A graph-based algorithm for estimating clonal haplotypes of tumor sample from sequencing data
Sign Up to like & getrecommendations! Published in 2018 at "BMC Medical Genomics"
DOI: 10.1186/s12920-018-0457-4
Abstract: AbstractBackgroundHaplotype phasing is an important step in many bioinformatics workflows. In cancer genomics, it is suggested that reconstructing the clonal haplotypes of a tumor sample could facilitate a comprehensive understanding of its clonal architecture and… read more here.
Keywords: clonal haplotypes; tumor sample; sequencing data; graph based ... See more keywords
Joint Lp-Norm and L2,1-Norm Constrained Graph Laplacian PCA for Robust Tumor Sample Clustering and Gene Network Module Discovery
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.621317
Abstract: The dimensionality reduction method accompanied by different norm constraints plays an important role in mining useful information from large-scale gene expression data. In this article, a novel method named Lp-norm and L2,1-norm constrained graph Laplacian… read more here.
Keywords: tumor sample; sample clustering; norm; graph laplacian ... See more keywords