Tumor promoting role of anti-tumor macrophages in tumor microenvironment.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2017.04.005
Abstract: Recent advances in tumor biology demand detailed analysis of the complex interaction of tumor cells with their adjacent microenvironment (tumor stroma) to understand the various mechanisms involved in tumor growth and metastasis. Mononuclear phagocytes or… read more here.
Keywords: microenvironment tumor; promoting role; anti tumor; role anti ... See more keywords
P13.17 CD95 gene silencing affects growth and invasiveness of glioma-initiating cells in a CD95L-independent manner
Sign Up to like & getrecommendations! Published in 2021 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noab180.124
Abstract: CD95 (Fas/APO-1) holds a dual role of potential relevance in tumor development. CD95-CD95 ligand (CD95L) signaling regulates apoptotic cell death in CD95-expressing cells, but non-apoptotic, tumor-promoting CD95-CD95L signaling has been likewise described. Therapeutic stimulation of… read more here.
Keywords: cd95 cd95l; tumor promoting; cd95l; gic ... See more keywords
Abstract 5065: Cancer derived Escherichia coli induces tumor-promoting inflammatory cytokine IL-6 in cancer associated fibroblasts (CAFs) in a NF-κB/BRD4 dependent manner
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-5065
Abstract: Introduction: Chronic inflammatory responses within the colonic environment are critical to colorectal cancer (CRC) tumor development. While the exact causes of CRC development are unknown, recent data suggest that dysbiosis in the colonic microbiome results… read more here.
Keywords: fibroblasts cafs; promoting inflammatory; cancer; cancer associated ... See more keywords
Abstract 2033: Bidirectional paracrine IL-33-TGF-beta signaling underlies a tumor-promoting stem cell niche
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-2033
Abstract: Malignant tumor progression and aggressive tumor recurrence after treatment are driven by subsets of cancer stem cells (CSCs), but targeting CSCs remains a major challenge due to their plasticity. CSCs in squamous cell carcinoma reside… read more here.
Keywords: tgf beta; tumor; tumor promoting; niche ... See more keywords
Abstract 2350: Role of ECM hyaluronic acid in the tumor-promoting functions of TIMP-1
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2350
Abstract: Non-small cell lung carcinoma (NSCLC) is responsible for the most significant number of lung cancer deaths with over 85% of lung cancers falling in this category. The dismal outcomes of this disease are augmented by… read more here.
Keywords: promoting functions; tumor promoting; role; hyaluronic acid ... See more keywords
Primary Tr1 cells from metastatic melanoma eliminate tumor-promoting macrophages through granzyme B- and perforin-dependent mechanisms
Sign Up to like & getrecommendations! Published in 2017 at "Tumor Biology"
DOI: 10.1177/1010428317697554
Abstract: In malignant melanoma, tumor-associated macrophages play multiple roles in promoting tumor growth, such as inducing the transformation of melanocytes under ultraviolet irradiation, increasing angiogenesis in melanomas, and suppressing antitumor immunity. Because granzyme B- and perforin-expressing… read more here.
Keywords: melanoma; granzyme perforin; tr1 cells; promoting macrophages ... See more keywords
Blocking ERK1/2 signaling impairs TGF-β1 tumor promoting function but enhances its tumor suppressing role in intrahepatic cholangiocarcinoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Cell International"
DOI: 10.1186/s12935-017-0454-2
Abstract: BackgroundTransforming growth factor-β (TGF-β) plays a paradoxical role in cancer: it suppresses proliferation at early stages but promotes metastasis at late stages. This cytokine is upregulated in cholangiocarcinoma and is implicated in cholangiocarcinoma invasion and… read more here.
Keywords: tgf tumor; invasion; erk1; role ... See more keywords
Serum miRNAs associated with tumor-promoting cytokines in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0241593
Abstract: Tumor-promoting cytokines are a cause of tumor progression; therefore, identifying key regulatory microRNAs (miRNAs) for controlling their production is important. The aim of this study is to identify promising miRNAs associated with tumor-promoting cytokines in… read more here.
Keywords: mir 20a; promoting cytokines; mir; serum ... See more keywords
Exploring the tumor promoting role of anti-tumor macrophage: a developmental perspective
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Botany"
DOI: 10.21037/aob.2020.02.03
Abstract: Tumor-associated macrophages (TAMs), in close proximity or within tumor masses, are a type of cell belonging to the macrophage lineage that constantly shift their functional states in response to changes in the tumor microenvironment (TME).… read more here.
Keywords: exploring tumor; promoting role; role anti; macrophage ... See more keywords
Heterogeneous Nuclear Ribonucleoprotein A1 Loads Batched Tumor-Promoting MicroRNAs Into Small Extracellular Vesicles With the Assist of Caveolin-1 in A549 Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.687912
Abstract: MicroRNAs in small extracellular vesicle (sEV-miRNAs) have been widely investigated as crucial regulated molecules secreted by tumor cells to communicate with surroundings. It is of great significance to explore the loading mechanism of sEV-miRNAs by… read more here.
Keywords: batched tumor; sev mirnas; tumor promoting; micrornas small ... See more keywords
The Role of Atypical Chemokine Receptor D6 (ACKR2) in Physiological and Pathological Conditions; Friend, Foe, or Both?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.861931
Abstract: Chemokines exert crucial roles in inducing immune responses through ligation to their canonical receptors. Besides these receptors, there are other atypical chemokine receptors (ACKR1–4) that can bind to a wide range of chemokines and carry… read more here.
Keywords: role atypical; atypical chemokine; tumor; tumor promoting ... See more keywords