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Published in 2019 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.8b00539
Abstract: We report the design, synthesis, and evaluation of novel 5-fluorouracil (5FU) prodrugs 1a,1b that are efficiently activated by the high level of reactive oxygen species (ROS) in cancer cells. Prodrugs 1a,1b selectively kill cancer cells…
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Keywords:
reactive oxygen;
oxygen species;
selectivity fluorouracil;
tumor selectivity ... See more keywords
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Published in 2017 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-17-0051
Abstract: T cell–based immunotherapy against melanoma-associated antigens can result in on-target/off-tumor cytotoxicity. SLC45A2, a protein overexpressed in melanoma compared with normal melanocytes, was identified as a T-cell target that may be less prone to inducing autoimmune…
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Keywords:
melanoma;
slc45a2;
tumor selectivity;
selectivity reduced ... See more keywords