Soft matrices downregulate FAK activity to promote growth of tumor-repopulating cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.12.122
Abstract: Tumor-repopulating cells (TRCs) are a tumorigenic sub-population of cancer cells that drives tumorigenesis. We have recently reported that soft fibrin matrices maintain TRC growth by promoting histone 3 lysine 9 (H3K9) demethylation and Sox2 expression… read more here.
Keywords: tumor repopulating; repopulating cells; fibrin matrices; h3k9 methylation ... See more keywords
Tumor-Repopulating Cells Induce PD-1 Expression in CD8+ T Cells by Transferring Kynurenine and AhR Activation.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.02.005
Abstract: Despite the clinical successes fostered by immune checkpoint inhibitors, mechanisms underlying PD-1 upregulation in tumor-infiltrating T cells remain an enigma. Here, we show that tumor-repopulating cells (TRCs) drive PD-1 upregulation in CD8+ T cells through a transcellular… read more here.
Keywords: kynurenine; tumor repopulating; repopulating cells; cd8 cells ... See more keywords
Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma
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DOI: 10.1038/onc.2016.520
Abstract: For cancer cells to proliferate, a balance must be built between biomass-forming, glucose-metabolized intermediates and ATP production. How intrinsic glucose carbon flow regulates this balance remains unclear. Here we show that mitochondrial phosphoenolpyruvate carboxykinase (PCK2),… read more here.
Keywords: tumor repopulating; carbon; pck2; tricarboxylic acid ... See more keywords
Cell Softness Prevents Cytolytic T-cell Killing of Tumor-Repopulating Cells
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DOI: 10.1158/0008-5472.can-20-2569
Abstract: Tumor-repopulating cells evade CD8+ cytolytic T-cell killing through a mechanical softness mechanism, underlying the impediment of perforin pore formation at the immune synapse site. Biomechanics is a fundamental feature of a cell. However, the manner… read more here.
Keywords: tumor repopulating; softness; tumor; cell ... See more keywords