pH/Cathepsin B Hierarchical‐Responsive Nanoconjugates for Enhanced Tumor Penetration and Chemo‐Immunotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202003757
Abstract: An ideal cancer nanomedicine should precisely deliver therapeutics to its intracellular target within tumor cells. However, the multiple biological barriers seriously hinder their delivery efficiency, leading to unsatisfactory therapeutic outcome. Herein, pH/cathepsin B hierarchical‐responsive nanoconjugates… read more here.
Keywords: tumor; chemo immunotherapy; cathepsin hierarchical; responsive nanoconjugates ... See more keywords
Dual pH/ROS-Responsive Nanoplatform with Deep Tumor Penetration and Self-Amplified Drug Release for Enhancing Tumor Chemotherapeutic Efficacy.
Sign Up to like & getrecommendations! Published in 2020 at "Small"
DOI: 10.1002/smll.202002188
Abstract: Poor deep tumor penetration and incomplete intracellular drug release remain challenges for antitumor nanomedicine application in clinical settings. Herein, a nanomedicine (RLPA-NPs) is developed that can achieve prolonged blood circulation, deep tumor penetration, active-targeting of… read more here.
Keywords: tumor penetration; drug; deep tumor; rlpa nps ... See more keywords
Oral Nanomotor-Enabled Mucus Traverse and Tumor Penetration for Targeted Chemo-Sono-Immunotherapy against Colon Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202203466
Abstract: The therapeutic outcomes of oral nanomedicines against colon cancer are heavily compromised by their lack of specific penetration into the internal tumor, favorable anti-tumor activity, and activation of anti-tumor immunity. Herein, hydrogen peroxide (H2 O2… read more here.
Keywords: tumor penetration; colon cancer; tumor;
NIR powered Janus nanocarrier for deep tumor penetration
Sign Up to like & getrecommendations! Published in 2020 at "Applied Materials Today"
DOI: 10.1016/j.apmt.2019.100504
Abstract: Abstract To improve the utilization and achieve deep tumor penetration of nanocarriers, we developed a Janus nanocarrier by simply sputter Au on a mesoporous silica nanocarrier. Such Janus nanocarrier with an Au surface that could… read more here.
Keywords: janus nanocarrier; tumor penetration; nir powered; deep tumor ... See more keywords
Enzyme-triggered size shrink and laser-enhanced NO release nanoparticles for deep tumor penetration and combination therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.03.046
Abstract: Chemotherapy remains restricted by poor drug delivery efficacy due to the heterogenous nature of tumor. Herein, we presented a novel nanoparticle that could not only response to the tumor microenvironment but also modulate it for… read more here.
Keywords: tumor penetration; laser; penetration combination; penetration ... See more keywords
Programmed 'triple-mode' anti-tumor therapy: Improving peritoneal retention, tumor penetration and activatable drug release properties for effective inhibition of peritoneal carcinomatosis.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.03.051
Abstract: Peritoneal carcinomatosis (PC) is a fatal condition arising in the gastrointestinal tract. PC patients administered drugs locally in the tumor region, such as in intraperitoneal chemotherapy (IPCh), suffer from low drug retention time and tumor… read more here.
Keywords: tumor penetration; drug; retention; peritoneal carcinomatosis ... See more keywords
Ultrasmall platinum nanoparticles enable deep tumor penetration and synergistic therapeutic abilities through free radical species-assisted catalysis to combat cancer multidrug resistance
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2019.123138
Abstract: Abstract Despite the significant advancements in the development of a wide-variety of nanocarriers-based delivery systems for cancer therapy, several predominant issues remain unaddressed such as active combat of cancer multidrug resistance (MDR) and the limited… read more here.
Keywords: tumor penetration; penetration; free radical; deep tumor ... See more keywords
Engineered nanomedicines with enhanced tumor penetration
Sign Up to like & getrecommendations! Published in 2019 at "Nano Today"
DOI: 10.1016/j.nantod.2019.100800
Abstract: Abstract Nanomedicine has been extensively explored to enhance the efficacy of chemotherapy with modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is inefficient tumor penetration caused by specific tumor microenvironments,… read more here.
Keywords: tumor penetration; nanomedicines enhanced; engineered nanomedicines; enhanced tumor ... See more keywords
Enhancing Tumor Penetration of Nanomedicines.
Sign Up to like & getrecommendations! Published in 2017 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.7b00068
Abstract: Tumor-targeted nanomedicines have been extensively applied to alter the drawbacks and enhance the efficacy of chemotherapeutics. Despite the large number of preclinical nanomedicine studies showing initial success, their therapeutic benefit in the clinic has been… read more here.
Keywords: tumor penetration; penetration; penetration nanomedicines; size ... See more keywords
Monensin Enhanced Generation of Extracellular Vesicles as Transfersomes for Promoting Tumor Penetration of Pyropheophorbide-a from Fusogenic Liposome.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.1c04962
Abstract: The current state of antitumor nanomedicines is severely restricted by poor penetration in solid tumors. It is indicated that extracellular vesicles (EVs) secreted by tumor cells can mediate the intercellular transport of antitumor drug molecules… read more here.
Keywords: extracellular vesicles; penetration; generation; tumor penetration ... See more keywords
Enzyme-Triggered Size-Switchable Nanosystem for Deep Tumor Penetration and Hydrogen Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c18184
Abstract: The poor penetration of nanocarriers within tumor dense extracellular matrices (ECM) greatly restricts the access of anticancer drugs to the deep tumor cells, resulting in low therapeutic efficacy. Moreover, the high toxicity of the traditional… read more here.
Keywords: therapy; tumor penetration; size; tumor ... See more keywords