Isolation of Primary Hepatocytes for Testing Tumor Penetrating Peptides.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1752-6_26
Abstract: Methods for isolation of human primary cells is an important tool to be able to test the effect of several drugs for the treatment of diseases. Protocols have been described for the isolation of healthy… read more here.
Keywords: primary hepatocytes; penetrating peptides; tumor penetrating; isolation primary ... See more keywords
Sensitizing Tumors to Immune Checkpoint Blockage via STING Agonists Delivered by Tumor-Penetrating Neutrophil Cytopharmaceuticals.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c11764
Abstract: Immune checkpoint inhibitors (ICIs) have displayed potential efficacy in triple-negative breast cancer (TNBC) treatment, while only a minority of patients benefit from ICI therapy currently. Although activation of the innate immune stimulator of interferon genes… read more here.
Keywords: immune checkpoint; neutrophil cytopharmaceuticals; sting agonists; tumor ... See more keywords
Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13032-9
Abstract: Vestibular schwannoma (VS) is the most common tumor of the cerebellopontine angle, and it typically presents with sensorineural hearing loss. The genomic landscape of schwannoma is complex and many of the molecules implicated in VS… read more here.
Keywords: tnf; delivery sirna; delivery; tumor penetrating ... See more keywords
Tumor‐penetrating peptide internalizing RGD enhances radiotherapy efficacy through reducing tumor hypoxia
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15295
Abstract: Resistance to irradiation (IR) remains a major therapeutic challenge in tumor radiotherapy. The development of novel tumor‐specific radiosensitizers is crucial for effective radiotherapy against solid tumors. Here, we revealed that remodeling tumor tissue penetration via… read more here.
Keywords: rgd; peptide internalizing; efficacy; penetrating peptide ... See more keywords
Abstract 5088: Tumor penetrating RNA delivery for therapeutic benefit of pancreatic cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-5088
Abstract: Pancreatic cancer remains a deadly disease with a median survival of less than one year, in part because we lack effective therapeutic strategies. Mutations of the oncogene KRAS and the tumor suppressor genes TP53, INK4A,… read more here.
Keywords: delivery; pancreatic cancer; tumor penetrating; therapeutic benefit ... See more keywords
Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Investigation"
DOI: 10.1172/jci92284
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is almost uniformly fatal; however, some improvement in overall survival has been achieved with the introduction of nanocarriers that deliver irinotecan or paclitaxel. Although it is generally assumed that nanocarriers rely… read more here.
Keywords: silicasome based; penetrating peptide; tumor penetrating; cancer ... See more keywords
Tumor penetrating peptide-functionalized Tenascin-C antibody for glioblastoma targeting.
Sign Up to like & getrecommendations! Published in 2020 at "Current cancer drug targets"
DOI: 10.2174/1568009620666201001112749
Abstract: BACKGROUND Conjugation to clinical-grade tumor penetrating iRGD peptide is a widely used strategy to improve tumor homing, extravasation, and penetration of cancer drugs and tumor imaging agents. The C domain of extracellular matrix molecule Tenascin-C… read more here.
Keywords: irgd; antibody; tumor penetrating; scfv g11 ... See more keywords
In Silico and In Vivo Studies of a Tumor-Penetrating and Interfering Peptide with Antitumoral Effect on Xenograft Models of Breast Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15041180
Abstract: The combination of a tumor-penetrating peptide (TPP) with a peptide able to interfere with a given protein–protein interaction (IP) is a promising strategy with potential clinical application. Little is known about the impact of fusing… read more here.
Keywords: effect; breast cancer; tpp; silico vivo ... See more keywords
[Corrigendum] Tumor‑penetrating peptide fused EGFR single‑domain antibody enhances radiation responses following EGFR inhibition in gastric cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Oncology reports"
DOI: 10.3892/or.2020.7834
Abstract: Following the publication of the above article, the authors noticed that data shown in certain of the panels in Figs. 4 and 5 were selected incorrectly and presented wrongly in these figures. Essentially, in Fig. 4, the data… read more here.
Keywords: corrigendum; penetrating peptide; tumor penetrating; corrigendum tumor ... See more keywords
Tumor-penetrating Peptide Conjugated and Doxorubicin Loaded T1-T2 Dual Mode MRI Contrast Agents Nanoparticles for Tumor Theranostics
Sign Up to like & getrecommendations! Published in 2018 at "Theranostics"
DOI: 10.7150/thno.21074
Abstract: The conventional chemotherapeutics could not be traced in vivo and provide timely feedback on the clinical effectiveness of drugs. Methods: In this study, a tumor-penetrating peptide RGERPPR (RGE) modified, Gd-DTPA conjugated, and doxorubicin (DOX) loaded… read more here.
Keywords: rge; penetrating peptide; tumor penetrating; dox ... See more keywords