Somatic tumor testing implications for Lynch syndrome germline genetic testing.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2022.02.010
Abstract: Clinicians involved in cancer treatment often utilize somatic tumor sequencing to help tailor chemotherapy and immunotherapy. However, somatic tumor sequencing can also identify patients at risk for germline pathogenic variants causing cancer predisposition syndromes like… read more here.
Keywords: tumor; tumor testing; lynch syndrome; tumor sequencing ... See more keywords
Currently favored sampling practices for tumor sequencing can produce optimal results in the clinical setting
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-71382-3
Abstract: Tumor heterogeneity is a consequence of clonal evolution, resulting in a fractal-like architecture with spatially separated main clones, sub-clones and single-cells. As sequencing an entire tumor is not feasible, we ask the question whether there… read more here.
Keywords: tumor; practices tumor; sampling practices; currently favored ... See more keywords
Strategy for Identification of an Inherited Leukemia Predisposition in a 299 Patients Cohort with Tumor-Only Sequencing Data
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-126634
Abstract: Myeloid neoplasms (MN) are usually sporadic late-onset cancers; nevertheless, growing evidence suggests that ~5% of the cases could emerge as a consequence of inherited predisposition. Indeed, the 2016 revision of the World Health Organization (WHO)… read more here.
Keywords: sequencing data; predisposition; nature; tumor sequencing ... See more keywords