Reduced sister chromatid cohesion acts as a tumor penetrance modifier
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DOI: 10.1371/journal.pgen.1010341
Abstract: Sister chromatid cohesion (SCC) is an important process in chromosome segregation. ESCO2 is essential for establishment of SCC and is often deleted/altered in human cancers. We demonstrate that esco2 haploinsufficiency results in reduced SCC and… read more here.
Keywords: tumor penetrance; chromatid cohesion; sister chromatid;