Abstract IA09: Tumor organoid cultures as a platform for functional genomics
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.camodels2020-ia09
Abstract: In an era of genomics-guided precision medicine, there is an increasing need for models that reflect the hallmarks of cancer and the molecular diversity of patient tumors. New cell culturing methods are transforming our ability… read more here.
Keywords: cultures platform; tumor organoid; functional genomics; organoid cultures ... See more keywords
Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes
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DOI: 10.15252/emmm.202216001
Abstract: Rhabdomyosarcomas (RMS) are mesenchyme-derived tumors and the most common childhood soft tissue sarcomas. Treatment is intense, with a nevertheless poor prognosis for high-risk patients. Discovery of new therapies would benefit from additional preclinical models. Here… read more here.
Keywords: organoid models; models recapitulate; recapitulate rhabdomyosarcoma; tumor organoid ... See more keywords
Genomic and Epigenomic Characterization of Tumor Organoid Models
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DOI: 10.3390/cancers14174090
Abstract: Simple Summary The patient-derived organoid (PDO) model is a versatile and dynamic tool for investigating individual genomic and epigenomic properties of cancer. PDOs preserve key (epi-)genomic features and maintain physiological and pathological characteristics, resembling patient… read more here.
Keywords: oncology; genomic epigenomic; organoid modeling; tumor organoid ... See more keywords