Integrative pipeline for profiling DNA copy number and inferring tumor phylogeny
Sign Up to like & getrecommendations! Published in 2018 at "Bioinformatics"
DOI: 10.1093/bioinformatics/bty057
Abstract: Summary: Copy number variation is an important and abundant source of variation in the human genome, which has been associated with a number of diseases, especially cancer. Massively parallel next‐generation sequencing allows copy number profiling… read more here.
Keywords: number; copy number; tumor phylogeny;
PhISCS: a combinatorial approach for subperfect tumor phylogeny reconstruction via integrative use of single-cell and bulk sequencing data
Sign Up to like & getrecommendations! Published in 2019 at "Genome Research"
DOI: 10.1101/gr.234435.118
Abstract: Available computational methods for tumor phylogeny inference via single-cell sequencing (SCS) data typically aim to identify the most likely perfect phylogeny tree satisfying the infinite sites assumption (ISA). However, the limitations of SCS technologies including… read more here.
Keywords: tumor phylogeny; sequencing data; bulk sequencing; phylogeny ... See more keywords