tumor from normal tissues in a mouse model of breast cancer using CARS spectroscopy combined with PC‐DFA methodology
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Raman Spectroscopy"
DOI: 10.1002/jrs.5201
Abstract: Objective methodologies to discriminate tumor from normal tissue in biopsies and resection specimens are of great interest as complementary approaches to existing pathological diagnosis of tumors. In the present study, coherent anti-Stokes Raman scattering (CARS)… read more here.
Keywords: methodology; tumor normal; spectroscopy; breast cancer ... See more keywords
A comprehensive quality control workflow for paired tumor‐normal NGS experiments
Sign Up to like & getrecommendations! Published in 2017 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btx032
Abstract: Summary: Quality control (QC) is an important part of all NGS data analysis stages. Many available tools calculate QC metrics from different analysis steps of single sample experiments (raw reads, mapped reads and variant lists).… read more here.
Keywords: quality control; normal pairs; tumor normal; tumor ... See more keywords
Abstract A190: Management of germline findings revealed throughout the course of tumor-normal whole genome sequencing in oncology
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-a190
Abstract: Background: The Personalized OncoGenomics (POG) project at the BC Cancer Agency utilizes tumor-normal whole genome sequencing (WGS) to understand key driver pathways and guide personalized treatment decisions. Analysis of the germline data can reveal variants;… read more here.
Keywords: whole genome; tumor normal; normal whole; cancer ... See more keywords
Abstract 876: Sequencing a new broadly-consented tumor/normal cell line for a Genome in a Bottle Benchmark
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-876
Abstract: Here, we describe analyses towards the first tumor/normal benchmark from the Genome in a Bottle (GIAB) consortium using new cell lines from a broadly-consented pancreatic ductal adenocarcinoma patient. This effort builds on the widely-used germline… read more here.
Keywords: tumor normal; broadly consented; genome bottle; tumor ... See more keywords
Modeling and correct the GC bias of tumor and normal WGS data for SCNA based tumor subclonal population inferring
Sign Up to like & getrecommendations! Published in 2018 at "BMC Bioinformatics"
DOI: 10.1186/s12859-018-2099-0
Abstract: BackgroundSomatic copy number alternations (SCNAs) can be utilized to infer tumor subclonal populations in whole genome seuqncing studies, where usually their read count ratios between tumor-normal paired samples serve as the inferring proxy. Existing SCNA… read more here.
Keywords: tumor subclonal; tumor normal; scna based; subclonal population ... See more keywords
Tumor/normal genomic profiling in patients with metastatic solid tumors identifies pathogenic germline variants of therapeutic importance.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.1501
Abstract: 1501Background: Tumor molecular profiling via next-generation sequencing (NGS) is routinely utilized to direct patients toward clinical trials of targeted therapeutics. NGS testing of paired tumor/... read more here.
Keywords: profiling; normal genomic; tumor normal; genomic profiling ... See more keywords
Rare Tumor-Normal Matched Whole Exome Sequencing Identifies Novel Genomic Pathogenic Germline and Somatic Aberrations
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12061618
Abstract: Whole exome sequencing (WES) of matched tumor-normal pairs in rare tumors has the potential to identify genome-wide mutations and copy number alterations (CNAs). We evaluated 27 rare cancer patients with tumor-normal matching by WES and… read more here.
Keywords: exome sequencing; germline somatic; tumor normal; whole exome ... See more keywords