Fused Cytomembrane-Camouflaged Nanoparticles for Tumor-Specific Immunotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300323
Abstract: Tumor immunotherapy is commonly hindered by inefficient delivery and presentation of tumor antigens as well as immunosuppressive tumor microenvironment. To overcome these barriers, we report a tumor-specific nanovaccine capable of delivering tumor antigens and adjuvants to… read more here.
Keywords: tumor specific; immunotherapy; fused cytomembrane; tumor ... See more keywords
Tumor-Specific Peroxynitrite Overproduction Disrupts Metabolic Homeostasis for Sensitizing Melanoma Immunotherapy.
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DOI: 10.1002/adma.202301455
Abstract: Tumor cells elicit metabolic reprogramming to establish an immunosuppressive tumor microenvironment (TME) for escaping from immunosurveillance. Therefore, interrupting the metabolic adaption of tumor cells might be a promising strategy for TME immunomodulation, favoring immunotherapy. Herein,… read more here.
Keywords: tumor specific; overproduction; melanoma; tumor ... See more keywords
Covalent Organic Framework Nanobowls as Activatable Nanosensitizers for Tumor‐Specific and Ferroptosis‐Augmented Sonodynamic Therapy
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DOI: 10.1002/advs.202206009
Abstract: Covalent organic frameworks (COFs) have attracted increasing attention for biomedical applications. COFs‐based nanosensitizers with uniform nanoscale morphology and tumor‐specific curative effects are in high demand; however, their synthesis is yet challenging. In this study, distinct… read more here.
Keywords: tumor specific; therapy; activatable nanosensitizers; covalent organic ... See more keywords
Tumor‐Specific Transcripts Are Frequently Expressed in Hepatocellular Carcinoma With Clinical Implication and Potential Function
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30805
Abstract: Hepatocellular carcinoma (HCC) is a highly lethal cancer and its underlying etiology remains understudied. The immense diversity and complexity of the cancer transcriptome hold the potential to yield tumor‐specific transcripts (TSTs). Here, we showed that… read more here.
Keywords: hepatocellular carcinoma; frequently expressed; hcc; tumor specific ... See more keywords
CTLA‐4 inhibition facilitates follicular T and B cell interaction and the production of tumor‐specific antibodies
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Cancer"
DOI: 10.1002/ijc.34438
Abstract: Immune checkpoint inhibitors (ICIs) induce activation and expansion of cytotoxic T cells. To depict a comprehensive immune cell landscape reshaped by the CTLA‐4 checkpoint inhibitor, we performed single‐cell RNA sequencing in a mouse syngeneic tumor… read more here.
Keywords: tumor specific; cell; inhibition facilitates; tumor ... See more keywords
Color-Convertible, Unimolecular, Micelle-Based, Activatable Fluorescent Probe for Tumor-Specific Detection and Imaging In Vitro and In Vivo.
Sign Up to like & getrecommendations! Published in 2017 at "Small"
DOI: 10.1002/smll.201604062
Abstract: Recent years have witnessed significant progress in molecular probes for cancer diagnosis. However, the conventional molecular probes are designed to be "always-on" by attachment of tumor-targeting ligands, which limits their abilities to diagnose tumors universally… read more here.
Keywords: unimolecular micelle; vivo; tumor specific; color convertible ... See more keywords
Enhanced Chemodynamic Therapy Mediated by a Tumor-Specific Catalyst in Synergy with Mitophagy Inhibition Improves the Efficacy for Endometrial Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202301497
Abstract: Chemodynamic therapy (CDT) relies on the tumor microenvironment (e.g., high H2 O2 level) responsive Fenton-like reactions to produce hydroxyl radicals (·OH) against tumors. However, endogenous H2 O2 is insufficient for effective chemodynamic responses. An NAD(P)H:… read more here.
Keywords: endometrial cancer; tumor specific; inhibition; therapy ... See more keywords
Tumor-Specific CD8+ T-Cell Responses Induced by DNA Vaccination.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0872-2_12
Abstract: DNA vaccines assisted by electroporation efficiently trigger antitumor cytotoxic CD8+ T cell responses in preclinical cancer models and hold potential for human use. They can be easily engineered to express either tumor-associated self-antigens, which are… read more here.
Keywords: cd8 cell; cell responses; tumor specific; tumor ... See more keywords
The Pituitary Tumors and Their Tumor-Specific Microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-59038-3_7
Abstract: Pituitary tumors develop within a macroenvironment and microenvironment that favor their overall survival. Given the pituitary gland's unique anatomic, histological, and physiological properties, the role of the TME in the pituitary tumors is central. This… read more here.
Keywords: microenvironment; tumors tumor; specific microenvironment; tumor specific ... See more keywords
The effects of targeted immune-regulatory strategies on tumor-specific T-cell responses in vitro
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02760-z
Abstract: Immune-related adverse events (IrAEs) are auto-immune reactions associated with immune checkpoint inhibitor-based therapy (ICI). Steroids are currently the first-line option for irAE management; however, recent studies have raised concerns regarding their potential impairment of tumor-specific… read more here.
Keywords: targeted immune; specific cell; cell activation; tumor specific ... See more keywords
Intrinsic cancer vaccination.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2019.05.007
Abstract: Immunotherapy is revolutionizing the treatment of cancer, and the current immunotherapeutics have remarkably improved the outcomes for some cancer patients. However, we still need answers for patients with immunologically cold tumors that do not benefit… read more here.
Keywords: intrinsic cancer; tumor specific; cancer; cell ... See more keywords