Protein Expression in Metastatic Melanoma and the Link to Disease Presentation in a Range of Tumor Phenotypes
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DOI: 10.3390/cancers12030767
Abstract: Malignant melanoma is among the most aggressive skin cancers and it has among the highest metastatic potentials. Although surgery to remove the primary tumor is the gold standard treatment, once melanoma progresses and metastasizes to… read more here.
Keywords: melanoma; protein expression; metastatic melanoma; tumor phenotypes ... See more keywords
Hypothesis: Why Different Types of SDH Gene Variants Cause Divergent Tumor Phenotypes
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DOI: 10.3390/genes13061025
Abstract: Despite two decades of paraganglioma-pheochromocytoma research, the fundamental question of how the different succinate dehydrogenase (SDH)-related tumor phenotypes are initiated has remained unanswered. Here, we discuss two possible scenarios by which missense (hypomorphic alleles) or… read more here.
Keywords: succinate; tumor phenotypes; variants cause; gene variants ... See more keywords