MALDI Mass Spectrometry Imaging for Evaluation of Therapeutics in Colorectal Tumor Organoids
Sign Up to like & getrecommendations! Published in 2017 at "Journal of The American Society for Mass Spectrometry"
DOI: 10.1007/s13361-017-1851-4
Abstract: AbstractPatient-derived colorectal tumor organoids (CTOs) closely recapitulate the complex morphological, phenotypic, and genetic features observed in in vivo tumors. Therefore, evaluation of drug distribution and metabolism in this model system can provide valuable information to… read more here.
Keywords: drug; tumor organoids; colorectal tumor; mass spectrometry ... See more keywords
Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.07.009
Abstract: Cancer immunotherapies have shown substantial clinical activity for a subset of patients with epithelial cancers. Still, technological platforms to study cancer T-cell interactions for individual patients and understand determinants of responsiveness are presently lacking. Here,… read more here.
Keywords: tumor; tumor organoids; reactive cells; peripheral blood ... See more keywords
Manipulating the Tumor Microenvironment in Tumor Organoids Induces Phenotypic Changes and Chemoresistance
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DOI: 10.1016/j.isci.2020.101851
Abstract: Summary Tumors comprised a tightly surrounded tumor microenvironment, made up of non-cellular extracellular matrix (ECM) and stromal cells. Although treatment response is often attributed to tumor heterogeneity, progression and malignancy are profoundly influenced by tumor… read more here.
Keywords: cell; tumor organoids; tumor cell; ecm ... See more keywords
Use of inkjet-printed single cells to quantify intratumoral heterogeneity.
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DOI: 10.1088/1758-5090/ab9491
Abstract: Quantification of intratumoural heterogeneity is essential for designing effective therapeutic strategies in the age of personalized medicine. In this study, we used a piezoelectric inkjet printer to enable analysis of intratumoral heterogeneity in a bladder… read more here.
Keywords: inkjet printed; heterogeneity; tumor organoids; intratumoral heterogeneity ... See more keywords
Rapid drug screen using 3D tumor organoids
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aar7507
Abstract: Breast cancer organoids enable high-throughput functional drug screens to potentially guide individualized therapy. Breast cancer organoids enable high-throughput functional drug screens to potentially guide individualized therapy. read more here.
Keywords: screen using; rapid drug; tumor organoids; drug ... See more keywords
Abstract 992: Patient-derived tumor organoids of neuroendocrine prostate cancer
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DOI: 10.1158/1538-7445.am2017-992
Abstract: Background: The development of neuroendocrine prostate cancer (NEPC) is one mechanism of treatment resistance to androgen receptor (AR)-targeted therapies for a subset of patients with advanced prostate cancer. This is associated with transition from a… read more here.
Keywords: tumor organoids; prostate cancer; cancer; patient derived ... See more keywords
Abstract 6652: Employingex vivo3D-Screen technology for the development of rational combinations of immuno-oncology drugs in tumor organoids of fresh patient tissue
Sign Up to like & getrecommendations! Published in 2020 at "Immunology"
DOI: 10.1158/1538-7445.am2020-6652
Abstract: Introduction: Modern evaluation of novel immuno-oncological drug combinations requires a multi-faceted approach to accurately determine immune-cell activation and tumor cell viability. Additionally, retention of the intact tumor microenvironment through preparation of 3D tumor organoids is… read more here.
Keywords: tumor organoids; tumor cell; fresh patient; oncology ... See more keywords
Abstract 1069: A novel PAThway based RNA and DNA Integration with Tumor Organoid Testing (PATRIOTTM) platform predicts therapeutic options in cohorts with MET overexpression and CDKN2A downregulation in patients with colon and pancreatic cancers
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1069
Abstract: Background: Cancer therapy has witnessed great progress over the last 50 years with advancements in diagnostic tools to enable more precise treatment. With the development of next-generation sequencing, the field of precision oncology has been… read more here.
Keywords: platform; met overexpression; downregulation; tumor ... See more keywords
Appendiceal Cancer Patient-Specific Tumor Organoid Model for Predicting Chemotherapy Efficacy Prior to Initiation of Treatment: A Feasibility Study
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Surgical Oncology"
DOI: 10.1245/s10434-018-7008-2
Abstract: IntroductionWe have hypothesized that biofabrication of appendiceal tumor organoids allows for a more personalized clinical approach and facilitates research in a rare disease.MethodsAppendiceal cancer specimens obtained during cytoreduction with hyperthermic intraperitoneal chemotherapy procedures (CRS/HIPEC) were… read more here.
Keywords: tumor; patient specific; tumor organoids; cancer ... See more keywords